Vitamin-D supplementation in prediabetes reduced progression to type 2 diabetes and was associated with decreased insulin resistance and systemic inflammation: An open label randomized prospective study from Eastern India
Diabetes Research and Clinical Practice
Deep Dutta , Samim Ali Mondal , Subhadip Choudhuri , Indira Maisnam , Abu Hena Hasanoor Reza , Basudeb Bhattacharya , Subhankar Chowdhury , Satinath Mukhopadhyay
Vitamin-D supplementation in vitamin-D insufficient/deficient prediabetes individuals is associated with significantly lower progression to diabetes (6/55 vs. 13/49; p=0.04) and higher reversal to normoglycemia (23/55 vs. 10/49; p=0.02), associated with decreased insulin resistance and systemic inflammation (TNFα and IL6). Baseline vitamin-D and 2h blood glucose independently predicted progression to diabetes.