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Peritoneal dialysis probably consumes a lot more vitamin D than haemodialysis

Peritoneal dialysis filters out Vitamin D from the blood - it needs to be replaced.

Peritoneal dialysis appears to lead to low Vitamin D, anemia, inflammation, etc. - Sept 2021

Low serum vitamin D concentration is correlated with anemia, microinflammation, and oxidative stress in patients with peritoneal dialysis
J Transl Med . 2021 Sep 27;19(1):411. doi: 10.1186/s12967-021-03077-w.
Chi Zhang 1 2, Junsheng Wang 1, Xiaohui Xie 1, Dong Sun 3 4

Background: Peritoneal dialysis (PD) is a form of dialysis to replace the function of kidney, that uses the peritoneum as a dialysis membrane to remove metabolites and water retained in the body. Vitamin D deficiency is prevalent in patients treated with PD. This research investigated the correlation between serum 25-hydroxyvitamin D 25(OH)D concentration and anemia, microinflammation, and oxidative stress in PD patients.

Methods: 62 PD patients and 56 healthy volunteers were recruited in this research. Serum concentrations of 25(OH)D and basic parameters of anemia were detected. The correlation between serum 25(OH)D concentration with anemia, oxidative stress, and microinflammatory state were analyzed.

Results: In the PD group, the concentration of 25(OH)D was lower than the healthy control (HC) group (p < 0.001). Hemoglobin, red blood cell count (RBC), and total iron binding capacity (TIBC) in the PD group was significantly lower (all p < 0.001), while high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumor necrosis factor α (TNF-α) concentrations were significantly higher, than the HC group (all p < 0.001). In the PD group, malondialdehyde (MDA) concentration was higher than in the HC group (p < 0.001), while superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were lower (both p < 0.001). Serum 25(OH)D exhibited positive correlation with hemoglobin (r = 0.4509, p = 0.0002), RBC (r = 0.3712, p = 0.0030), TIBC (r = 0.4700, p = 0.0001), SOD (r = 0.4992, p < 0.0001) and GSH-Px (r = 0.4312, p = 0.0005), and negative correlation with hs-CRP (r = - 0.4040, p = 0.0011), TNF-α (r = - 0.4721, p = 0.0001), IL-6 (r = - 0.5378, p < 0.0001) and MDA (r = - 0.3056, p = 0.0157).

Conclusion: In conclusion, reduced serum 25(OH)D concentrations in PD patients contribute to anemia, oxidative stress and microinflammatory state.
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Peritoneal dialysis and low Vitamin D - April 2014

Serum 25-hydroxy vitamin D concentrations are more deficient/insufficient in peritoneal dialysis than haemodialysis patients in a sunny climate
Journal of Human Nutrition and Dietetics DOI: 10.1111/jhn.12234
K. Hanna1,k.hanna@qut.edu.au, R. G. Fassett2,3, E. Gill2, H. Healy2, M. Kimlin1, L. Ross2 andS. Ash1
1Queensland University of Technology, Brisbane, QLD, Australia
2Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia
3The University of Queensland, Brisbane, QLD, Australia

Background: Research has identified associations between serum 25(OH)D and a range of clinical outcomes in chronic kidney disease and wider populations. The present study aimed to investigate vitamin D deficiency/insufficiency in dialysis patients and the relationship with vitamin D intake and sun exposure.

Methods: A cross-sectional study was used. Participants included 30 peritoneal dialysis (PD) (43.3% male; 56.87 ± 16.16 years) and 26 haemodialysis (HD) (80.8% male; 63.58 ± 15.09 years) patients attending a department of renal medicine. Explanatory variables were usual vitamin D intake from diet/supplements (IU day−1) and sun exposure (min day−1). Vitamin D intake, sun exposure and ethnic background were assessed by questionnaire. Weight, malnutrition status and routine biochemistry were also assessed. Data were collected during usual department visits. The main outcome measure was serum 25(OH)D (nm).

Results: Prevalence of inadequate/insufficient vitamin D intake differed between dialysis modality, with 31% and 43% found to be insufficient (<50 nm) and 4% and 33% found to be deficient (<25 nm) in HD and PD patients, respectively (P < 0.001). In HD patients, there was a correlation between diet and supplemental vitamin D intake and 25(OH)D (ρ = 0.84, P < 0.001) and average sun exposure and 25(OH)D (ρ = 0.50, P < 0.02). There were no associations in PD patients. The results remained significant for vitamin D intake after multiple regression, adjusting for age, gender and sun exposure.

Conclusions: The results highlight a strong association between vitamin D intake and 25(OH)D in HD but not PD patients, with implications for replacement recommendations. The findings indicate that, even in a sunny climate, many dialysis patients are vitamin D deficient, highlighting the need for exploration of determinants and consequences.

