Loading...
 
Translate Register Log In Login with facebookLogin and Register

Hemodialysis patients (CKD) helped by weekly 50,000 IU of vitamin D – Jan 2017

Effect of vitamin D supplementation on endothelial dysfunction in hemodialysis patients.

Hemodial Int. 2017 Jan;21(1):97-106. doi: 10.1111/hdi.12439. Epub 2016 Jun 29.

VitaminDWiki

Kidney category starts with

Kidney category listing has 180 items

see also Overview Kidney and vitamin D
Search VitaminDWiki for dialysis OR haemodialysis 1040 items as of Nov 2018
Search VitaminDWiki for kidney transplant 469 items as of Jan 2018
"Chronic Kidney Disease" OR CKD 874 items as of Jan 2018

Calcitriol category listing has 43 items along with related searches

Kidney Intervention trials using Vitamin D:

Overview Kidney and vitamin D contains the following summary

  • FACT: Kidney is the primary way to activate vitamin D
  • FACT: When the Kidney has problems, there is less active vitamin D (Calcitriol) for the body
  • FACT: When the Kidney has problems, there is increased death due to many factors - many of which are associated with lack of Calcitriol
  • FACT: There are many on-going intervention clinical trials trying to determine how much of what kind of vitamin D is needed to treat the problem
  • FACT: One Randomized Controlled Trial has proven that Vitamin D treats CKD
  • FACT: Taking extra Vitamin D, in various forms, does not cause health problems - even if poor kidney
  • Suggestion: Increase vitamin D getting into body now - and increase co-factors so that the vitamin D can be better used
      Sun, UV lamp, Vitamin D supplement - probably > 5,000 IU,
    Calcitriol - which bypasses the need for the kidney to activate vitamin D
      Problems with Calcitriol however: typically only lasts for a few hours, also, possible complications
        Update: Pre-cursor of active vitamin D made from plants is better than calcitriol – Sept 2012
  • Category Kidney and Vitamin D contains 180 items

 Download the PDF from VitaminDWiki

Karakas Y1, Sahin G2, Urfali FE3, Bal C4, Degirmenci NA3, Sirmagul B5.
1 Department of Medical Oncology, Cancer Institute, Hacettepe University, Ankara, Turkey.
2 Department of Nephrology, School of Medicine, Osmangazi University, Eskisehir, Turkey.
3 Department of Radiology, School of Medicine, Osmangazi University, Eskisehir, Turkey.
4 Department of Biostatistics, School of Medicine, Osmangazi University, Eskisehir, Turkey.
5 Department of Pharmacology, School of Medicine, Osmangazi University, Eskisehir, Turkey.

% Flow-mediated dilatation (% increase in arterial diameter)

Image black = after 50,000 IU weekly

INTRODUCTION:
Patients with chronic kidney disease (CKD) commonly experience 25-hydroxyvitamin D3 (25-OH-D3) deficiency, and these patients have a higher incidence of cardiovascular diseases (CVDs) due to endothelial dysfunction (ED). The aim of our study was to investigate the effect of 25-OH-D3 deficiency and its supplementation on ED in patients with CKD.

METHODS:
Twenty-nine uremic patients on dialysis and 20 healthy controls were evaluated for ED by high-resolution Doppler ultrasonography of the brachial artery. In addition, 25-OH-D3-deficient patients (25-OH-D3 < 30 nmol/L) with CKD and healthy controls were evaluated for ED before and after 8 weeks of oral vitamin D (cholecalciferol, 50,000 units) treatment. All subjects were evaluated for percent flow-mediated dilatation (%FMD), percent endothelium-independent nitroglycerin-induced vasodilatation (%NID), and bilateral carotid intima-media thickness (CIMT).

FINDINGS:
Patients on dialysis had lower %FMD and %NID 6.11 [2.27-12.74] and 10.96 [5.43-16.4], respectively, than controls 15.84 [8.19-22.49] and 21.74 [12.49-29.4], respectively (P < 0.05). Patients on dialysis had higher left and right CIMT (0.79 ± 0.15 and 0.78 ± 0.14, respectively) than controls (0.60 ± 0.09 and 0.59 ± 0.09, respectively; P < 0.05). In 25-OH-D3-deficient patients with CKD, after vitamin D treatment, %FMD was significantly increased in dialysis patients (10.25 7.8-12.8) compared to before supplementation (5.4 [2.77-6.15]; P < 0.001).

DISCUSSION:
These results indicated that dialysis patients had significantly lower blood 25-OH-D3 levels and higher CIMT than healthy subjects. In addition, vitamin D supplementation improved ED and increased %FMD in dialysis patients. Our findings suggest that vitamin D supplementation in dialysis patients might prevent CKD.

PMID: 27358162 DOI: 10.1111/hdi.12439

Created by admin. Last Modification: Tuesday July 31, 2018 13:00:04 GMT-0000 by admin. (Version 9)

Attached files

ID Name Comment Uploaded Size Downloads
8223 FMD.jpg admin 27 Jul, 2017 16:18 6.12 Kb 365
8222 hemodialysis weekly D.pdf PDF 2017 admin 27 Jul, 2017 16:17 140.25 Kb 150
See any problem with this page? Report it (FINALLY WORKS)