Role of Vitamin D in Uremic Vascular Calcification
BioMed Research International https://doi.org/10.1155/2017/2803579
Yi-Chou Hou ,1 Wen-Chih Liu ,2,3 Cai-Mei Zheng ,2,4,5 Jing-Quan Zheng,2,6 Tzung-Hai Yen ,7 and Kuo-Cheng Lu 1,2,8
Kidney problems are one of several health problems which result in less Vitamin D
Kidney category starts with
Kidney category listing hassee also Overview Kidney and vitamin D
Peritoneal dialysis in titles in VitaminDWiki (3 titles as of Oct 2021)
CKD or CHRONIC KIDNEY DISEASE in title of 65 pages as of Dec 2022
- Kidney Inflammation not reduced by 30 ng Vitamin D (many health problems need 50 ng) – Nov 2022
- Chronic Kidney Disease decreases Vitamin D in 4 ways – Nov 2017
- Half as much chronic kidney disease infection if supplement with Vitamin D – 2018
- 2.4 times more likely to die if have Chronic Kidney Disease and low vitamin D - Sept 2016
- 4X more Chronic Kidney disease patients are now using vitamin D – March 2014
- Poor kidneys rarely get enough or the right form of vitamin D – Feb 2019
Overview Kidney and vitamin D contains the following summary
- FACT: The Kidneys are not the primary way to activate vitamin D; the tissues are
- FACT: When the Kidney has problems, there is less active vitamin D (Calcitriol) for the body
- FACT: When the Kidney has problems, there is increased death due to many factors - many of which are associated with lack of Calcitriol
- FACT: There are many ongoing intervention clinical trials trying to determine how much of what kind of vitamin D is needed to treat the problem
- FACT: One Randomized Controlled Trial has proven that Vitamin D treats CKD
- FACT: 38% of seniors have Chronic Kidney Disease and most are unaware of it CDC statistics 2020
- FACT: Taking extra Vitamin D, in various forms, does not cause health problems - even if poor kidney
- Suggestion: Increase vitamin D getting into body now - and increase co-factors so that the vitamin D can be better used
Sun, UV lamp, Vitamin D supplement - probably > 5,000 IU,
Nanoemulstion vitamin D (inside cheek, topically) gets activated Vitamin D to the cells without the need for healthy kidney, liver, or intestine
Calcitriol - which bypasses the need for the kidney to activate vitamin D
Problems with Calcitriol however: typically only lasts for a few hours, also, possible complications
Update: Pre-cursor of active vitamin D made from plants is better than calcitriol – Sept 2012 - Category Kidney and Vitamin D contains
220 items Download the PDF from VitaminDWiki
The risk of cardiovascular death is 10 times higher in patients with CKD (chronic kidney disease) than in those without CKD. Vascular calcification, common in patients with CKD, is a predictor of cardiovascular mortality. Vitamin D deficiency, another complication of CKD, is associated with vascular calcification in patients with CKD. GFR decline, proteinuria, tubulointerstitial injury, and the therapeutic dose of active form vitamin D aggravate vitamin D deficiency and reduce its pleiotropic effect on the cardiovascular system. Vitamin D supplement for CKD patients provides a protective role in vascular calcification on the endothelium by
- (1) renin-angiotensin-aldosterone system inactivation,
- (2) alleviating insulin resistance,
- (3) reduction of cholesterol and inhibition of foam cell and cholesterol efflux in macrophages, and
- (4) modulating vascular regeneration.
For the arterial calcification, vitamin D supplement provides adjunctive role in regressing proteinuria, reverse renal osteodystrophy, and restoring calcification inhibitors. Recently, adventitial progenitor cell has been linked to be involved in the vascular calcification. Vitamin D may provide a role in modulating adventitial progenitor cells. In summary, vitamin D supplement may provide an ancillary role for ameliorating uremic vascular calcification.
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