Loading...
 
Toggle Health Problems and D

Role of Vitamin D in the Pathogenesis of Diabetes – Holick July 2017

Principles of Diabetes Mellitus, pp 107-119, 08 July 2017
Nadine E. Palermo , Michael F. Holick

See also VitaminDWiki

Search VitaminDWiki for HOLICK DIABETES 1860 items as of July 2017

Overview Diabetes and vitamin D contains this summary]

  • Diabetes is 5X more frequent far from the equator
  • Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
  • Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
  • Sedentary people get less sun / Vitamin D
  • Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
  • Elderly get 4X less vitamin D from the same amount of sun
        Elderly also spend less time outdoors and have more clothes on
  • All items in category Diabetes and Vitamin D 548 items: both Type 1 and Type 2

Vitamin D appears to both prevent and treat diabetes

Number of articles in both categories of Diabetes and:

  • Dark Skin 24;   Intervention 56;   Meta-analysis 39;   Obesity 36;  Pregnancy 44;   T1 (child) 39;  Omega-3 11;  Vitamin D Receptor 24;  Genetics 13;  Magnesium 29    Click here to see details

Some Diabetes studies

50 ng of Vitamin D fights Diabetes

T1 Diabetes

Pre-Diabetes

Diabetes, Metabolic Syndrome and Magnesium - many studies


Pages listed in BOTH of the categories Diabetes and Intervention


Pages listed in BOTH of the categories Diabetes and Meta-analysis


With the predicted continued rise in patients diagnosed with diabetes and anticipated progressive loss of beta cell function in those already affected, there has been ongoing interest in understanding the mechanism of pathogenesis as well as identifying factors that may modulate dysglycemia.
Several observational and interventional studies have sought to demonstrate improvement in glycemic control and insulin sensitivity based on vitamin D status.
While this relationship has not been consistently seen in medical literature, is it likely due to the

  • duration of intervention,
  • dose and underlying vitamin D status

as the most pronounced effect of vitamin D supplementation on glycemic control has been observed in patients with vitamin D deficiency/insufficiency and who do not have established diabetes.

Evidence suggests that vitamin D’s effect on the immune system may play a role in reducing risk for developing type 1 diabetes. Therefore, improvement in vitamin D status throughout life may help reduce risk for developing both type 1 and type 2 diabetes as well as improve glycemic control in those who have these disorders.

