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Chronic Kidney disease in 20 percent of seniors in Taiwan – April 2017

Association between Parathyroid Hormone, 25 (OH) Vitamin D, and Chronic Kidney Disease: A Population-Based Study.

Biomed Res Int. 2017;2017:7435657. doi: 10.1155/2017/7435657. Epub 2017 Mar 7.
Wang WH1, Chen LW2, Lee CC3, Sun CY3, Shyu YC4, Hsu HR3, Chien RN2, Wu IW3.

VitaminDWiki Summary

Seniors (age 58 ± 13) taking part in a national health survey
19.8 % had Chronic Kidney Disease

Comment by VitaminDWiki

It is truly amazing that there are still CKD studies measuring Calcidiol
They should be measuring Calcitriol the output of the kidney, not the output of the liver
Getting Vitamin D into your body has the following chart
http://vitamindwiki.com/tiki-index.php?page_id=5644
Other ways to increase Vitamin D levels in the cells include Omega-3 and UV

See also VitaminDWiki

Kidney category starts with

Kidney category listing has 180 items

see also Overview Kidney and vitamin D
Search VitaminDWiki for dialysis OR haemodialysis 1040 items as of Nov 2018
Search VitaminDWiki for kidney transplant 469 items as of Jan 2018
"Chronic Kidney Disease" OR CKD 874 items as of Jan 2018

Calcitriol category listing has 43 items along with related searches

Kidney Intervention trials using Vitamin D:

Overview Kidney and vitamin D contains the following summary

  • FACT: Kidney is the primary way to activate vitamin D
  • FACT: When the Kidney has problems, there is less active vitamin D (Calcitriol) for the body
  • FACT: When the Kidney has problems, there is increased death due to many factors - many of which are associated with lack of Calcitriol
  • FACT: There are many on-going intervention clinical trials trying to determine how much of what kind of vitamin D is needed to treat the problem
  • FACT: One Randomized Controlled Trial has proven that Vitamin D treats CKD
  • FACT: Taking extra Vitamin D, in various forms, does not cause health problems - even if poor kidney
  • Suggestion: Increase vitamin D getting into body now - and increase co-factors so that the vitamin D can be better used
      Sun, UV lamp, Vitamin D supplement - probably > 5,000 IU,
    Calcitriol - which bypasses the need for the kidney to activate vitamin D
      Problems with Calcitriol however: typically only lasts for a few hours, also, possible complications
        Update: Pre-cursor of active vitamin D made from plants is better than calcitriol – Sept 2012
  • Category Kidney and Vitamin D contains 180 items


 Download the PDF from VitaminDWiki

Severity (stages) of CKD for the 20% having CKD

Image

Identification of the accurate risk factor for CKD remains mandatory to combat the high prevalence of diseases. Growing evidence suggests the association of serum vitamin D with diverse health conditions. However, the relationship between vitamin D, intact parathyroid hormone (PTH), and calcium-phosphate metabolism and development of CKD remains controversial. We conduct this cross-sectional observational study to investigate the association between serum 25 (OH) vitamin D, intact PTH, and calcium and phosphate levels with eGFR and albuminuria, as a surrogate marker of CKD, in a community population. A total of 4080 participants were recruited. The mean age was 58.4 ± 13.3 years and 1480 (36.3%) were men. The mean eGFR was 94.1 ± 26.3 mL/min/1.73 m2.
The prevalence of CKD was 19.8%. Serum 25 (OH) vitamin D and log intact PTH levels were inversely correlated with eGFR but positively correlated with log albuminuria. Logistic regression analysis identified the log intact PTH as an independent factor associated with eGFR ≤ 60 mL/min/1.73 m2 and proteinuria. This association was consistent when serum intact PTH was analyzed as continuous as well as categorical variables (as hyperparathyroidism). The relationship remains significant using resampling subset analysis with comparable baseline characteristics and adjustment for 25 (OH) vitamin D, calcium, and phosphate levels. This finding warranted further research to clarify the causal relationship of PTH/25 (OH) vitamin D with the risk of CKD in the general population.

PMID: 28367447 PMCID: PMC5359435 DOI: 10.1155/2017/7435657

Attached files

ID Name Comment Uploaded Size Downloads
7951 CKD in Taiwan.jpg admin 30 Apr, 2017 15:53 86.38 Kb 305
7950 Vit D Pth CKD.pdf PDF 2017 admin 30 Apr, 2017 15:49 1.30 Mb 98
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