Toggle Health Problems and D

Poor kidneys rarely get enough or the right form of vitamin D – Feb 2019

Cross-sectional evaluation of the relationship between vitamin D status and supplement use across levels of kidney function in adults.

BMJ Open. 2019 Feb 22;9(2):e022471. doi: 10.1136/bmjopen-2018-022471.
Moore LW1,2, Suki WN3, Lunsford KE1,4, Sabek OM1,4, Knight RJ1,4, Gaber AO1,4.


Items in both Kidney and Calcitriol categories in VitaminDWiki:

Kidney category starts with

Kidney category listing has 208 items

see also Overview Kidney and vitamin D
Search VitaminDWiki for dialysis OR haemodialysis 878 items not in PDF as of Aug 2020
Search VitaminDWiki for kidney transplant 798 items as of June 2019
"Chronic Kidney Disease" OR CKD 874 items as of Jan 2018

Calcitriol category listing has 52 items along with related searches

Kidney Intervention trials using Vitamin D:

Overview Kidney and vitamin D contains the following summary

Getting Vitamin D into your body

Different forms are needed for different problenms

 Download the PDF from VitaminDWiki

The objective of this study was to assess vitamin D status of US non-pregnant adults using a standardised assay across 15 mL/min/1.73 m2 increments of kidney function, report the use of dietary supplements containing vitamin D and assess relationships between vitamin D and markers of bone resorption.

DESIGN: This study is a cross-sectional evaluation.

SETTING: The study is from the US National Health and Nutrition Evaluation Survey in 2001-2012.

PARTICIPANTS: The participants were non-institutionalised, non-pregnant adults, age ≥20 years.

The primary outcome measure was serum 25OHD evaluated using liquid chromatography-tandem mass spectroscopy traceable to international reference standards. Secondary outcome measures were use of dietary supplements containing vitamin D and the serum intact parathyroid hormone and bone-specific alkaline phosphatase in a subset of participants.

The median 25OHD concentration in 27 543 US non-pregnant adults was 25.7 ng/mL (range, 2.2-150.0 ng/mL). Vitamin D supplements were used by 38.0%; mean (SE)=757 (43) international units/day. The range of 25OHD concentration across groups, stratified by kidney function, was 23.0-28.1 ng/mL. The lowest concentration of 25OHD observed was in people with higher kidney function (23.0 ng/mL for estimated glomerular filtration rate >105 mL/min/1.73 m2). Only 24% of people not taking a dietary supplement had a 25OHD concentration >30 ng/mL. Serum intact parathyroid hormone inversely correlated with 25OHD within all kidney function groups. Bone-specific alkaline phosphatase was also negatively associated with 25OHD concentration.

These data indicate that 25OHD concentrations and supplement use may be suboptimal in a significant proportion of the population, across all kidney function levels. The response of bone resorption markers further suggests that 25OHD levels could be improved. Together, these data support a re-evaluation of the 25OHD concentration associated with health in adults.

Created by admin. Last Modification: Saturday February 13, 2021 13:00:52 GMT-0000 by admin. (Version 9)

Attached files

ID Name Comment Uploaded Size Downloads
11463 Kidney cross-section.pdf PDF 2019 admin 25 Feb, 2019 15:10 513.48 Kb 391
See any problem with this page? Report it (FINALLY WORKS)