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Inflammation of blood vessels (vasculitis): low Vitamin D and 22 X more likely to have kidney problems – March 2022


Vitamin D levels in patients with small and medium vessel vasculitis

Reumatol Clin (Engl Ed) . 2022 Mar;18(3):141-146. doi: 10.1016/j.reumae.2020.11.004 - behind paywall
Fatma Nur Korkmaz 1, Gulsen Ozen 2, Ali Ugur Unal 3, Asli Odabasi 4, Meryem Can 5, Ebru Asıcıoglu 6, Serhan Tuglular 6, Haner Direskeneli 3

Objectives: To determine the prevalence of vitamin D deficiency in patients with small and medium vessel systemic vasculitis.

Methods: In this cross-sectional study, 25-hydroxy (OH) vitamin D3 levels were measured in adult patients with systemic small and medium vessel vasculitis including antineutrophil cytoplasmic antibody-associated vasculitis (AAV), cryoglobulinaemic vasculitis (CryV), IgA vasculitis (IgAV) and polyarteritis nodosa (PAN), and age- and sex-matched healthy subjects (HS) and patients with rheumatoid arthritis (RA) as control groups. 25OH vitamin D3 levels<30ng/ml and <20ng/ml were regarded as insufficiency and deficiency, respectively.

Results: Fifty-seven patients (42 AAV, 2 CryV, 8 IgA vasculitis, 5 PAN) with systemic vasculitis, 101 HS, and 111 RA patients were included. The mean 25OH vitamin D3 level was

  • 21.8±14.2ng/mL in patients with vasculitis,
  • 42.7±27.6ng/mL in HS (p<.001) and
  • 20.1±18.47ng/mL in patients with RA (p=.54).

Vitamin D insufficiency and deficiency were significantly higher in patients with systemic vasculitis compared to HS (75.4% vs 33.7%, p<.001; %50 vs 21.8%, p<.001, respectively).
Vitamin D status was not different in patients with systemic vasculitis compared to RA. There was a negative correlation between vitamin D status and CRP levels (=-.364, p=.007).
The multivariate logistic regression analysis showed that renal involvement was significantly associated with vitamin D deficiency/insufficiency in patients with vasculitis (OR 22.5 [95% CI 1.6-128.9].

Conclusion: Vitamin D deficiency and insufficiency are more frequent in patients with systemic small and medium vessel vasculitis and RA than HS. Renal involvement is one of the factors associated with vitamin D deficiency/insufficiency in patients with vasculitis.


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Vasculitis on the web

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Wikipedia March 2022

  • "Vasculitis is a group of disorders that destroy blood vessels by inflammation.[2] Both arteries and veins are affected. Lymphangitis (inflammation of lymphatic vessels) is sometimes considered a type of vasculitis.[3] Vasculitis is primarily caused by leukocyte migration and resultant damage. Although both occur in vasculitis, inflammation of veins (phlebitis) or arteries (arteritis) on their own are separate entities."
  • According to the size of the vessel affected, vasculitis can be classified into:[7][8]
    • Large vessel: Takayasu's arteritis, Temporal arteritis
    • Medium vessel: Buerger's disease, Kawasaki disease, Polyarteritis nodosa
    • Small vessel: Behçet's syndrome, Eosinophilic granulomatosis with polyangiitis, Cutaneous vasculitis, granulomatosis with polyangiitis, Henoch–Schönlein purpura, and microscopic polyangiitis.


Vasculitis Foundation
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Leg Vasculitis
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Created by admin. Last Modification: Sunday March 13, 2022 16:16:54 GMT-0000 by admin. (Version 10)

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17219 Vasculitis image.jpg admin 13 Mar, 2022 16:01 12.93 Kb 166
17218 Vaculitis Foundation.jpg admin 13 Mar, 2022 16:01 26.18 Kb 157
17217 Vasculitis.webp admin 13 Mar, 2022 15:45 40.00 Kb 215