An Update on the Effects of Vitamin D on the Immune System and Autoimmune Diseases
Int J Mol Sci. 2022 Aug 29;23(17):9784 doi: 10.3390/ijms23179784.
Claudia Sîrbe 1 2 , Simona Rednic 3 4 , Alina Grama 1 2 , Tudor Lucian Pop 1 2
PDF Table of Contents
Vitamin D intervenes in calcium and phosphate metabolism and bone homeostasis. Experimental studies have shown that 1,25-dihydroxyvitamin D (calcitriol) generates immunologic activities on the innate and adaptive immune system and endothelial membrane stability. Low levels of serum 25-hydroxyvitamin D (25(OH)D) are associated with an increased risk of developing immune-related diseases such as psoriasis, type 1 diabetes, multiple sclerosis, and autoimmune diseases. Various clinical trials describe the efficacy of supplementation of vitamin D and its metabolites for treating these diseases that result in variable outcomes. Different disease outcomes are observed in treatment with vitamin D as high inter-individual difference is present with complex gene expression in human peripheral blood mononuclear cells. However, it is still not fully known what level of serum 25(OH)D is needed. The current recommendation is to increase vitamin D intake and have enough sunlight exposure to have serum 25(OH)D at a level of 30 ng/mL (75 nmol/L) and better at 40-60 ng/mL (100-150 nmol/L) to obtain the optimal health benefits of vitamin D.
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VitaminDWiki - Autoimmune category contains
188 items in Autoimmune category - Vitamin D and MS Asthma RA Diabetes Gut Allergy Hay Fever Muscular Dystrophy Lupus Psoriasis
- Autoimmune disease clusters run in families having low D
- How Vitamin D reduces inflammation, improves immunity and fights autoimmunity – review Dec 2018
- 120 doctors and 20,000 MS patients using high dose Vitamin D Dec 2018
- Vitamin D has treated Multiple Sclerosis and autoimmune diseases for 16 years – Coimbra April 2018
- Vitamin D Receptor is associated in over 58 autoimmune studies
- Many autoimmune diseases associated with low vitamin D or poor Vit D genes – July 2019
Vitamin D needed to TREAT Health problems 30 ng rickets, 150 ng MS
Vitamin D Treats 150 ng Multiple Sclerosis * 80 ng Cluster Headache *
Reduced office visits by 4X *70 ng Sleep * 60 ng Breast Cancer death reduced 60%
Preeclampsia RCT50 ng COVID-19
Fertility
Psoriasis
Infections Review
Infection after surgery40 ng Breast Cancer 65% lower risk
Depression
ACL recovery
Hypertension
Asthma?30 ng Rickets * Evolution of experiments with patients, often also need co-factors
Autoimmune diseases fought by Vitamin D, especially if have more than 40 ng – Sept 2022244 visitors, last modified 16 Sep, 2022, This page is in the following categories (# of items in each category)Attached files
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