Vitamin D deficiency in chronic kidney disease: myth or reality?
Clin Chim Acta. 2021 Sep 1;S0009-8981(21)00310-7. doi: 10.1016/j.cca.2021.08.032
Priyadarshini G 1, Sreejith Parameswaran 2, Jayaprakash Sahoo 3, Sandhiya Selvarajan 4, Medha Rajappa 5
Kidney category starts with
Kidney category listing hassee also Overview Kidney and vitamin D
Peritoneal dialysis in titles in VitaminDWiki (21 titles as of Oct 2021)
Search VitaminDWiki for kidney transplant 798 items as of June 2019
CKD or CHRONIC KIDNEY DISEASE in title of 60 pages as of April 2022
Kidney Intervention trials using Vitamin D:
- 1,000 IU of vitamin D provides little benefit (Kidney transplant in this case) – April 2021
- Kidney patients who happened to be getting high-dose Calcitriol were 9X less likely to die of COVID-19 - April 6, 2021
- Chronic Kidney Disease (stage 3) slowed by 30 ng of Vitamin D and Calcitriol – Dec 2019
- Diabetic nephropathy (Kidney) treated by 50,000 IU of vitamin D weekly – RCT Jan 2019
- Hemodialysis patients (CKD) helped by weekly 50,000 IU of vitamin D – Jan 2017
- Kidney disease helped by active or high dose Vitamin D - Feb 2014
- Peritoneal Dialysis nicely treated by active vitamin D – July 2013
- 7100 IU (50000 weekly) restored vitamin D levels for those with Chronic Kidney Disease – July 2012
- Chronic Kidney Disease reduced with 3600 IU vitamin D (50000 twice a month)– RCT Aug 2012
- Overview Kidney and vitamin D
Overview Kidney and vitamin D contains the following summary
- FACT: The Kidneys are not the primary way to activate vitamin D, the tissues are
- FACT: When the Kidney has problems, there is less active vitamin D (Calcitriol) for the body
- FACT: When the Kidney has problems, there is increased death due to many factors - many of which are associated with lack of Calcitriol
- FACT: There are many on-going intervention clinical trials trying to determine how much of what kind of vitamin D is needed to treat the problem
- FACT: One Randomized Controlled Trial has proven that Vitamin D treats CKD
- FACT: 38% of seniors have Chronic Kidney Disease and most are unaware of it CDC statistics 2020
- FACT: Taking extra Vitamin D, in various forms, does not cause health problems - even if poor kidney
- Suggestion: Increase vitamin D getting into body now - and increase co-factors so that the vitamin D can be better used
Sun, UV lamp, Vitamin D supplement - probably > 5,000 IU,
Calcitriol - which bypasses the need for the kidney to activate vitamin D
Problems with Calcitriol however: typically only lasts for a few hours, also, possible complications
Update: Pre-cursor of active vitamin D made from plants is better than calcitriol – Sept 2012 - Category Kidney and Vitamin D contains
210 items Increased use of D has the following
People have been noticing, and increasing vitamin D (49 items) Studies are showing increased Vitamin D consumption and associated
Increased levels of vitamin D PLUS increased health- Vitamin D levels increased in Saudi Arabia over a decade (more sun or supplements) – Sept 2021
- 26 X increase in Vitamin D prescriptions for youths in England in 8 years – Dec 2019
- Vitamin D levels continue to rise in the US - April 2019
- 93 pcnt of these Lupus patients supplemented with Vitamin D - Nov 2020
- UK people with Multiple Sclerosis are 3X more likely to take Vitamin D - Oct 2020
- Parkinson patients: 60 pcnt taking Vitamin D – Dec 2019
- The use of Vitamin D to prevent prostate cancer doubled in a decade – May 2019
- Vitamin D levels continue to rise in the US - April 2019
- Vitamin D levels at Mayo Clinic increased over a decade – June 2018
- Parkinson’s patients – 41 percent now supplement with Vitamin D – Nov 2017
- Vitamin D levels in US: percent having more than 40 ng doubled (2001-2010) - Dec 2016
- Rickets almost eradicated in counties giving free Vitamin D, perhaps the world can learn – Dec 2019
- Vitamin D supplementation in Ireland - big increase in people with 20-50 nanograms in 20 years – June 2015
- Vitamin D in US children: those having more than 40 ng increased 60 percent (2001-2010) - Dec 2016
- 4 times fewer with vitamin D deficiency in just 4 years ( Connecticut) – March 2016
- 20X increase in vitamin D sold and 36 percent decrease in osteoporosis business in Australia – Nov 2013
- Many more people now have vitamin D levels above 50 ng, especially seniors – May 2015
- has the following chart for one US county
Background and objective: Chronic kidney disease (CKD) is a public health problem, which has a prevalence of 17.2% in India. As kidney function decreases, there is a gradual deterioration in the regulation of bone mineral homeostasis. Vitamin D is recognized as the central player in the maintenance of bonehealth in CKD. Kidney Disease Outcomes Quality Initiative (KDOQI) guidelines suggest that vitamin D supplementation should be given to all CKD patients with serum 25-hydroxyvitaminD (25(OH)D) level < 30 ng/mL. Hence we undertook this study to evaluate the vitamin D status in South Indian patients with CKD.Methods: Fifty-nine non-dialysis CKD patients of stage 3 and 4 were recruited and screened for 25(OH)D deficiency. Circulating levels of 25(OH)D were measured using chemiluminescence immunoassay. The estimated glomerular filtration rate (eGFR) was calculated using the Chronic Kidney Disease Epidemiology (CKD-EPI) equation. Serum calcium, phosphorous, creatinine and alkaline phosphatase levels were measured spectrophotometrically by an autoanalyzer.
Results: Contrary to published literature, 75% of South Indian CKD patients had normal 25(OH)D (≥30ng/mL), 15% of them had insufficient (20-29 ng/mL) and 10% had 25(OH)D deficiency (<20 ng/mL). Alkaline phosphatase levels were found to be increased in only 20% of cases. Calcium1 levels were normal in all CKD cases and hyperphosphatemia was observed in 5% of CKD patients.
Conclusion: We found that most of our CKD patients (75%) had normal vitamin D levels. This paradoxical finding could be explained by the fact that most of them gave a history of intake of vitamin D and calcium supplements, as advised by their doctors before coming to our institute. Hence we conclude that before prescribing vitamin D or calcium supplements to CKD patients, their 25(OH)D status should be ascertained to prevent hypervitaminosis D and its complications.
More people with Chronic Kidney Disease are now getting Vitamin D prescriptions (India) – Sept 2021Printer Friendly PDF this page! Follow this page for updates557 visitors, last modified 05 Sep, 2021,