Toggle Health Problems and D

Gestational Diabetes 39 percent more likely if insufficient Vitamin D – Meta-analysis March 2018

Maternal Vitamin D Status and Risk of Gestational Diabetes: a Meta-Analysis.

Cell Physiol Biochem. 2018;45(1):291-300. doi: 10.1159/000486810. Epub 2018 Jan 19.
Hu L1,2, Zhang Y3, Wang X2, You L2, Xu P2, Cui X2, Zhu L2, Ji C2, Guo X2, Wen J2.

 Download the PDF from VitaminDWiki

Whether maternal vitamin D deficiency is associated with gestational diabetes remains controversial. This meta-analysis aimed to systematically evaluate published evidence on the association between maternal vitamin D status and the risk of gestational diabetes.

We retrieved relevant articles from the PubMed, Medline and Embase databases up to May 2017 for observational studies investigating the association between vitamin D status and the risk of gestational diabetes. Odds ratios (OR) or risk ratios (RR) from individual studies were pooled using the fixed and random effect models.

The meta-analysis of 29 observational studies included 28,982 participants, of which 4,634 were diagnosed with gestational diabetes, and showed that

  • maternal vitamin D insufficiency was associated with a significantly increased risk of gestational diabetes by 39% (pooled OR = 1.39, 95%CI = 1.20-1.60) with moderate heterogeneity (I2 = 50.2%; P = 0.001).

Moreover, the 25(OH)D level was significantly lower in gestational diabetes cases than in controls with a pooled effect of -4.79 nmol/L (95% CI = -6.43, -3.15). Significant heterogeneity was also detected (I2 = 65.0%, P < 0.001). Further subgroup analysis indicated that this association was also evident in most subpopulations.

This meta-analysis indicated a significant association between vitamin D insufficiency and increased risk of gestational diabetes. Further well-designed large-scale clinical trials are essential to verify this association.

PMID: 29402818 DOI: 10.1159/000486810

Created by admin. Last Modification: Saturday March 23, 2019 11:11:50 GMT-0000 by admin. (Version 4)

Attached files

ID Name Comment Uploaded Size Downloads
9537 GD Meta.jpg admin 17 Mar, 2018 51.64 Kb 529
9536 Gestational Diabete - a Meta-Analysis.pdf admin 17 Mar, 2018 1.40 Mb 594