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Chronic Kidney Disease mortality is 60 percent less likely if good vitamin D – meta-analysis July 2017

Vitamin D Status and All-Cause Mortality in Patients With Chronic Kidney Disease: A Systematic Review and Dose-Response Meta-Analysis

J Clin Endocrinol Metab, July 2017, 102(7):2136—2145 doi: 10.1210/jc.2017-00105



Kidney category starts with

Kidney category listing has 192 items

see also Overview Kidney and vitamin D
Search VitaminDWiki for dialysis OR haemodialysis 1040 items as of Nov 2018
Search VitaminDWiki for kidney transplant 798 items as of June 2019
"Chronic Kidney Disease" OR CKD 874 items as of Jan 2018

Calcitriol category listing has 46 items along with related searches

Kidney Intervention trials using Vitamin D:

Overview Kidney and vitamin D contains the following summary

  • FACT: Kidney is the primary way to activate vitamin D
  • FACT: When the Kidney has problems, there is less active vitamin D (Calcitriol) for the body
  • FACT: When the Kidney has problems, there is increased death due to many factors - many of which are associated with lack of Calcitriol
  • FACT: There are many on-going intervention clinical trials trying to determine how much of what kind of vitamin D is needed to treat the problem
  • FACT: One Randomized Controlled Trial has proven that Vitamin D treats CKD
  • FACT: Taking extra Vitamin D, in various forms, does not cause health problems - even if poor kidney
  • Suggestion: Increase vitamin D getting into body now - and increase co-factors so that the vitamin D can be better used
      Sun, UV lamp, Vitamin D supplement - probably > 5,000 IU,
    Calcitriol - which bypasses the need for the kidney to activate vitamin D
      Problems with Calcitriol however: typically only lasts for a few hours, also, possible complications
        Update: Pre-cursor of active vitamin D made from plants is better than calcitriol – Sept 2012
  • Category Kidney and Vitamin D contains 192 items

 Download the PDF from VitaminDWiki

Ahmad Jayedi,1 Sepideh Soltani,2 and Sakineh Shab-Bidar1
1Department of Community Nutrition, School of Nutritional Science and Dietetics, Tehran University of Medical Science, 141-6443931, Tehran, Iran; and 2Department of Nutrition, School of Public Health, Iran University of Medical Sciences, 1449614535, Tehran, Iran

Context: The prevalence of vitamin D deficiency is high in patients with chronic kidney disease (CKD). Less attention has been paid to measurement and correction of a serum level of 25-hydroxyvitamin D [25(OH)D] in these patients.

Objective: We examined the association between different levels of serum 25(OH)D and risk of allcause mortality in patients with CKD.

Data Sources: Systematic search was done using MEDLINE and EMBASE from inception to November 2016. Reference lists of all relevant articles and reviews also were searched.

Study Selection: Prospective or retrospective cohort studies that reported risk estimates of all-cause mortality for three or more categories of serum 25(OH)D in patients with CKD were selected. Studies that reported results as continuous also were included. Two independent investigators screened and selected the articles. Of 1281 identified studies, 13 prospective cohort studies, two retrospective cohort studies, and one nested case-control study with 17,053 patients and 7517 incident deaths were included.

Data Extraction: Two independent authors extracted data from included studies. Any discrepancies were resolved through consensus.

Data Synthesis: Reported risk estimates were combined using a random-effects model. Summary risk estimates of all-cause mortality were 1.63 [95% confidence interval (CI), 1.32 to 1.94] for severe deficiency (<10 ng/mL), 1.22 (95% CI, 1.09 to 1.35) for mild deficiency (10 to 20 ng/mL), and 1.12 (95% CI, 1.06 to 1.18) for insufficiency (20 to 30 ng/mL).
Results were more evident in dialysis- dependent patients.

A 10-ng/mL increment in serum 25(OH)D was associated with a 21% reduction in the risk of overall mortality (relative risk, 0.79; 95% CI, 0.70 to 0.87). Lower risk of all-cause mortality was observed at a serum 25(OH)D of ~25 to 30 ng/mL. Dialysis treatment was one of the sources of variation between studies.

Created by admin. Last Modification: Sunday February 24, 2019 15:13:03 GMT-0000 by admin. (Version 6)

Attached files

ID Name Comment Uploaded Size Downloads
8196 CKD mortality.pdf PDF 2017 admin 18 Jul, 2017 18:11 472.62 Kb 276
8195 CKD Mortality.jpg admin 18 Jul, 2017 18:10 24.02 Kb 226
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