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Resveratrol improves health (Vitamin D receptor, etc.)


  • The Vitamin D Receptor can restrict how much of the Vitamin D in the blood actually gets to cells
  • Resveratrol is one of 11 ways to negate the Vitamin D Receptor restrictions
  • Resveratrol is produced by several plants in response to injury or, when the plant is under attack by pathogens such as bacteria or fung
  • Benefits of Reseveratrol, like Vitamin D, appears to be increased when used with other things
    • Quercetin and Curcumin in the case of Resveratro

The articles in both of the categories Resveratrol and Vitamin D Receptor

24 Resveratrol articles

See also VitaminDWiki

Reductions in Vitamin D is.gd/VitDReductions


Vitamin D Receptor category

299 items in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population has a poor VDR (40% of the Obese )

A poor VDR increases the risk of 53 health problems  click here for details

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

Compensate for poor VDR by increasing one or more:

IncreasingIncreases
1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
etc
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentation Vitamin D
Increases the concentration gradient
Vitamin D in the cells

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements which help the VDR


Genetics category

244 articles in the Genetics category

see also 299 articles in Vitamin D Receptor, 113 articles in Vitamin D Binding Protein

Vitamin D blood test misses a lot
Blood Test Misses a lot (VDW 3439)

  • Snapshot of the literature by VitaminDWiki - (subject to many future developments)
  • Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, andi in 2017 is speculated to be 90%
  • Note: Good results from a blood test (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
  • A Vitamin D test in cells appears feasible (personal communication)
    However test results would vary in each tissue due to multiple genes
  • Good clues that Vitamin D is being restricted from getting to the cells
    1) A vitamin D-related health problem runs in the family
       especially if it is one of 51+ diseases related to Vitamin D Receptor
    2) Slightly increasing Vitamin D show benefits (even if conventional Vitamin D test shows an increase)
    3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016
        easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018
    4) Back Pain
        probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
          The founder of VitaminDWiki took action with clues #3&4

PubMed

3X increase in publications which include the word RESVERATROL in 13 years
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  • Resveratrol: Twenty Years of Growth, Development and Controversy - Jan 2019
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  • Resveratrol potentiates vitamin D and nuclear receptor signaling - June 2015, doi: 10.1002/jcb.25070
  • Evidence-based nutritional and pharmacological interventions targeting chronic low-grade inflammation in middle-age and older adults: A systematic review and meta-analysis Sept 2018, doi: 10.1016/j.arr.2018.05.004
  • Vitamin D Combined with Resveratrol Prevents Cognitive Decline in SAMP8 Mice. 2017 10.2174/1567205014666170207093455
  • New strategies in sport nutrition to increase exercise performance Sept 2016 doi: 10.1016/j.freeradbiomed.2016.01.016 free PDF
  • New concepts and challenges in the clinical translation of cancer preventive therapies: the role of pharmacodynamic biomarkers Nov 2015 doi: 10.3332/ecancer.2015.601 free PDF
  • Nutritional treatment for acute and chronic traumatic brain injury patients Sept 2014
    • They found improvements by Reseveratrol, Omega-3, Magnesium, all of which improve the amount of Vitamin D getting to cells
  • Resveratrol: A Double-Edged Sword in Health Benefits Sept 2018 10.3390/biomedicines6030091
    • "Nonetheless, resveratrol application is still being a major challenge for pharmaceutical industry, due to its poor solubility and bioavailability, as well as adverse effects"
    •  Download the PDF from VitaminDWiki
  • Resveratrol-loaded nanoemulsion prevents cognitive decline after abdominal surgery in aged rats Aug 2018 doi: 10.1016/j.jphs.2018.08.006
  • Increased Oral Bioavailability of Resveratrol by Its Encapsulation in Casein Nanoparticles doi Sept 2018 10X increase in bio-availability
  • Developmental Programming of the Metabolic Syndrome: Can We Reprogram with Resveratrol? Aug 2017 doi: 10.3390/ijms19092584 free PDF
  • Resveratrol and Depression in Animal Models: A Systematic Review of the Biological Mechanisms| Aug 2018 10.3390/molecules23092197 free PDF
  • Resveratrol Supplementation Reduces Pain and Inflammation in Knee Osteoarthritis Patients Treated with Meloxicam: A Randomized Placebo-Controlled Study Aug 2018 10.1089/jmf.2017.4176
  • Resveratrol Counteracts Insulin Resistance-Potential Role of the Circulation Aug 2018 doi: 10.3390/nu10091160 free PDF
  • Resveratrol: an effective pharmacological agent to prevent inflammation-induced atrial fibrillation? Sept 2017 doi: 10.1007/s00210-018-1566-5 Free PDF
  • Resveratrol prevents atrial fibrillation by inhibiting atrial structural and metabolic remodeling in collagen-induced arthritis rats Aug 2018 doi: 10.1007/s00210-018-1554-9
  • Pleiotropic mechanisms facilitated by resveratrol and its metabolites - July 2010

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Web

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summarized from: Long-Term Resveratrol Supplementation as a Secondary Prophylaxis for Stroke
 Download the PDF from VitaminDWiki


RESVERATROL: REWRITING THE SCIENCE, Oct, 2018: by Bill Sardi

Far more on web

  • Over 7 million results for “resveratrol” on the Google search engine. Sixty years of research; 133 human clinical trials; twenty thousand (20,000) published research papers plus symposia, conferences, patents and attempts to produce analog drugs (synthetic resveratrol-like molecules).
  • 20 different diseases associated with aging. The current paradigm of one drug for one disease in modern medicine would be disrupted.

