25-Hydroxyvitamin-D deficiency in chronic kidney disease stages III, IV, and V in South Asian population: a retrospective cohort
SAGE Open Med 2023 Jan 19;11:20503121221148613. doi: 10.1177/20503121221148613
Muhammad Raheel Abdul Razzaque 1, Sameer Saleem Tebha 2, Alaa Tukruna 3, Aabiya Arif 4, Lucas Marian Kogut 5, Nasir Ali Afsar 6, Dania Shabbir 7, Zain Ali Zaidi 8
Objective: Vitamin D deficiency in Chronic Kidney Disease is a known fact, but the data regarding the prevalence and extent of vitamin D deficiency in different stages of Chronic Kidney Disease is scarce. This leads to a delay in addressing this issue. We conducted this study to assess vitamin-D deficiency in different stages of Chronic Kidney Disease to improve the evidence available to Physicians and Nephrologists which can help them better address this common finding in Chronic Kidney Disease.
Methods: This retrospective study from a tertiary care hospital in Karachi, Pakistan, included adult Chronic Kidney Disease patients who had their serum 25 Hydroxy vitamin D levels done. The patients were classified according to stages of Chronic Kidney Disease using Estimated Glomerular Filtration Rate values. Appropriate statistical tests were performed to find a correlation between the severity of vitamin D deficiency in different stages of Chronic Kidney Disease with a statistically significant p value of <0.05 and a 95% confidence interval.
Results: In total, 148 patients were included in the study. All patients had serum 25 Hydroxy vitamin D levels less than 30 ng/ml. The severity of vitamin D deficiency was observed to increase progressively from stage 3A Chronic Kidney Disease through stage 5. Vitamin D levels in Chronic Kidney Disease stage 3 were significantly greater than in Chronic Kidney Disease stages 4 and 5 (p value < 0.001), and stage 5 patients had the lowest vitamin D levels in our study. Similar, statistically significant findings were observed for serum phosphate levels, too, with stage 5 Chronic Kidney Disease patients having a greater serum phosphate concentration than stages 3A and 3B (p value = 0.002, 0.006).
Conclusion: All Chronic Kidney Disease patients in our study either had vitamin D insufficiency or deficiency. In addition, we observed a significant decrease in vitamin D levels from Chronic Kidney Disease stage 3 to stage 5. Greater serum phosphate levels were detected in stage 5 compared to stages 3A and 3B.
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66+ VitaminDWiki pages have CKD or CHRONIC KIDNEY DISEASE in title
This list is automatcially updated
Items found: 69
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1 in 10 have Chronic Kidney Disease (but only 5% are aware of it) – review Sept 2019 |
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30 Nov, 2023 |
Chronic Kidney disease 15 X more likely if Vitamin D deficient (Chinese males) – Sept 2023 |
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16 Sep, 2023 |
Chronic Kidney Disease needs Vitamin D: how much, what kind - many studies |
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27 Apr, 2023 |
Seniors raised Vitamin D levels, more COVID survivors, less CKD (Slovakia) – Feb 2023 |
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25 Feb, 2023 |
All children with Chronic Kidney Disease had low Vitamin D (Pakistan hospital) Jan 2023 |
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06 Feb, 2023 |
Hyperparathyroidism resulting from CKD eliminated by 8,000 IU of vitamin D daily for 12 weeks– RCT 2018 |
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13 Dec, 2022 |
Bone biomarkers increased equally by daily, weekly, or monthly Vitamin D (CKD in children in this case) – Nov 2022 |
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02 Nov, 2022 |
Calcitriol (active Vitamin D) prevents and treats COVID (with Chronic Kidney Disease in this case) June 2022 |
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05 Jul, 2022 |
Diabetics 5X more-likely to get CKD if have very low Vitamin D – June 2022 |
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30 Jun, 2022 |
Vitamin D treatment of Chronic Kidney Disease: monthly better than daily – RCT May 2022 |
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10 Jun, 2022 |
Chronic Kidney Disease study not aware of appropriate forms of vitamin D – March 2014 |
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10 Jun, 2022 |
4X more Chronic Kidney disease patients are now using vitamin D – March 2014 |
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10 Jun, 2022 |
Vitamin K2 MK- 7 not as available if have Chronic Kidney Disease - Nov 2021 |
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11 Nov, 2021 |
More people with Chronic Kidney Disease are now getting Vitamin D prescriptions (India) – Sept 2021 |
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05 Sep, 2021 |
