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Chronic Kidney Disease decreases Vitamin D in 4 ways – Nov 2017

Role of Vitamin D in Uremic Vascular Calcification

BioMed Research International https://doi.org/10.1155/2017/2803579
Yi-Chou Hou ,1 Wen-Chih Liu ,2,3 Cai-Mei Zheng ,2,4,5 Jing-Quan Zheng,2,6 Tzung-Hai Yen ,7 and Kuo-Cheng Lu 1,2,8


Kidney problems are one of several health problems which result in less Vitamin D

Kidney category starts with

Overview Kidney and vitamin D contains the following summary

 Download the PDF from VitaminDWiki

The risk of cardiovascular death is 10 times higher in patients with CKD (chronic kidney disease) than in those without CKD. Vascular calcification, common in patients with CKD, is a predictor of cardiovascular mortality. Vitamin D deficiency, another complication of CKD, is associated with vascular calcification in patients with CKD. GFR decline, proteinuria, tubulointerstitial injury, and the therapeutic dose of active form vitamin D aggravate vitamin D deficiency and reduce its pleiotropic effect on the cardiovascular system. Vitamin D supplement for CKD patients provides a protective role in vascular calcification on the endothelium by

  • (1) renin-angiotensin-aldosterone system inactivation,
  • (2) alleviating insulin resistance,
  • (3) reduction of cholesterol and inhibition of foam cell and cholesterol efflux in macrophages, and
  • (4) modulating vascular regeneration.

For the arterial calcification, vitamin D supplement provides adjunctive role in regressing proteinuria, reverse renal osteodystrophy, and restoring calcification inhibitors. Recently, adventitial progenitor cell has been linked to be involved in the vascular calcification. Vitamin D may provide a role in modulating adventitial progenitor cells. In summary, vitamin D supplement may provide an ancillary role for ameliorating uremic vascular calcification.

Created by admin. Last Modification: Thursday January 7, 2021 16:29:30 GMT-0000 by admin. (Version 4)

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14822 4 ways CKD decreeases Vitamin D.jpg admin 07 Jan, 2021 133.55 Kb 346
14821 Role of Vitamin D in Uremic Vascular Calcification 2017.pdf admin 07 Jan, 2021 1.43 Mb 350