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1,000 IU of vitamin D provides little benefit (Kidney transplant in this case) – April 2021

Correcting Anemia and Native Vitamin D Supplementation in Kidney Transplant Recipients (CANDLE-KIT): a Multicenter, 2×2 Factorial, Open-label, Randomized Clinical Trial

Transpl Int . 2021 Apr 22. doi: 10.1111/tri.13885


Increased chance of benefit if they had done one or more of the following:
Used more vitamin D(say 4,000 IU)
Started dosing weeks before transplant (dialysis often filters out the vitamin D)
Started with a loading dose
Used a different form of Vitamin D (such as Calcitriol)
Used a source of vitamin D that does not require a healthy gut (topical, UVB, injection)
Also added supplements which reduce inflammation (such as Omega-3)

Kidney category starts with:

Overview Kidney and vitamin D contains the following summary

 Download the PDF from VitaminDWiki

Anemia and vitamin D deficiency are associated with allograft failure, and hence, are potential therapeutic targets among kidney transplant recipients (KTRs). We conducted a multicenter, two-by-two factorial, open-label, randomized clinical trial to examine the effects of anemia correction and vitamin D supplementation on 2-year change in eGFR among KTRs (CANDLE-KIT). We enrolled 153 patients with anemia and >1-year history of transplantation across 23 facilities in Japan, and randomly assigned them to either a high or low hemoglobin target (>12.5 vs. <10.5 g/dL) and to either cholecalciferol 1000 IU/day or control. This trial was terminated early based on the planned interim intention-to-treat analyses (α=0.034). Among 125 patients who completed the study, 2-year decline in eGFR was smaller in the high vs. low hemoglobin group (i.e., -1.6±4.5 vs. -4.0±6.9 mL/min/1.73 m2 ; P=0.021), but did not differ between the cholecalciferol and control groups. These findings were supported by the fully-adjusted mixed effects model evaluating the rate of eGFR decline among all 153 participants. There were no significant between-group differences in all-cause death or the renal composite outcome in either arm. In conclusion, aggressive anemia correction showed a potential to preserve allograft kidney function.

Created by admin. Last Modification: Monday September 13, 2021 20:48:35 GMT-0000 by admin. (Version 8)

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