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See also VitaminDWiki

Overview Kidney and vitamin D contains the following summary

See also Web

  • Some hemodialysis machines decrease the vitamin D level by 17% compared to the other machines
    “Impact of the type of dialysis membranes on the circulating concentration of markers of vitamin D metabolism” is at
  • Dialysis Wikipedia
    Hemodialysis, Paediatric Dialysis, Peritoneal dialysis, Hemofiltration, Hemodiafiltration. Intestinal dialysis



Effects of vitamin D on parathyroid hormone and clinical outcomes in peritoneal dialysis: a narrative review.

J Nephrol. 2014 Jul 11.
Russo R1, Ruospo M, Cozzolino M, De Nicola L, Icardi A, Paoletti E, Mazzaferro S.
1Division of Nephrology, Dialysis and Transplantation, Azienda Ospedaliero Universitaria Consorziale, Policlinico di Bari, Piazza G. Cesare, 11, 70124, Bari, Italy, roberto.russo at policlinico.ba.it.

Vitamin D deficiency is very prevalent in dialysis and peritoneal dialysis (PD) patients show lower levels of cholecalciferol (25(OH)D3) than hemodialysis patients. We conducted a systematic narrative review to assess the effects of vitamin D therapy on control of secondary hyperparathyroidism and clinical outcomes induced by vitamin D pleiotropic effects. Medline database was searched for cohort and intervention studies reporting data on vitamin D (all sterols including synthetic analogs) and peritoneal dialysis without language restriction. Two authors independently extracted data. Twenty-nine observational and eleven interventional studies were identified for inclusion (1,036 subjects). PTH levels decreased in twenty-nine studies, increased in one study and remained stable in ten studies. Thirty-three studies analyzed the oral route for vitamin D administration, ten the intraperitoneal, one the subcutaneous and one the intravenous. A significant decrease of peritonitis risk was observed in two studies. Proteinuria decreased in four studies and remained stable in one study. Peritoneal protein loss decreased in one study and was stable in two studies. Studies on the therapeutic effects of vitamin D in PD are limited and describe small population samples. Moreover, vitamin D compounds do not consistently reduce PTH levels. The administration of active vitamin D in PD may have interesting pleiotropic effects such as decreasing proteinuria and peritoneal protein loss. According to these effects, vitamin D could help to preserve residual renal function and ensure efficient peritoneal membrane dialysance.

Peritoneal Dialysis associated with Global Cognitive Impairment (via low vitamin D) Dec 2015

Vitamin D Status Is an Independent Risk Factor for Global Cognitive Impairment in Peritoneal Dialysis Patients
PLoS One. 2015 Dec 2;10(12):e0143782. doi: 10.1371/journal.pone.0143782. eCollection 2015.
.Liu GL1, Pi HC2, Hao L1, Li DD1, Wu YG1, Dong J2.

OBJECTIVE: Vitamin D (VD) deficiency is an independent risk factor for cognitive impairment (CI) in the general population, but VD status in peritoneal dialysis (PD) patients has not been investigated. In this study, we aimed to investigate the relationship between serum VD levels and global and specific cognitive functions in PD patients.

DESIGN AND SETTING: Cross-sectional study, simultaneously conducted at two PD centers.

PATIENTS: Clinically stable patients (n = 273) undergoing PD for at least 3 months were enrolled over a period of one year.

MAIN OUTCOME MEASURES: Demographic and comorbidity data were recorded, and routine biochemical parameters and serum 25-hydroxyvitamin D (25(OH) D) levels of overnight fasted patients were determined. Global cognitive function was assessed by the Modified Mini-Mental State Examination (3MS) score; executive function, by the trail making tests (Trails A and B ); and immediate memory, delayed memory, and language ability by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) sub-tests.

RESULTS: In the univariate analysis, serum 25(OH) D levels significantly correlated with 3MS scores (r = -0.139; P = 0.02), and Trail A (r = -0.188; P = 0.002) and B (r = -0.154; P = 0.01) completion times. In the multivariate analysis, 25(OH) D was found to be independently associated with global CI, but not with executive dysfunction. Serum 25(OH) D could not predict scores of immediate/delayed memory and language ability.

