Polymorphisms affecting vitamin D-binding protein modify the relationship between serum vitamin D (25[OH]D3) and food allergy.
J Allergy Clin Immunol. 2015 Aug 7. pii: S0091-6749(15)00911-2. doi: 10.1016/j.jaci.2015.05.051. [Epub ahead of print]
Koplin JJ1, Suaini NH2, Vuillermin P3, Ellis JA2, Panjari M4, Ponsonby AL2, Peters RL2, Matheson MC1, Martino D2, Dang T4, Osborne NJ5, Martin P4, Lowe A1, Gurrin LC1, Tang ML6, Wake M7, Dwyer T4, Hopper J8, Dharmage SC1, Allen KJ9; HealthNuts Study.
There is evolving evidence that vitamin D insufficiency may contribute to food allergy, but findings vary between populations. Lower vitamin D-binding protein (DBP) levels increase the biological availability of serum vitamin D. Genetic polymorphisms explain almost 80% of the variation in binding protein levels.
We sought to investigate whether polymorphisms that lower the DBP could compensate for adverse effects of low serum vitamin D on food allergy risk.
From a population-based cohort study (n = 5276) we investigated the association between serum 25-hydroxyvitamin D3 (25OHD3) levels and food allergy at age 1 year (338 challenge-proven food-allergic and 269 control participants) and age 2 years (55 participants with persistent and 50 participants with resolved food allergy). 25(OH)D3 levels were measured using liquid chromatography-tandem mass spectrometry and adjusted for season of blood draw. Analyses were stratified by genotype at rs7041 as a proxy marker of DBP levels (low, the GT/TT genotype; high, the GG genotype).
Low serum 25(OH)D3 level (≤50 nM/L) at age 1 years was associated with food allergy, particularly among infants with the GG genotype (odds ratio [OR], 6.0; 95% CI, 0.9-38.9) but not in those with GT/TT genotypes (OR, 0.7; 95% CI, 0.2-2.0; P interaction = .014). Maternal antenatal vitamin D supplementation was associated with less food allergy, particularly in infants with the GT/TT genotype (OR, 0.10; 95% CI, 0.03-0.41).
Persistent vitamin D insufficiency increased the likelihood of persistent food allergy (OR, 12.6; 95% CI, 1.5-106.6), particularly in those with the GG genotype.
Polymorphisms associated with lower DBP level attenuated the association between low serum 25(OH)D3 level and food allergy, consistent with greater vitamin D bioavailability in those with a lower DBP level. This increases the biological plausibility of a role for vitamin D in the development of food allergy.
- Immune modulation by Vitamin D, food allergy, chart of genes – July 2015
- Food allergy and low vitamin D – unsure – June 2013 might the problem be due to DBP?
- Allergy - Overview
- Huge increase in food allergies in Australia may be due to low vitamin D
Pages listed in BOTH the categories Autoimmune and Vitamin D Binding Protein
The items in Autoimmune and Infant-Child D are listed here:
- Kawasaki disease (strawberry tongue) not treated by occasional 400 IU of Vitamin D – Feb 2019
- Food allergy is linked to season of birth, sun exposure, and vitamin D deficiency – Jan 2019
- Childhood Food Allergies (UK 1 in 14) – huge recent increase (low vitamin D) - Dec 2018
- Food allergies are associated with Vitamin D thru genes, etc. – March 2018
- Food allergies in children may be due to earlier low Vitamin D, Omega-3 and Zinc – Aug 2017
- T1 Diabetes associated with many other autoimmune diseases (all related to low vitamin D) – May 2017
- Infant allergy to cow’s milk will go away if have high levels of vitamin D – Jan 2017
- Food allergies and low vitamin D – thymus may be the connection – June 2016
- Food allergies 6 times higher in South Australia - 2009
- Hypothesis – Australia has highest rate of food allergy due to avoiding the sun – Sept 2015
- Food allergy 12X more likely if low vitamin D and vitamin D binding gene problem – Aug 2015
- Too much vitamin D: 1 pcnt increase in infants with food allergy, too little: 500 pcnt increase in children with food allergy - Aug 2015
- Kawasaki disease (strawberry tongue) associated with very low vitamin D – May 2015
- Less sun (less vitamin D) more anaphylaxis (severe allergic reaction) – June 2014
- Low vitamin D at birth associated with later milk sensitization, allergic rhinitis and asthma – Nov 2014
- Pink eye (seasonal allergic conjunctivitis) associated with low vitamin D and high vitamin E – March 2014
- 11X more non-immigrant children allergic to peanuts if vitamin D less than 20 ng – Feb 2013
- 30 to 40 ng of vitamin D associated with the least peanut allergy – Nov 2012
- High level of maternal vitamin D and infant food allergy – controversy
- Youths with autoimmunity disorders were 2.3 X more likely to be vitamin D deficient – July 2012
- Still unsure of association between vitamin D and asthma and allergies – review April 2012
- Allergy - Overview
- 3X more allergy to peanuts if child born with low UV – Feb 2011
- More childhood allergies when vitamin D is less than 15 ng – Feb 2011