An Bras Dermatol. 2021 Mar 24;S0365-0596(21)00074-X. doi: 10.1016/j.abd.2020.10.002
Seshadri Reddy Varikasuvu 1, Sowjanya Aloori 2, Saurabh Varshney 3, Aparna Varma Bhongir
The medical profession moves V E R Y S L O W L Y
A decade of studies noted the assoication of low vitamin D and vitiligo
Even this paper took 7 month to be published after being received
- Vitiligo (spotty skin coloring) is 4 X more likely if poor Vitamin D Receptor – meta-analysis July 2018
- Vitamin D Receptor is associated in over 58 autoimmune studies - such as vitiligo
- Note: There are 12+ easy ways to increase vitamin D receptor activation
- Vitiligo is associated with low vitamin D (nothing about treatment) – meta-analysis March 2016
- Vitiligo (loss of skin pigment) treated by narrowband UVB
- 35,000 IU vitamin D daily for 6 months helped ALL psoriasis suffers (106 ng) – Brazil March 2013
- Many Vitiligo patients were helped by Vitamin D
Background: The serum Vitamin D status in patients with vitiligo is ambiguous when compared to controls. A systematic review and updated meta-analysis were conducted to evaluate the association between Vitamin D and vitiligo.
Methods: Relevant studies were identified by searching PubMed and other databases. The random effects model was used to obtain standardized mean differences and pooled correlation coefficients. Meta-regression and sub-group analyses were conducted to explore heterogeneity. The presence of publication bias and the study robustness were tested using funnel plot and sensitivity analyses, respectively.
Results: This meta-analysis finally included 31 studies. Compared with controls, vitiligo patients showed significantly decreased serum Vitamin D levels (standardized mean difference = -1.03; p < 0.0001). The sub-group analysis showed that vitiligo patients with indoor/urban work had a significantly lower Vitamin D level when compared to their outdoor/rural counterparts (standardized mean differences = -0.45; p = 0.03). The sensitivity analysis indicated that no single study had a significant influence on the overall outcome, suggesting the robustness of this meta-analysis.
Study limitations: Varied sample sizes and heterogeneous study populations from different countries are the limitations of this study. However, the between-study heterogeneity has been addressed by the random-effects model with meta-regression and sensitivity analyses.
Conclusions: This meta-analysis showed significantly decreased Vitamin D level in vitiligo, and its association with indoor/outdoor type of work of vitiligo patients. This study highlights the need to assess Vitamin D status for improving its level in vitiligo.