References

  • 1. International Diabetes Federation Annual Report. 2014. http://​www.​idf.​org/​sites/​default/​files/​IDF-2014-Annual-Report-final.​pdf. Accessed 31 Jan 2016
  • 2. CDC National Diabetes Statistics Report. http://​www.​cdc.​gov/​diabetes/​data/​statistics/​2014StatisticsRe​port.​html. Accessed 20 Mar 2016
  • 3. Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Study Research Group. Intensive diabetes treatment and cardiovascular outcomes in Type 1 diabetes: the DCCT/EDIC study 30-year follow-up. Diabetes Care. 2016;39(5):686–93
  • 4. Holman RR, Paul SK, Bethel MA, Matthews DR, Neil HA. 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med. 2008;359(15):1577–89.CrossRefPubMed
  • 5. Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM. Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002;346(6):393–403.CrossRefPubMed
  • 6. Hossein-nezhad A, Holick MF. Vitamin D for health: a global perspective. Mayo Clin Proc. 2013;88(7):720–55.CrossRefPubMedPubMedCentral
  • 7. Holick MF. Vitamin D, deficiency. N Engl J Med. 2007;357(3):266–81.CrossRefPubMed
  • 8. Holick MF. Vitamin D: a millenium perspective. J Cell Biochem. 2003;88(2):296–307.CrossRefPubMed
  • 9. Haddad JG, Walgate J, Min C, Hahn TJ. Vitamin D metabolite-binding proteins in human tissue. Biochim Biophys Acta. 1976;444(3):921–5.CrossRefPubMed
  • 10. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM. Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911–30.CrossRefPubMed
  • 11. Palermo NE, Holick MF. Vitamin D, bone health, and other health benefits in pediatric patients. J Pediatr Rehabil Med. 2014;7(2):179–92.PubMed
  • 12. Adams JS, Hewison M. Update in vitamin D. J Clin Endocrinol Metab. 2010;95(2):471–8.CrossRefPubMedPubMedCentral
  • 13. Mathieu C. Vitamin D, and diabetes: where do we stand? Diabetes Res Clin Pract. 2015;108(2):201–9.CrossRefPubMed
  • 14. Hossein-nezhad A, Holick MF. Optimize dietary intake of vitamin D: an epigenetic perspective. Curr Opin Clin Nutr Metab Care. 2012;15(6):567–79.CrossRefPubMed
  • 15. Park S, da Kim S, Kang S. Vitamin D deficiency impairs glucose-stimulated insulin secretion and increases insulin resistance by reducing PPAR-γ expression in nonobese Type 2 diabetic rats. J Nutr Biochem. 2016;27:257–65.CrossRefPubMed
  • 16. Institute of Medicine (IOM). Dietary reference intakes for calcium and vitamin D. Committee to review dietary reference intakes for calcium and vitamin D. Washington, DC: The National Academies Press, Institute of Medicine; 2011. 17. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM. Guidelines for preventing and treating vitamin D deficiency and insufficiency revisited. J Clin Endocrinol Metab. 2012;97(4):1153–8.CrossRefPubMed
  • 18. Rosen CJ, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu RA, Gallagher JC, Gallo RL, Jones G, Kovacs CS, Manson JE, Mayne ST, Ross AC, Shapses SA, Taylor CL. IOM committee members respond to Endocrine Society vitamin D guideline. J Clin Endocrinol Metab. 2012;97(4):1146–52.CrossRefPubMedPubMedCentral
  • 19. Van Belle TL, Gysemans C, Mathieu C. Vitamin D in autoimmune, infectious and allergic diseases: a vital player? Best Pract Res Clin Endocrinol Metab. 2011;25(4):617–32.CrossRefPubMed
  • 20. Baeke F, Takiishi T, Korf H, Gysemans C, Mathieu C. Vitamin D: modulator of the immune system. Curr Opin Pharmacol. 2010;10(4):482–96.CrossRefPubMed
  • 21. Mohr SB, Garland CF, Gorham ED, Garland FC. The association between ultraviolet B irradiance, vitamin D status and incidence rates of type 1 diabetes in 51 regions worldwide. Diabetologia. 2008;51(8):1391–8.CrossRefPubMed
  • 22. Vitamin D. Supplement in early childhood and risk for Type I (insulin-dependent) abetes mellitus. The EURODIAB Substudy 2 Study Group. Diabetologia. 1999;42(1):51–4.CrossRef
  • 23. Samuelsson U, Carstensen J, Löfman O, Nordfeldt S. Seasonal variation in the diagnosis of type 1 diabetes in south-east Sweden. Diabetes Res Clin Pract. 2007;76(1):75–81.CrossRefPubMed
  • 24. Karvonen M, Viik-Kajander M, Moltchanova E, Libman I, LaPorte R, Tuomilehto J. Incidence of childhood type 1 diabetes worldwide. Diabetes Mondiale (DiaMond) Project Group. Diabetes Care. 2000;23(10):1516–26.CrossRefPubMed
  • 25. Knekt P, Laaksonen M, Mattila C, Härkänen T, Marniemi J, Heliövaara M, Rissanen H, Montonen J, Reunanen A. Serum vitamin D and subsequent occurrence of type 2 diabetes. Epidemiology. 2008;19(5):666–71.CrossRefPubMed
