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Resveratrol improves health (Vitamin D receptor, etc.)

  • The Vitamin D Receptor can restrict how much of the Vitamin D in the blood actually gets to cells
  • Resveratrol is one of 11 ways to negate the Vitamin D Receptor restrictions
  • Resveratrol is produced by several plants in response to injury or, when the plant is under attack by pathogens such as bacteria or fung
  • Benefits of Reseveratrol, like Vitamin D, appears to be increased when used with other things
    • Quercetin and Curcumin in the case of Resveratro
18 articles in both of the categories Resveratrol and Vitamin D Receptor

47 Resveratrol articles

See also VitaminDWiki

Reductions in Vitamin D is.gd/VitDReductions

Vitamin D Receptor category

494 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 47 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
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The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (18 studies), Breast Cancer (20 studies), Colon Cancer (13 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (23 studies), Hypertension (9 studies), Infant (21 studies), Lupus (6 studies), Metabolic Syndrome (3 studies), Mortality (4 studies), Multiple Sclerosis (11 studies), Obesity (15 studies), Pregnancy (24 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (33 studies),   Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation

55 health problems associated with poor VDR

A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

How to increase VDR activation

Compensate for poor VDR by increasing one or more:

1) Vitamin D supplement  Sun
Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D Receptor
13) Sulfroaphane and perhaps sulfurVitamin D Receptor
14)Butyrate especially gutVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR

Genetics category

326 articles in the Genetics category

see also

Vitamin D blood test misses a lot
in Visio for 2023

  • Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
  • Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
  • A Vitamin D test in cells rather than blood was feasible (2017 personal communication)
  •    Commercially available 2019
    • However, test results would vary in each tissue due to multiple genes
  • Good clues that Vitamin D is being restricted from getting to the cells
    1) A vitamin D-related health problem runs in the family
    2) Slightly increasing Vitamin D shows benefits (even if conventional Vitamin D test shows an increase)
    3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016
    • easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018

    4) Back Pain

Influence of Resveratrol on the Immune Response (Nothing about Vitamin D)- April 2019

 Download the PDF from VitaminDWiki

Multiplicity of effects and health benefits of resveratrol – April 2015

Medicina 2016, 52(3), 148-155; https://doi.org/10.1016/j.medici.2016.03.003
by Lolita Kuršvietienė 1,*,Inga Stanevičienė 1,2,Aušra Mongirdienė 1,3 andJurga Bernatonienė 4
1 Department of Biochemistry, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
2 Laboratory of Molecular Neurobiology, Neuroscience Institute, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
3 Laboratory of Molecular Cardiology, Institute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania
4 Department of Drug Technology and Social Pharmacy, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania

Resveratrol is mainly found in grapes and red wine, also in some plants and fruits, such as peanuts, cranberries, pistachios, blueberries and bilberries. Moreover, nowadays this compound is available as purified preparation and dietary supplement. Resveratrol provides a wide range of benefits, including

  • cardiovascular protective,
  • antiplatelet,
  • antioxidant,
  • antiinflammatory,
  • blood glucose-lowering and
  • anticancer activities,

hence it exhibits a complex mode of action. During the recent years, these properties have been widely studied in animal and human models, both in vitro and in vivo. This paper is intended to present information published during the recent years on the biological activities and multiple effects of resveratrol.
 Download the PDF from VitaminDWiki


3X increase in publications which include the word RESVERATROL in 13 years

  • Resveratrol: Twenty Years of Growth, Development and Controversy - Jan 2019
  • Image
  • Resveratrol potentiates vitamin D and nuclear receptor signaling - June 2015, doi: 10.1002/jcb.25070
  • Enhancing the Delivery of Resveratrol in Humans:If Low Bioavailability is the Problem, What is the Solution? - 2014
  • Evidence-based nutritional and pharmacological interventions targeting chronic low-grade inflammation in middle-age and older adults: A systematic review and meta-analysis Sept 2018, doi: 10.1016/j.arr.2018.05.004
  • Vitamin D Combined with Resveratrol Prevents Cognitive Decline in SAMP8 Mice. 2017 10.2174/1567205014666170207093455
  • New strategies in sport nutrition to increase exercise performance Sept 2016 doi: 10.1016/j.freeradbiomed.2016.01.016 free PDF
  • New concepts and challenges in the clinical translation of cancer preventive therapies: the role of pharmacodynamic biomarkers Nov 2015 doi: 10.3332/ecancer.2015.601 free PDF
  • Nutritional treatment for acute and chronic traumatic brain injury patients Sept 2014
    • They found improvements by Reseveratrol, Omega-3, Magnesium, all of which improve the amount of Vitamin D getting to cells
  • Resveratrol: A Double-Edged Sword in Health Benefits Sept 2018 10.3390/biomedicines6030091
    • "Nonetheless, resveratrol application is still being a major challenge for pharmaceutical industry, due to its poor solubility and bioavailability, as well as adverse effects"
    •  Download the PDF from VitaminDWiki
  • Resveratrol-loaded nanoemulsion prevents cognitive decline after abdominal surgery in aged rats Aug 2018 doi: 10.1016/j.jphs.2018.08.006
  • Increased Oral Bioavailability of Resveratrol by Its Encapsulation in Casein Nanoparticles doi Sept 2018 10X increase in bio-availability
  • Developmental Programming of the Metabolic Syndrome: Can We Reprogram with Resveratrol? Aug 2017 doi: 10.3390/ijms19092584 free PDF
  • Resveratrol and Depression in Animal Models: A Systematic Review of the Biological Mechanisms| Aug 2018 10.3390/molecules23092197 free PDF
  • Resveratrol Supplementation Reduces Pain and Inflammation in Knee Osteoarthritis Patients Treated with Meloxicam: A Randomized Placebo-Controlled Study Aug 2018 10.1089/jmf.2017.4176
  • Resveratrol Counteracts Insulin Resistance-Potential Role of the Circulation Aug 2018 doi: 10.3390/nu10091160 free PDF
  • Resveratrol: an effective pharmacological agent to prevent inflammation-induced atrial fibrillation? Sept 2017 doi: 10.1007/s00210-018-1566-5 Free PDF
  • Resveratrol prevents atrial fibrillation by inhibiting atrial structural and metabolic remodeling in collagen-induced arthritis rats Aug 2018 doi: 10.1007/s00210-018-1554-9
  • Pleiotropic mechanisms facilitated by resveratrol and its metabolites - July 2010