Vitamin D testers have different test results if there is chronic kidney disease – Sept 2019 |
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16 Feb, 2021 |
Chronic Kidney Disease decreases Vitamin D in 4 ways – Nov 2017 |
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07 Jan, 2021 |
Chronic Kidney Disease (stage 3) slowed by 30 ng of Vitamin D and Calcitriol – Dec 2019 |
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06 Dec, 2019 |
Half as much chronic kidney disease infection if supplement with Vitamin D – 2018 |
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15 Mar, 2019 |
Chronic Kidney Disease Patients need Vitamin K – Jan 2019 |
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15 Feb, 2019 |
Chronic Kidney Disease patients need more than 20 ng of Vitamin D – workshop conclusion Oct 2018 |
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09 Oct, 2018 |
Hypothesis: Magnesium might prevent and treat Chronic Kidney Disease – April 2018 |
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09 Sep, 2018 |
Just 2 doses of Vitamin D resulted in many benefits (Chronic Kidney Disease)– Jan 2018 |
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06 Jan, 2018 |
Chronic Kidney Disease and Vitamin D Analogs – commentary Jan 2013 |
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27 Aug, 2017 |
Depression in Chronic Kidney Disease is predicted to be 6 times more likely if low vitamin D – Feb 2017 |
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25 Aug, 2017 |
Hemodialysis patients (CKD) helped by weekly 50,000 IU of vitamin D – Jan 2017 |
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27 Jul, 2017 |
2.4 times more likely to die if have Chronic Kidney Disease and low vitamin D - Sept 2016 |
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18 Jul, 2017 |
Chronic Kidney Disease mortality is 60 percent less likely if good vitamin D – meta-analysis July 2017 |
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18 Jul, 2017 |
50 percent of Chronic Kidney Disease treatments in Germany include vitamin D – Dec 2012 |
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13 Jul, 2017 |
Chronic Kidney disease in 20 percent of seniors in Taiwan – April 2017 |
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30 Apr, 2017 |
Standard oral vitamin D is not a good way to supplement if have Chronic Kidney Disease – March 2016 |
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20 Mar, 2017 |
Chronic Kidney disease not helped much by vitamin D provided you ignore dose size – meta-analysis Sept 2013 |
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01 Feb, 2017 |
7100 IU (50000 weekly) restored vitamin D levels for those with Chronic Kidney Disease – July 2012 |
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21 Sep, 2016 |
Chronic Kidney Disease not treated by 1400 IU of vitamin D – Nov 2015 |
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20 Nov, 2015 |
Magnesium reduced calcitriol (active vitamin D) artery calcification in CKD by 50 percent – Oct 2015 |
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22 Oct, 2015 |
Time-release form of active vitamin D granted a patent for chronic kidney disease – July 2014 |
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26 Jul, 2015 |
With CKD should measure the active form of vitamin D – April 2012 |
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26 Jul, 2015 |
Active vitamin D treats Chronic Kidney Disease by stimulating Klotho production – Dec 2012 |
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26 Jul, 2015 |
Some form of vitamin D may be the lowest cost treatment for CKD – Spanish Sept 2011 |
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16 Mar, 2015 |
Vitamin D and chronic kidney disease – July 2014 |
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18 Dec, 2014 |
HFCS or fructose decreases Calcium and vitamin D if have CKD – Feb 2010 |
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30 Jul, 2014 |
Chronic Kidney Disease reduced with 3600 IU vitamin D (50000 twice a month)– RCT Aug 2012 |
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11 Jun, 2014 |
Vitamin D receptor activation and Chronic Kidney Disease – Oct 2011 |
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14 May, 2014 |
4X more Chronic Kidney disease patients using vitamin D – March 2014 |
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11 Apr, 2014 |
Chronic Kidney disease patients increased use of vitamin D from 10 to 44 percent – March 2014 |
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11 Apr, 2014 |
Need at least 80 ng of vitamin D if have chronic kidney disease – May 2012 |
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08 Apr, 2014 |
Chronic Kidney Disease patients need more vitamin D and phosphate – Jan 2014 |
