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Hemodialysis patients (CKD) helped by weekly 50,000 IU of vitamin D – Jan 2017

Effect of vitamin D supplementation on endothelial dysfunction in hemodialysis patients.

Hemodial Int. 2017 Jan;21(1):97-106. doi: 10.1111/hdi.12439. Epub 2016 Jun 29.

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VitaminDWiki pages with DIALYSIS in title (21 as of Sept 2022)

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Items found: 21
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Dialysis patients 23 percent more likely to live if had just 10 ng more Vitamin D – meta-analysis Feb 2018 29 Sep, 2021
Peritoneal dialysis probably consumes a lot more vitamin D than haemodialysis 29 Sep, 2021
Vitamin D is needed during Dialysis – initially only 29 pcnt tested, extensive education raised it to 32 pcnt – May 2020 28 Feb, 2021
Kidney Dialysis often filters out Vitamin D, a problem for vegetarians and others- Feb 2021 14 Feb, 2021
Dialysis patients who added Vitamin D were 41 percent less likely to get infection – Meta-analysis July 2018 31 Jul, 2018
Vitamin D Receptor activators (such as paricalcitol) treat dialysis patients similarly – Aug 2017 27 Aug, 2017
Kidney Dialysis clinics reluctant to add vitamin D treatment as they are not reimbursed – Oct 2012 27 Jul, 2017
Peritoneal dialysis probably consumes a lot more vitamin D than haemodialysis – April 2014 24 Jun, 2016
Dialysis patients need real vitamin D – Editorial July 2013 08 Apr, 2015
Peritoneal Dialysis nicely treated by active vitamin D – July 2013 04 Feb, 2015
Those Dialysis patients with low vitamin D were 75% more likely to die – July 2013 12 Dec, 2013
Virtually all black dialysis patients with low albumin are vitamin D deficient in the winter – Mar 2010 23 Jul, 2013
Dialysis patients with less than 15 ng of vitamin D did not feel well – March 2011 23 Jul, 2013
Dialysis patients with low vitamin D were 2.7 X more likely to die of heart problems – Feb 2011 23 Jul, 2013
Telomeres longer for dialysis patients having higher levels of vitamin D – March 2012 11 May, 2013
5700 IU of vitamin D helped half with chronic kidney disease if not having dialysis – July 2012 01 Sep, 2012
Majority of blacks on dialysis were vitamin D deficient - March 2010 12 Nov, 2011
Dialysis patients with higher levels of vitamin D were better – May 2011 24 May, 2011
Wearable dialysis device being tested which also converts vitamin D - Mar 2011 04 Mar, 2011
Clinical measures identify vitamin D deficiency in dialysis – Feb 2010 19 Jul, 2010
1700 IU per day of vit D2 was not enough to help dialysis No value for 'modification_date_major'

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Overview Kidney and vitamin D contains the following summary

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Karakas Y1, Sahin G2, Urfali FE3, Bal C4, Degirmenci NA3, Sirmagul B5.
1 Department of Medical Oncology, Cancer Institute, Hacettepe University, Ankara, Turkey.
2 Department of Nephrology, School of Medicine, Osmangazi University, Eskisehir, Turkey.
3 Department of Radiology, School of Medicine, Osmangazi University, Eskisehir, Turkey.
4 Department of Biostatistics, School of Medicine, Osmangazi University, Eskisehir, Turkey.
5 Department of Pharmacology, School of Medicine, Osmangazi University, Eskisehir, Turkey.

% Flow-mediated dilatation (% increase in arterial diameter)

Image black = after 50,000 IU weekly

INTRODUCTION:
Patients with chronic kidney disease (CKD) commonly experience 25-hydroxyvitamin D3 (25-OH-D3) deficiency, and these patients have a higher incidence of cardiovascular diseases (CVDs) due to endothelial dysfunction (ED). The aim of our study was to investigate the effect of 25-OH-D3 deficiency and its supplementation on ED in patients with CKD.

METHODS:
Twenty-nine uremic patients on dialysis and 20 healthy controls were evaluated for ED by high-resolution Doppler ultrasonography of the brachial artery. In addition, 25-OH-D3-deficient patients (25-OH-D3 < 30 nmol/L) with CKD and healthy controls were evaluated for ED before and after 8 weeks of oral vitamin D (cholecalciferol, 50,000 units) treatment. All subjects were evaluated for percent flow-mediated dilatation (%FMD), percent endothelium-independent nitroglycerin-induced vasodilatation (%NID), and bilateral carotid intima-media thickness (CIMT).

FINDINGS:
Patients on dialysis had lower %FMD and %NID 6.11 [2.27-12.74] and 10.96 [5.43-16.4], respectively, than controls 15.84 [8.19-22.49] and 21.74 [12.49-29.4], respectively (P < 0.05). Patients on dialysis had higher left and right CIMT (0.79 ± 0.15 and 0.78 ± 0.14, respectively) than controls (0.60 ± 0.09 and 0.59 ± 0.09, respectively; P < 0.05). In 25-OH-D3-deficient patients with CKD, after vitamin D treatment, %FMD was significantly increased in dialysis patients (10.25 7.8-12.8) compared to before supplementation (5.4 [2.77-6.15]; P < 0.001).

DISCUSSION:
These results indicated that dialysis patients had significantly lower blood 25-OH-D3 levels and higher CIMT than healthy subjects. In addition, vitamin D supplementation improved ED and increased %FMD in dialysis patients. Our findings suggest that vitamin D supplementation in dialysis patients might prevent CKD.


Created by admin. Last Modification: Tuesday September 20, 2022 13:06:17 GMT-0000 by admin. (Version 13)

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8223 FMD.jpg admin 27 Jul, 2017 16:18 6.12 Kb 1004
8222 hemodialysis weekly D.pdf PDF 2017 admin 27 Jul, 2017 16:17 140.25 Kb 698
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