  • 26. Liu E, Meigs JB, Pittas AG, Economos CD, McKeown NM, Booth SL, Jacques PF. Predicted 25-hydroxyvitamin D score and incident type 2 diabetes in the Framingham Offspring Study. Am J Clin Nutr. 2010;91(6):1627–33.CrossRefPubMedPubMedCentral
  • 27. Nordfeldt S, Ludvigsson J. Seasonal variation of HbA1c in intensive treatment of children with type 1 diabetes. J Pediatr Endocrinol Metab. 2000;13(5):529–35.CrossRefPubMed
  • 28. Braatvedt GD, Mildenhall L, Patten C, Harris G. Insulin requirements and metabolic control in children with diabetes mellitus attending a summer camp. Diabet Med. 1997;14(3):258–61.CrossRefPubMed
  • 29. Gikas A, Sotiropoulos A, Pastromas V, Papazafiropoulou A, Apostolou O, Pappas S. Seasonal variation in fasting glucose and HbA1c in patients with type 2 diabetes. Prim Care Diabetes. 2009;3(2):111–4. Jun 16.CrossRefPubMed
  • 30. Hyppönen E, Läärä E, Reunanen A, Järvelin MR, Virtanen SM. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet. 2001;358(9292):1500–3.CrossRefPubMed
  • 31. Stene LC, Joner G. Norwegian Childhood Diabetes Study Group. Use of cod liver oil during the first year of life is associated with lower risk of childhood-onset type 1 diabetes: a large, population-based, case–control study. Am J Clin Nutr. 2003;78(6):1128–34.PubMed
  • 32. Scragg R, Holdaway I, Singh V, Metcalf P, Baker J, Dryson E. Serum 25-hydroxyvitamin D3 levels decreased in impaired glucose tolerance and diabetes mellitus. Diabetes Res Clin Pract. 1995;27(3):181–8.CrossRefPubMed
  • 33. Chiu KC, Chu A, Go VL, Saad MF. Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr. 2004;79(5):820–5.PubMed
  • 34. Ford ES, Ajani UA, McGuire LC, Liu S. Concentrations of serum vitamin D and the metabolic syndrome among U.S. adults. Diabetes Care. 2005;28(5):1228–30.CrossRefPubMed
  • 35. Borissova AM, Tankova T, Kirilov G, Dakovska L, Kovacheva R. The effect of vitamin D3 on insulin secretion and peripheral insulin sensitivity in type 2 diabetic patients. Int J Clin Pract. 2003;57(4):258–61.PubMed
  • 36. Kumar S, Davies M, Zakaria Y, Mawer EB, Gordon C, Olukoga AO, Boulton AJ. Improvement in glucose tolerance and beta-cell function in a patient with vitamin D deficiency during treatment with vitamin D. Postgrad Med J. 1994;70(824):440–3.CrossRefPubMedPubMedCentral
  • 37. Pittas AG, Dawson-Hughes B, Li T, Van Dam RM, Willett WC, Manson JE, Hu FB. Vitamin D and calcium intake in relation to type 2 diabetes in women. Diabetes Care. 2006;29(3):650–6.CrossRefPubMed
  • 38. Tseng CL, Brimacombe M, Xie M, Rajan M, Wang H, Kolassa J, Crystal S, Chen TC, Pogach L, Safford M. Seasonal patterns in monthly hemoglobin A1c values. Am J Epidemiol. 2005;161(6):565–74.CrossRefPubMed
  • 39. Lindqvist PG, Olsson H, Landin-Olsson M. Are active sun exposure habits related to lowering risk of type 2 diabetes mellitus in women, a prospective cohort study? Diabetes Res Clin Pract. 2010;90(1):109–14.CrossRefPubMed
  • 40. Pittas AG, Lau J, Hu FB, Dawson-Hughes B. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab. 2007;92(6):2017–29.CrossRefPubMedPubMedCentral
  • 41. Hyppönen E, Power C. Vitamin D status and glucose homeostasis in the 1958 British birth cohort: the role of obesity. Diabetes Care. 2006;29(10):2244–6.CrossRefPubMed
  • 42. Scragg R, Sowers M, Bell C. Third National Health and Nutrition Examination Survey. Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey. Diabetes Care. 2004;27(12):2813–8.CrossRefPubMed
  • 43. Pittas AG, Sun Q, Manson JE, Dawson-Hughes B, Hu FB. Plasma 25-hydroxyvitamin D concentration and risk of incident type 2 diabetes in women. Diabetes Care. 2010;33(9):2021.CrossRefPubMedPubMedCentral
  • 44. Robinson JG, Manson JE, Larson J, Liu S, Song Y, Howard BV, Phillips L, Shikany JM, Allison M, Curb JD, Johnson KC, Watts N. Lack of association between 25(OH)D levels and incident type 2 diabetes in older women. Diabetes Care. 2011;34(3):628–34.CrossRefPubMedPubMedCentral
  • 45. Grimnes G, Emaus N, Joakimsen RM, Figenschau Y, Jenssen T, Njølstad I, Schirmer H, Jorde R. Baseline serum 25-hydroxyvitamin D concentrations in the Tromsø Study 1994–95 and risk of developing type 2 diabetes mellitus during 11 years of follow-up. Diabet Med. 2010;27(10):1107–15.CrossRefPubMed