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09 Feb, 2014 |
Vascular calcification in chronic kidney disease April 2010 |
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21 Dec, 2013 |
Most Chronic Kidney Disease patients restored their vitamin D levels with just 1,000 IU – Dec 2013 |
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10 Dec, 2013 |
2000 IU vitamin D3 was not enough for children with chronic kidney disease – Feb 2013 |
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10 Dec, 2013 |
Chronic Kidney Disease clinical trials of UV in Germany – April 2013 |
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10 Nov, 2013 |
Inflammation and Vitamin D in Chronic Kidney Disease – May 2013 |
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02 Nov, 2013 |
Paricalcitol better than vitamin D2 for Chronic Kidney disease – April 2011 |
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13 Jul, 2013 |
Standard and artificial vitamin D both help Chronic Kidney Disease – meta-analysis April 2013 |
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24 Apr, 2013 |
Vitamin D reduced risk of death of Chronic Kidney Disease by 30 percent: Meta-analysis March 2013 |
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11 Mar, 2013 |
Chronic Kidney disease and low vitamin D in disadvantaged populations Nov 2010 |
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21 Jan, 2013 |
5700 IU of vitamin D helped half with chronic kidney disease if not having dialysis – July 2012 |
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01 Sep, 2012 |
Chronic kidney disease associated with higher levels of vitamin K1 – July 2012 |
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29 Jul, 2012 |
Chronic kidney disease and PTH – Calcium – Phosphate – Vitamin D – April 2011 |
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23 May, 2012 |
Perhaps Vitamin D3 is better than D2 for Chronic Kidney Disease – May 2012 |
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09 May, 2012 |
Chronic Kidney disease with low vitamin D causes health problems – April 2012 |
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18 Apr, 2012 |
Chronic Kidney Disease stage not associated with vitamin D levels – March 2012 |
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25 Mar, 2012 |
Death rate increased 3X for chronic kidney disease if low vitamin D – Nov 2011 |
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04 Nov, 2011 |
Vitamin D and Chronic Kidney Disease – Aug 2011 |
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02 Sep, 2011 |
Chronic Kidney Disease meta-analysis of vitamin D – Jan 2011 |
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11 Aug, 2011 |
Use of vitamin D in chronic kidney disease patients. – May 2010 |
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07 Aug, 2011 |
33 percent more likely to die of chronic kidney disease if less than 15 ng vitamin D – Aug 2011 |
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07 Aug, 2011 |
Chronic Kidney disease and vitamin D deficiency – Jan 2011 |
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08 Jan, 2011 |
Meta-analysis finds vitamin D helps chronic kidney disease – Sept 2010 |
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06 Oct, 2010 |
Therapeutic window for vitamin D and chronic kidney disease |
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25 Apr, 2010 |
VitaminDWiki – Kidney category contains
- FACT: The Kidneys are not the primary way to activate vitamin D; the tissues are
- FACT: When the Kidney has problems, there is less active vitamin D (Calcitriol) for the body
- FACT: When the Kidney has problems, there is increased death due to many factors - many of which are associated with lack of Calcitriol
- FACT: There are many ongoing intervention clinical trials trying to determine how much of what kind of vitamin D is needed to treat the problem
- FACT: One Randomized Controlled Trial has proven that Vitamin D treats CKD
- FACT: 38% of seniors have Chronic Kidney Disease and most are unaware of it CDC statistics 2020
- FACT: Taking extra Vitamin D, in various forms, does not cause health problems - even if poor kidney
- Suggestion: Increase vitamin D getting into body now - and increase co-factors so that the vitamin D can be better used
Sun, UV lamp, Vitamin D supplement - probably > 5,000 IU,
Nanoemulstion vitamin D (inside cheek, topically) gets activated Vitamin D to the cells without the need for healthy kidney, liver, or intestine
Calcitriol - which bypasses the need for the kidney to activate vitamin D
Problems with Calcitriol however: typically only lasts for a few hours, also, possible complications
Update: Pre-cursor of active vitamin D made from plants is better than calcitriol – Sept 2012
- Category Kidney and Vitamin D contains
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