Vitamin D Status and All-Cause Mortality in Patients With Chronic Kidney Disease: A Systematic Review and Dose-Response Meta-Analysis
J Clin Endocrinol Metab, July 2017, 102(7):2136—2145 doi: 10.1210/jc.2017-00105
- Standard oral vitamin D is not a good way to supplement if have Chronic Kidney Disease – March 2016
- Vitamin D for kidney disease – use native or active form – Jan 2016
- 2.4 times more likely to die if have Chronic Kidney Disease and low vitamin D - Sept 2016 has the following chart
Kidney category starts withKidney category listing has
see also Overview Kidney and vitamin D
Peritoneal dialysis in titles in VitaminDWiki (21 titles as of Oct 2021)
CKD or CHRONIC KIDNEY DISEASE in title of 60 pages as of April 2022
- Chronic Kidney Disease decreases Vitamin D in 4 ways – Nov 2017
- Half as much chronic kidney disease infection if supplement with Vitamin D – 2018
- 2.4 times more likely to die if have Chronic Kidney Disease and low vitamin D - Sept 2016
- 4X more Chronic Kidney disease patients are now using vitamin D – March 2014
- Poor kidneys rarely get enough or the right form of vitamin D – Feb 2019
Overview Kidney and vitamin D contains the following summary
- FACT: The Kidneys are not the primary way to activate vitamin D, the tissues are
- FACT: When the Kidney has problems, there is less active vitamin D (Calcitriol) for the body
- FACT: When the Kidney has problems, there is increased death due to many factors - many of which are associated with lack of Calcitriol
- FACT: There are many on-going intervention clinical trials trying to determine how much of what kind of vitamin D is needed to treat the problem
- FACT: One Randomized Controlled Trial has proven that Vitamin D treats CKD
- FACT: 38% of seniors have Chronic Kidney Disease and most are unaware of it CDC statistics 2020
- FACT: Taking extra Vitamin D, in various forms, does not cause health problems - even if poor kidney
- Suggestion: Increase vitamin D getting into body now - and increase co-factors so that the vitamin D can be better used
Sun, UV lamp, Vitamin D supplement - probably > 5,000 IU,
Calcitriol - which bypasses the need for the kidney to activate vitamin D
Problems with Calcitriol however: typically only lasts for a few hours, also, possible complications
Update: Pre-cursor of active vitamin D made from plants is better than calcitriol – Sept 2012
- Category Kidney and Vitamin D contains
Ahmad Jayedi,1 Sepideh Soltani,2 and Sakineh Shab-Bidar1
1Department of Community Nutrition, School of Nutritional Science and Dietetics, Tehran University of Medical Science, 141-6443931, Tehran, Iran; and 2Department of Nutrition, School of Public Health, Iran University of Medical Sciences, 1449614535, Tehran, Iran
Context: The prevalence of vitamin D deficiency is high in patients with chronic kidney disease (CKD). Less attention has been paid to measurement and correction of a serum level of 25-hydroxyvitamin D [25(OH)D] in these patients.
Objective: We examined the association between different levels of serum 25(OH)D and risk of allcause mortality in patients with CKD.
Data Sources: Systematic search was done using MEDLINE and EMBASE from inception to November 2016. Reference lists of all relevant articles and reviews also were searched.
Study Selection: Prospective or retrospective cohort studies that reported risk estimates of all-cause mortality for three or more categories of serum 25(OH)D in patients with CKD were selected. Studies that reported results as continuous also were included. Two independent investigators screened and selected the articles. Of 1281 identified studies, 13 prospective cohort studies, two retrospective cohort studies, and one nested case-control study with 17,053 patients and 7517 incident deaths were included.
Data Extraction: Two independent authors extracted data from included studies. Any discrepancies were resolved through consensus.
Data Synthesis: Reported risk estimates were combined using a random-effects model. Summary risk estimates of all-cause mortality were 1.63 [95% confidence interval (CI), 1.32 to 1.94] for severe deficiency (<10 ng/mL), 1.22 (95% CI, 1.09 to 1.35) for mild deficiency (10 to 20 ng/mL), and 1.12 (95% CI, 1.06 to 1.18) for insufficiency (20 to 30 ng/mL).
Results were more evident in dialysis- dependent patients.
A 10-ng/mL increment in serum 25(OH)D was associated with a 21% reduction in the risk of overall mortality (relative risk, 0.79; 95% CI, 0.70 to 0.87). Lower risk of all-cause mortality was observed at a serum 25(OH)D of ~25 to 30 ng/mL. Dialysis treatment was one of the sources of variation between studies.Chronic Kidney Disease mortality is 60 percent less likely if good vitamin D – meta-analysis July 2017
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