summarized from: Long-Term Resveratrol Supplementation as a Secondary Prophylaxis for Stroke
 Download the PDF from VitaminDWiki

Found My Fitness ( Dr. Patrick) on Reseveratrol

Resveratrol - 2019?
1Resveratrol's effects on human health and disease
1.1Metabolic and cardiovascular health and markers of inflammation
1.2Neurological health and Alzheimer’s disease
2 Physiological responses and molecular mechanisms associated with resveratrol intake
2.1Sirtuin activation
2.2Autophagy activation
2.3Resveratrol as an insect antifeedant and its role in xenohormesis
2.4Resveratrol as a calorie restriction mimetic
2.5Exercise performance enhancement from resveratrol
2.6Resveratrol supplementation and safety
•Resveratrol news
Podcast Jan 2020 - for subscribers only
00:03:39 - Clinical effects of resveratrol in humans
00:04:10 - Effects on cardiovascular health biomarkers in humans
00:06:54 - Reduction of inflammatory biomarkers in humans
00:08:11 - Improved cognition and memory in clinical studies
00:11:23 - Healthspan improvements in animals
00:12:28 - Induction of longevity genes via xenohormesis
00:16:19 - Contradictory effects on exercise-associated benefits
00:20:34 - Various factors that affect resveratrol bioavailability
00:23:09 - Unintentional effects on drug metabolism
   no apparent mention that Resveratrol increases the Vitamin D Receptor



Chart of Resveratrol benefits - Natural Biology

They sell it

Resveratrol, being a phytoestrogen, DECREASED Breast Cancer survival by 19% - Nov 2019

Increasing levels of resveratrol, genistein, or luteolin linked to worse five-year breast cancer survival

Resveratrol oral and topical forms that are more bio-available

Strategies to Improve Resveratrol Systemic and Topical Bioavailability: An Update - July 2019
 Download the PDF from VitaminDWiki
No mention of the Vitamin D Receptor
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Turmeric is as Effective as 14 Drugs (Turmeric also increases VDR activation) - March 2021


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Resveratrol improves health (Vitamin D receptor, etc.)        
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Attached files

ID Name Comment Uploaded Size Downloads
17526 Resveratrol 2016.pdf admin 29 Apr, 2022 13:09 392.51 Kb 182
15439 Resveratrol health benefits.pdf admin 14 Apr, 2021 23:35 914.35 Kb 329
13316 Resveratrol Bioavailability.jpg admin 11 Jan, 2020 20:35 48.57 Kb 2553
13315 Resveratrol Bioavailability including Topical_compressed.pdf admin 11 Jan, 2020 20:29 629.56 Kb 523
13118 Resveratrp; effects.jpg admin 08 Dec, 2019 19:24 146.93 Kb 2553
13117 Resveratrol influences.jpg admin 08 Dec, 2019 19:24 74.01 Kb 2606
13116 Influence of Resveratrol on the Immune Response.pdf admin 08 Dec, 2019 19:23 1.43 Mb 527
12372 Resveratrol bioavailability.pdf admin 20 Jul, 2019 16:18 264.81 Kb 613
11897 Resveratrol in food.jpg admin 03 May, 2019 16:06 86.70 Kb 3287
11862 Resveratrol PubMed.jpg admin 28 Apr, 2019 19:09 2.41 Kb 2777
11411 R publications.jpg admin 16 Feb, 2019 19:06 50.86 Kb 2925
11410 Resveratrol - Twenty Years of Growth, Development and Controversy.pdf PDF 2019 admin 16 Feb, 2019 19:00 926.51 Kb 811
11409 Pleiotropic R.jpg admin 16 Feb, 2019 18:43 54.38 Kb 2772
11408 Pleiotropic mechanisms.pdf admin 16 Feb, 2019 18:42 1.15 Mb 850
11407 High Potency R.jpg admin 16 Feb, 2019 18:38 57.38 Kb 3076
11406 Resveratrol stroke study.pdf admin 16 Feb, 2019 17:10 1.52 Mb 851
11405 Resveratrol stroke.jpg admin 16 Feb, 2019 17:09 59.29 Kb 2783
10582 Resveratrol-loaded nanoemulsion.pdf PDF 2018 admin 22 Sep, 2018 15:10 1.72 Mb 837
10581 Challenge.pdf PDF 2018 admin 22 Sep, 2018 15:01 869.86 Kb 830
10580 Resveratrol encapsulation-min.pdf PDF 2018 admin 22 Sep, 2018 14:36 494.17 Kb 790