Cross-sectional evaluation of the relationship between vitamin D status and supplement use across levels of kidney function in adults.
BMJ Open. 2019 Feb 22;9(2):e022471. doi: 10.1136/bmjopen-2018-022471.
Moore LW1,2, Suki WN3, Lunsford KE1,4, Sabek OM1,4, Knight RJ1,4, Gaber AO1,4.
- Chronic Kidney Disease patients need more than 20 ng of Vitamin D – workshop conclusion Oct 2018
- Chronic kidney treatment by Vitamin D lacks consensus: type, how much – Sept 2018
- Diabetic nephropathy (Kidney) treated by 50,000 IU of vitamin D weekly – RCT Jan 2019
- Dialysis patients 23 percent more likely to live if had just 10 ng more Vitamin D – meta-analysis Feb 2018
- Chronic Kidney Disease mortality is 60 percent less likely if good vitamin D – meta-analysis July 2017
Items in both Kidney and Calcitriol categories in VitaminDWiki:
- Vitamin D for kidney disease – use native or active form – Jan 2016
- Kidney failure – still debating what form of vitamin D to use – April 2016
- Magnesium reduced calcitriol (active vitamin D) artery calcification in CKD by 50 percent – Oct 2015
- Not as much active vitamin D if poor kidney function and low vitamin D – March 2015
- Calcitriol (active Vitamin D) recommended after kidney transplant – March 2014
- Kidney disease helped by active or high dose Vitamin D - Feb 2014
- Chronic Kidney Disease study not aware of appropriate forms of vitamin D – March 2014
- Time-release form of active vitamin D granted a patent for chronic kidney disease – July 2014
- Omega 3 increased by 60 percent the ACTIVE vitamin D in the blood – Aug 2012
- Vitamin D3 vs serum D3 (Calcitriol, HyD) – Jan 2012
- Vitamin D3 becomes Calcidiol which becomes Calcitriol
- Overview Kidney and vitamin D
Kidney category starts with
Kidney category listing hassee also Overview Kidney and vitamin D
Search VitaminDWiki for dialysis OR haemodialysis 1040 items as of Nov 2018
Search VitaminDWiki for kidney transplant 798 items as of June 2019
"Chronic Kidney Disease" OR CKD 874 items as of Jan 2018
Kidney Intervention trials using Vitamin D:
- Diabetic nephropathy (Kidney) treated by 50,000 IU of vitamin D weekly – RCT Jan 2019
- Hemodialysis patients (CKD) helped by weekly 50,000 IU of vitamin D – Jan 2017
- Kidney disease helped by active or high dose Vitamin D - Feb 2014
- Peritoneal Dialysis nicely treated by active vitamin D – July 2013
- 7100 IU (50000 weekly) restored vitamin D levels for those with Chronic Kidney Disease – July 2012
- Chronic Kidney Disease reduced with 3600 IU vitamin D (50000 twice a month)– RCT Aug 2012
- Overview Kidney and vitamin D
Overview Kidney and vitamin D contains the following summary
- FACT: Kidney is the primary way to activate vitamin D
- FACT: When the Kidney has problems, there is less active vitamin D (Calcitriol) for the body
- FACT: When the Kidney has problems, there is increased death due to many factors - many of which are associated with lack of Calcitriol
- FACT: There are many on-going intervention clinical trials trying to determine how much of what kind of vitamin D is needed to treat the problem
- FACT: One Randomized Controlled Trial has proven that Vitamin D treats CKD
- FACT: Taking extra Vitamin D, in various forms, does not cause health problems - even if poor kidney
- Suggestion: Increase vitamin D getting into body now - and increase co-factors so that the vitamin D can be better used
Sun, UV lamp, Vitamin D supplement - probably > 5,000 IU,
Calcitriol - which bypasses the need for the kidney to activate vitamin D
Problems with Calcitriol however: typically only lasts for a few hours, also, possible complications
Update: Pre-cursor of active vitamin D made from plants is better than calcitriol – Sept 2012 - Category Kidney and Vitamin D contains
186 items
Getting Vitamin D into your body
Different forms are needed for different problenms
Download the PDF from VitaminDWiki
OBJECTIVES:
The objective of this study was to assess vitamin D status of US non-pregnant adults using a standardised assay across 15 mL/min/1.73 m2 increments of kidney function, report the use of dietary supplements containing vitamin D and assess relationships between vitamin D and markers of bone resorption.DESIGN: This study is a cross-sectional evaluation.
SETTING: The study is from the US National Health and Nutrition Evaluation Survey in 2001-2012.
PARTICIPANTS: The participants were non-institutionalised, non-pregnant adults, age ≥20 years.
PRIMARY AND SECONDARY OUTCOME MEASURES:
The primary outcome measure was serum 25OHD evaluated using liquid chromatography-tandem mass spectroscopy traceable to international reference standards. Secondary outcome measures were use of dietary supplements containing vitamin D and the serum intact parathyroid hormone and bone-specific alkaline phosphatase in a subset of participants.RESULTS:
The median 25OHD concentration in 27 543 US non-pregnant adults was 25.7 ng/mL (range, 2.2-150.0 ng/mL). Vitamin D supplements were used by 38.0%; mean (SE)=757 (43) international units/day. The range of 25OHD concentration across groups, stratified by kidney function, was 23.0-28.1 ng/mL. The lowest concentration of 25OHD observed was in people with higher kidney function (23.0 ng/mL for estimated glomerular filtration rate >105 mL/min/1.73 m2). Only 24% of people not taking a dietary supplement had a 25OHD concentration >30 ng/mL. Serum intact parathyroid hormone inversely correlated with 25OHD within all kidney function groups. Bone-specific alkaline phosphatase was also negatively associated with 25OHD concentration.CONCLUSIONS:
These data indicate that 25OHD concentrations and supplement use may be suboptimal in a significant proportion of the population, across all kidney function levels. The response of bone resorption markers further suggests that 25OHD levels could be improved. Together, these data support a re-evaluation of the 25OHD concentration associated with health in adults.Poor kidneys rarely get enough or the right form of vitamin D – Feb 2019
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