  • 46. Pilz S, van den Hurk K, Nijpels G, Stehouwer CD, Van’t Riet E, Kienreich K, Tomaschitz A, Dekker JM. Vitamin D status, incident diabetes and prospective changes in glucose metabolism in older subjects: the Hoorn study. Nutr Metab Cardiovasc Dis. 2012;22(10):883–9.CrossRefPubMed
  • 47. Dobnig H, Pilz S, Scharnagl H, Renner W, Seelhorst U, Wellnitz B, Kinkeldei J, Boehm BO, Weihrauch G, Maerz W. Independent association of low serum 25-hydroxyvitamin d and 1,25-dihydroxyvitamin d levels with all-cause and cardiovascular mortality. Arch Intern Med. 2008;168(12):1340–9.CrossRefPubMed
  • 48. Lu L, Yu Z, Pan A, Hu FB, Franco OH, Li H, Li X, Yang X, Chen Y, Lin X. Plasma 25-hydroxyvitamin D concentration and metabolic syndrome among middle-aged and elderly Chinese individuals. Diabetes Care. 2009;32(7):1278–83.CrossRefPubMedPubMedCentral
  • 49. Wang TJ, Pencina MJ, Booth SL, Jacques PF, Ingelsson E, Lanier K, Benjamin EJ, D’Agostino RB, Wolf M, Vasan RS. Vitamin D deficiency and risk of cardiovascular disease. Circulation. 2008;117(4):503–11.CrossRefPubMed
  • 50. Zoppini G, Galletti A, Targher G, Brangani C, Pichiri I, Trombetta M, Negri C, De Santi F, Stoico V, Cacciatori V, Bonora E. Lower levels of 25-hydroxyvitamin D3 are associated with a higher prevalence of microvascular complications in patients with type 2 diabetes. BMJ Open Diabetes Res Care. 2015;3(1), e000058.CrossRefPubMedPubMedCentral
  • 51. Arnold DL, Enquobahrie DA, Qiu C, Huang J, Grote N, VanderStoep A, Williams MA. Early pregnancy maternal vitamin D concentrations and risk of gestational diabetes mellitus. Paediatr Perinat Epidemiol. 2015;29(3):200–10.CrossRefPubMedPubMedCentral
  • 52. Gagnon C, Lu ZX, Magliano DJ, Dunstan DW, Shaw JE, Zimmet PZ, Sikaris K, Ebeling PR, Daly RM. Low serum 25-hydroxyvitamin D is associated with increased risk of the development of the metabolic syndrome at five years: results from a national, population-based prospective study (The Australian Diabetes, Obesity and Lifestyle Study: AusDiab). J Clin Endocrinol Metab. 2012;97(6):1953–61.CrossRefPubMed
  • 53. Deleskog A, Hilding A, Brismar K, Hamsten A, Efendic S, Östenson CG. Low serum 25-hydroxyvitamin D level predicts progression to type 2 diabetes in individuals with prediabetes but not with normal glucose tolerance. Diabetologia. 2012;55(6):1668–78.CrossRefPubMed
  • 54. Holick MF. The diabetes and death defining vitamin D. Nat Rev Endocrinol. 2012;8:388–90.CrossRefPubMed
  • 55. Mitri J, Nelson J, Ruthazer R, Garganta C, Nathan DM, Hu FB, Dawson-Hughes B, Pittas AG. Diabetes Prevention Program Research Group. Plasma 25-hydroxyvitamin D and risk of metabolic syndrome: an ancillary analysis in the Diabetes Prevention Program. Eur J Clin Nutr. 2014;68(3):376–83.CrossRefPubMedPubMedCentral
  • 56. Chacko SA, Song Y, Manson JE, Van Horn L, Eaton C, Martin LW, McTiernan A, Curb JD, Wylie-Rosett J, Phillips LS, Plodkowski RA, Liu S. Serum 25-hydroxyvitamin D concentrations in relation to cardiometabolic risk factors and metabolic syndrome in postmenopausal women. Am J Clin Nutr. 2011;94(1):209–17.CrossRefPubMedPubMedCentral
  • 57. Boonchaya-anant P, Holick MF, Apovian CM. Serum 25-hydroxyvitamin D levels and metabolic health status in extremely obese individuals. Obesity (Silver Spring). 2014;22(12):2539–43.
  • 58 Ekwaru JP, Zwicker JD, Holick MF, Giovannucci E, Veugelers PJ. The importance of body weight for the dose response relationship of oral vitamin D supplementation and serum 25-hydroxyvitamin D in healthy volunteers. PLoS One. 2014;9(11), e111265.CrossRefPubMedPubMedCentral
  • 59. Pietras SM, Obayan BK, Cai MH, Holick MF. Vitamin D2 treatment for vitamin D deficiency and insufficiency for up to 6 years. Arch Intern Med. 2009;169(19):1806–8.CrossRefPubMed
  • 60. Biancuzzo RM, Clarke N, Reitz RE, Travison TG, Holick MF. Serum concentrations of 1,25-dihydroxyvitamin D2 and 1,25-dihydroxyvitamin D3 in response to vitamin D2 and Vitamin D3 supplementation. J Clin Endocrinol Metab. 2013;98(3):973–9.CrossRefPubMedPubMedCentral
  • 61. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes. Estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27(5):1047–53.CrossRefPubMed
  • 62. Takiishi R, Gysemans C, Bouillon R, Mathieu C. Vitamin D and diabetes. Endocrinol Metab Clin North Am. 2010;39:419–46.CrossRefPubMed


Created by admin. Last Modification: Sunday July 16, 2017 10:27:49 GMT-0000 by admin. (Version 4)