Heart disease: resveratrol remains on the sidelines
To put it bluntly, many people are having heart attacks and dying needlessly for the lack of resveratrol.
Resveratrol for longevity: will it ever be put to the test?

  • The real problem is, if you fix aging, you fix virtually every chronic age-related disease, which represents most of the income and profits generated by the healthcare industry.

Molecular promiscuity

  • Resveratrol combined with quercetin and rice bran IP6 far exceeded the biological action of a life-long CR diet in only 12 weeks.

Resveratrol: is/isn’t bioavailable

  • Pezzuto's paper does mention the fact a black pepper extract (piperine) allows more resveratrol to pass through the liver and be initially bioavailable before all resveratrol is metabolized. Quercetin is another molecule that does this also.

Resveratrol and diabetes

  • A lab dish study demonstrated that resveratrol “completely substitutes for insulin.” A review of 11 published human studies reveals resveratrol significantly reduces fasting glucose (blood sugar), insulin, oxidized (glycated) hemoglobin, and insulin resistance levels among diabetics. But resveratrol was mischaracterized as being ineffective when it didn't lower blood sugar levels in healthy individuals - i.e. it doesn't induce hypoglycemia. (That sounds like an added level of safety.)

Molecular synergism

  • It has been authoritatively documented that individual doses of resveratrol, quercetin and catechin were ineffective in reducing cancer in laboratory mice but the combination of these three molecules demonstrably reduces tumor growth. Recall the animal lab study where three molecules (resveratrol, quercetin, IP6 rice bran) activated 1711 genes compared to just 225 for plain resveratrol over a 12- week period. Molecular synergism is well validated.

Dose response

  • The human equivalent dose of 175 and 350 milligrams of resveratrol protected heart muscle from reperfusion (re-supply of oxygen) damage. The combination of resveratrol + quercetin + IP6 rice bran produced a more protective effect (millions more heart muscle cells survived and did not produce scar tissue -fibrosis).

Resveratrol: Safe but not without side effects
Some 531 available brands of resveratrol pills
Resveratrol: nothing more than snake oil?
Extortion by another name
No better than placebo?

How the world got lost on the road to an anti-aging pill (Resveratrol) - ebook by Bill Sardi
 Download the PDF from VitaminDWiki

Resveratrol inhibits the formation of new blood vessels (aka angiogenesis or neovascularization) at the back of the eyes.
One brand of resveratrol (Longevinex®,) has been reported in a pilot study to improve various measures of vision in 16 of 17 subjects.
http://longevinex.com/ ~$1/capsule

Company selling Resveratrol

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There have actually been 1478 visitors to this page since it was originally made

Short URL = is.gd/Resveratrol_VDR

Created by admin. Last Modification: Monday June 24, 2019 18:25:18 GMT-0000 by admin. (Version 50)

Attached files

ID Name Comment Uploaded Size Downloads
11897 Resveratrol in food.jpg admin 03 May, 2019 16:06 86.70 Kb 178
11866 howTheWorldGotLost.pdf admin 29 Apr, 2019 02:14 1.88 Mb 52
11862 Resveratrol PubMed.jpg admin 28 Apr, 2019 19:09 2.41 Kb 177
11411 R publications.jpg admin 16 Feb, 2019 19:06 50.86 Kb 236
11410 Resveratrol - Twenty Years of Growth, Development and Controversy.pdf PDF 2019 admin 16 Feb, 2019 19:00 926.51 Kb 34
11409 Pleiotropic R.jpg admin 16 Feb, 2019 18:43 54.38 Kb 234
11408 Pleiotropic mechanisms.pdf admin 16 Feb, 2019 18:42 1.15 Mb 32
11407 High Potency R.jpg admin 16 Feb, 2019 18:38 57.38 Kb 251
11406 Resveratrol stroke study.pdf admin 16 Feb, 2019 17:10 1.52 Mb 34
11405 Resveratrol stroke.jpg admin 16 Feb, 2019 17:09 59.29 Kb 237
10582 Resveratrol-loaded nanoemulsion.pdf PDF 2018 admin 22 Sep, 2018 15:10 1.72 Mb 91
10581 Challenge.pdf PDF 2018 admin 22 Sep, 2018 15:01 869.86 Kb 70
10580 Resveratrol encapsulation-min.pdf PDF 2018 admin 22 Sep, 2018 14:36 494.17 Kb 97
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