Cross-sectional evaluation of the relationship between vitamin D status and supplement use across levels of kidney function in adults.
BMJ Open. 2019 Feb 22;9(2):e022471. doi: 10.1136/bmjopen-2018-022471.
Moore LW1,2, Suki WN3, Lunsford KE1,4, Sabek OM1,4, Knight RJ1,4, Gaber AO1,4.
- Chronic Kidney Disease patients need more than 20 ng of Vitamin D – workshop conclusion Oct 2018
- Chronic kidney treatment by Vitamin D lacks consensus: type, how much – Sept 2018
- Diabetic nephropathy (Kidney) treated by 50,000 IU of vitamin D weekly – RCT Jan 2019
- Dialysis patients 23 percent more likely to live if had just 10 ng more Vitamin D – meta-analysis Feb 2018
- Chronic Kidney Disease mortality is 60 percent less likely if good vitamin D – meta-analysis July 2017
- Standard oral vitamin D is not a good way to supplement if have Chronic Kidney Disease – March 2016
- Chronic Kidney Disease Patients need Vitamin K – Jan 2019
- Kidney problems reduces Vitamin K. which causes cardiovascular problems – Aug 2018
Items in both Kidney and Calcitriol categories in VitaminDWiki:
- Calcitriol (active Vitamin D) prevents and treats COVID (with Chronic Kidney Disease in this case) June 2022
- Fully-activated Vitamin D (Calcitriol) is produced inside and outside of the kidneys – July 2020
- Kidney patients who happened to be getting high-dose Calcitriol were 9X less likely to die of COVID-19 - April 6, 2021
- Chronic Kidney Disease (stage 3) slowed by 30 ng of Vitamin D and Calcitriol – Dec 2019
- Vitamin D for kidney disease – use native or active form – Jan 2016
- Kidney failure – still debating what form of vitamin D to use – April 2016
- Magnesium reduced calcitriol (active vitamin D) artery calcification in CKD by 50 percent – Oct 2015
- Not as much active vitamin D if poor kidney function and low vitamin D – March 2015
- Calcitriol (active Vitamin D) recommended after kidney transplant – March 2014
- Kidney disease helped by active or high dose Vitamin D - Feb 2014
- Chronic Kidney Disease study not aware of appropriate forms of vitamin D – March 2014
- Time-release form of active vitamin D granted a patent for chronic kidney disease – July 2014
- Omega 3 increases vitamin D in the blood – many studies
- Vitamin D3 vs serum D3 (Calcitriol, HyD) – Jan 2012
- Vitamin D3 becomes Calcidiol which becomes Calcitriol
- Overview Kidney and vitamin D
Kidney category starts withKidney category listing has
see also Overview Kidney and vitamin D
Peritoneal dialysis in titles in VitaminDWiki (21 titles as of Oct 2021)
CKD or CHRONIC KIDNEY DISEASE in title of 60 pages as of April 2022
- Chronic Kidney Disease decreases Vitamin D in 4 ways – Nov 2017
- Half as much chronic kidney disease infection if supplement with Vitamin D – 2018
- 2.4 times more likely to die if have Chronic Kidney Disease and low vitamin D - Sept 2016
- 4X more Chronic Kidney disease patients are now using vitamin D – March 2014
- Poor kidneys rarely get enough or the right form of vitamin D – Feb 2019
Overview Kidney and vitamin D contains the following summary
- FACT: The Kidneys are not the primary way to activate vitamin D, the tissues are
- FACT: When the Kidney has problems, there is less active vitamin D (Calcitriol) for the body
- FACT: When the Kidney has problems, there is increased death due to many factors - many of which are associated with lack of Calcitriol
- FACT: There are many on-going intervention clinical trials trying to determine how much of what kind of vitamin D is needed to treat the problem
- FACT: One Randomized Controlled Trial has proven that Vitamin D treats CKD
- FACT: 38% of seniors have Chronic Kidney Disease and most are unaware of it CDC statistics 2020
- FACT: Taking extra Vitamin D, in various forms, does not cause health problems - even if poor kidney
- Suggestion: Increase vitamin D getting into body now - and increase co-factors so that the vitamin D can be better used
Sun, UV lamp, Vitamin D supplement - probably > 5,000 IU,
Calcitriol - which bypasses the need for the kidney to activate vitamin D
Problems with Calcitriol however: typically only lasts for a few hours, also, possible complications
Update: Pre-cursor of active vitamin D made from plants is better than calcitriol – Sept 2012
- Category Kidney and Vitamin D contains
Different forms are needed for different problenms
The objective of this study was to assess vitamin D status of US non-pregnant adults using a standardised assay across 15 mL/min/1.73 m2 increments of kidney function, report the use of dietary supplements containing vitamin D and assess relationships between vitamin D and markers of bone resorption.
DESIGN: This study is a cross-sectional evaluation.
SETTING: The study is from the US National Health and Nutrition Evaluation Survey in 2001-2012.
PARTICIPANTS: The participants were non-institutionalised, non-pregnant adults, age ≥20 years.
PRIMARY AND SECONDARY OUTCOME MEASURES:
The primary outcome measure was serum 25OHD evaluated using liquid chromatography-tandem mass spectroscopy traceable to international reference standards. Secondary outcome measures were use of dietary supplements containing vitamin D and the serum intact parathyroid hormone and bone-specific alkaline phosphatase in a subset of participants.
The median 25OHD concentration in 27 543 US non-pregnant adults was 25.7 ng/mL (range, 2.2-150.0 ng/mL). Vitamin D supplements were used by 38.0%; mean (SE)=757 (43) international units/day. The range of 25OHD concentration across groups, stratified by kidney function, was 23.0-28.1 ng/mL. The lowest concentration of 25OHD observed was in people with higher kidney function (23.0 ng/mL for estimated glomerular filtration rate >105 mL/min/1.73 m2). Only 24% of people not taking a dietary supplement had a 25OHD concentration >30 ng/mL. Serum intact parathyroid hormone inversely correlated with 25OHD within all kidney function groups. Bone-specific alkaline phosphatase was also negatively associated with 25OHD concentration.
These data indicate that 25OHD concentrations and supplement use may be suboptimal in a significant proportion of the population, across all kidney function levels. The response of bone resorption markers further suggests that 25OHD levels could be improved. Together, these data support a re-evaluation of the 25OHD concentration associated with health in adults.Poor kidneys rarely get enough or the right form of vitamin D – Feb 2019
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