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Kidney Inflammation not reduced by 30 ng Vitamin D (many health problems need 50 ng) – Nov 2022

Effects of vitamin D on inflammatory state in patients with chronic kidney disease: a controversial issue

Ther Apher Dial . 2022 Nov 8. doi: 10.1111/1744-9987.13949
Liangbin Zhao 1 , Guoshuang Zhu 2 , Ling Wu 1 , Dengpiao Xie 1

Background: The anti-inflammatory effect of vitamin D in patients with chronic kidney disease (CKD) remains controversial. This study aimed to conduct a meta-analysis of randomized controlled trials to assess the anti-inflammatory effects of vitamin D in patients with CKD.

Methods: We searched Embase, Science Citation Index, Medline, Cochrane Central Register of Controlled Trials, and Clinical Trial Registries for randomized controlled trials that comparing vitamin D with control groups for inflammatory markers in patients with CKD. Subgroup analysis were performed based on treatment duration (short-term treatment, long-term treatment), type of patients (predialysis CKD, dialysis, kidney transplant), 25(OH)D levels (25(OH)D deficiency or normal 25(OH)D), methods of C-reactive protein (CRP) test (standard CRP test or high-sensitivity CRP (hs-CRP) test) RESULTS: 18 trials with 1834 patients were included in the present study. There was no significant differences between the vitamin D group and control group for CRP (WMD, -0.3mg/L; 95% CI, -0.81 to 0.22, p=0.26, I2 =62%), interleukin-6 (IL-6) (WMD, -1.07pg/mL; 95% CI, -2.44 to 0.30, p=0.12, I2 =52%), and tumor necrosis factor-α (TNF-α) (WMD, -0.00pg/mL; 95% CI, -0.36 to 0.35, p=0.99, I2 =0%) in patients with CKD. Subgroup analysis showed vitasmin D can improve hs-CRP, but not CRP. The rest of subgroups showed that no significant differences was observed between the vitamin D group and control group based on 25(OH)D levels, treatment duration, and predialysis CKD or dialysis patients.

Conclusion: This meta-analysis demonstrates that vitamin D supplementation does not have anti-inflammatory effects in CKD patients. Well-designed randomized controlled trials with large samples are required to confirm this conclusion. It is still needed to find an effective treatment for inflammatory state in CKD.

Vitamin D needed to TREAT Health problems 30 ng rickets, 150 ng MS

Vitamin D Treats
150 ng Multiple Sclerosis *
80 ng Cluster Headache *
Reduced office visits by 4X *
70 ngSleep *
60 ngBreast Cancer death reduced 60%
Preeclampsia RCT
50 ng COVID-19
Infections Review
Infection after surgery
40 ng Breast Cancer 65% lower risk
ACL recovery
30 ng Rickets

* Evolution of experiments with patients, often also need co-factors

VitaminDWiki - Overview Kidney and vitamin D contains

VitaminDWiki - Inflammation category contains

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Example studies


VitaminDWiki - 4 studies in both categories Kidney and Inflammation

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