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Role of Vitamin D in the Pathogenesis of Diabetes – Holick July 2017

Principles of Diabetes Mellitus, pp 107-119, 08 July 2017
Nadine E. Palermo , Michael F. Holick

See also VitaminDWiki

Search VitaminDWiki for HOLICK DIABETES 1860 items as of July 2017

Overview Diabetes and vitamin D contains this summary]

  • Diabetes is 5X more frequent far from the equator
  • Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
  • Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
  • Sedentary people get less sun / Vitamin D
  • Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
  • Elderly get 4X less vitamin D from the same amount of sun
        Elderly also spend less time outdoors and have more clothes on
  • All items in category Diabetes and Vitamin D 529 items: both Type 1 and Type 2

Vitamin D appears to both prevent and treat diabetes

Number of articles in both categories of Diabetes and:
'This list is automatically updated''

  • Dark Skin 24;   Intervention 56;   Meta-analysis 38;   Obesity 34;  Pregnancy 43;   T1 (child) 39;  Omega-3 11;  Vitamin D Receptor 23;  Genetics 12;  Magnesium 27    Click here to see details

Some Diabetes studies

50 ng of Vitamin D fights Diabetes

T1 Diabetes


Diabetes, Metabolic Syndrome and Magnesium - many studies

Pages listed in BOTH of the categories Diabetes and Intervention

Pages listed in BOTH of the categories Diabetes and Meta-analysis

With the predicted continued rise in patients diagnosed with diabetes and anticipated progressive loss of beta cell function in those already affected, there has been ongoing interest in understanding the mechanism of pathogenesis as well as identifying factors that may modulate dysglycemia.
Several observational and interventional studies have sought to demonstrate improvement in glycemic control and insulin sensitivity based on vitamin D status.
While this relationship has not been consistently seen in medical literature, is it likely due to the

  • duration of intervention,
  • dose and underlying vitamin D status

as the most pronounced effect of vitamin D supplementation on glycemic control has been observed in patients with vitamin D deficiency/insufficiency and who do not have established diabetes.

Evidence suggests that vitamin D’s effect on the immune system may play a role in reducing risk for developing type 1 diabetes. Therefore, improvement in vitamin D status throughout life may help reduce risk for developing both type 1 and type 2 diabetes as well as improve glycemic control in those who have these disorders.


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