CONCLUSIONS: VD deficiency is highly prevalent in PD patients and is an independent risk factor for global CI in this patient cohort.
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39+ VitaminDWiki pages with HEMODIALYSIS etc in title

This list is automatically updated

Items found: 39
Title Modified
Vitamin d levels were restored from hemodialysis by 70,000 IU weekly total in 4 weeks - Feb 2024 25 Feb, 2024
Hemodialysis and Vitamin D - many studies 20 Jan, 2023
Kidney Dialysis, low Vitamin D, low Magnesium - many studies 02 Nov, 2022
Poor cognition 2X more likely in Hemodialysis Patients if low Vitamin D – Sept 2022 20 Sep, 2022
Dialysis patients 23 percent more likely to live if had just 10 ng more Vitamin D – meta-analysis Feb 2018 29 Sep, 2021
Peritoneal dialysis probably consumes a lot more vitamin D than haemodialysis 29 Sep, 2021
Hemodialysis associated with very poor mRNA response (wonder if low vitamin D) – March 26, 2021 31 Mar, 2021
2.8X more likely to die of hemodialysis if low on vitamin D 26 Mar, 2021
Patients on Hemodialysis 3X more likely if die of heart failure if low Magnesium – meta-analysis Jan 2021 26 Mar, 2021
Vitamin D is needed during Dialysis – initially only 29 pcnt tested, extensive education raised it to 32 pcnt – May 2020 28 Feb, 2021
Kidney Dialysis often filters out Vitamin D, a problem for vegetarians and others- Feb 2021 14 Feb, 2021
Hemodialysis with low vitamin D increases risk of 2 health problems by 10 percent – Aug 2020 06 Aug, 2020
Hemodialysis deaths less likely if take vitamin D, especially if highest dose vitamin D – Nov 2018 10 Nov, 2018
Dialysis patients who added Vitamin D were 41 percent less likely to get infection – Meta-analysis July 2018 31 Jul, 2018
Vitamin D Receptor activators (such as paricalcitol) treat dialysis patients similarly – Aug 2017 27 Aug, 2017
Hemodialysis patients (CKD) helped by weekly 50,000 IU of vitamin D – Jan 2017 27 Jul, 2017
Kidney Dialysis clinics reluctant to add vitamin D treatment as they are not reimbursed – Oct 2012 27 Jul, 2017
Low vitamin D associated with hemodialysis problems – May 2010 13 Mar, 2017
Peritoneal dialysis probably consumes a lot more vitamin D than haemodialysis – April 2014 24 Jun, 2016
Hemodialysis low vitamin D status was normalized with 28500 IU avg daily – Jan 2012 10 Oct, 2015
Hemodialysis not helped by weekly vitamin D2 – RCT April 2015 08 Apr, 2015
Dialysis patients need real vitamin D – Editorial July 2013 08 Apr, 2015
Peritoneal Dialysis nicely treated by active vitamin D – July 2013 04 Feb, 2015
1700 IU of vitamin D not enough to help hemodialysis patients – March 2013 13 Jan, 2015
25,0000 IU vitamin D weekly only raised 60 percent on hemodialysis above 30 ng – Nov 2014 13 Jan, 2015
Application to FDA for use of active Vitamin D for hemodialysis patients – July 2011 18 Feb, 2014
Those Dialysis patients with low vitamin D were 75% more likely to die – July 2013 12 Dec, 2013
Vitamin D3 far better than D2 for hemodialysis – Oct 2012 24 Aug, 2013
Virtually all black dialysis patients with low albumin are vitamin D deficient in the winter – Mar 2010 23 Jul, 2013
Dialysis patients with less than 15 ng of vitamin D did not feel well – March 2011 23 Jul, 2013
Dialysis patients with low vitamin D were 2.7 X more likely to die of heart problems – Feb 2011 23 Jul, 2013
Vitamin D tester falsely said half of hemodialysis patients had less than 30 ng – Jan 2013 01 Jun, 2013
Telomeres longer for dialysis patients having higher levels of vitamin D – March 2012 11 May, 2013
5700 IU of vitamin D helped half with chronic kidney disease if not having dialysis – July 2012 01 Sep, 2012
Majority of blacks on dialysis were vitamin D deficient - March 2010 12 Nov, 2011
Dialysis patients with higher levels of vitamin D were better – May 2011 24 May, 2011
Wearable dialysis device being tested which also converts vitamin D - Mar 2011 04 Mar, 2011
Clinical measures identify vitamin D deficiency in dialysis – Feb 2010 19 Jul, 2010
1700 IU per day of vit D2 was not enough to help dialysis No value for &#039;modification_date_major&#039;

Attached files

ID Name Comment Uploaded Size Downloads
16318 peritoneal dialysis 2021_compressed.pdf admin 29 Sep, 2021 426.78 Kb 255
6828 Dialysis costs.jpg admin 24 Jun, 2016 18.19 Kb 1574
6827 Global Cognitive Impairment.pdf admin 24 Jun, 2016 279.51 Kb 697
3794 Hemodialysis-en.svg.png admin 11 Apr, 2014 82.70 Kb 1032
3793 Peritoneal_dialysis.gif admin 11 Apr, 2014 11.37 Kb 1309