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Vitamin D reduced only the systolic blood pressure in T2DM – Meta-analysis April 2019

Vitamin D ameliorates systolic but not diastolic blood pressure in patients with type 2 diabetes: Results from a meta-analysis of randomized controlled trials.

Int J Vitam Nutr Res. 2019 Apr 30:1-10. doi: 10.1024/0300-9831/a000291
Jafari T1,2, Fallah AA3, Rostampour N4, Mahmoodnia L5.


Items in both categories Hypertension and Meta-analyses are listed here:

Items in both categories Hypertension and Diabetes are listed here:

Inconsistent findings have been reported regarding the effects of vitamin D on blood pressure in patients with type 2 diabetes (T2D). This study aimed to evaluate the subject through a meta-analysis. A computerized literature search on five databases was performed and randomized controlled trials (RCTs) published until March 2016 were identified. The eligibility criteria for articles to be selected were parallel-group RCTs in which consumption of a kind of vitamin D was compared with placebo in patients with T2D. Un-standardized mean difference and its corresponding 95 % confidence interval (CI) was calculated from the effect sizes by using random effects model. Studies comparing intervention group (received vitamin D) with control group (received placebo) were enrolled in meta-analysis.
Meta-analysis on 26 studies with 1789 type 2 diabetic subjects showed that vitamin D significantly

  • reduced systolic blood pressure (SBP; -0.97 mmHg, 95 % CI: -1.94, -0.001, P = 0.050), but
  • not diastolic blood pressure (DBP; -0.10 mmHg, 95 % CI: -0.22, 0.02, P = 0.087).

Subgroup analyses showed that administration of vitamin D in patients with baseline serum 25-hydroxyvitamin D < 50 nmol/l and baseline SBP < 140 mmHg significantly reduced SBP. Moreover, the patients who received vitamin D without Ca co-supplementation showed significant reduction in SBP. Vitamin D doses (< 2000 or > 2000 IU/ day) and method of vitamin D application (Supplementation or food fortification) did not affect the blood pressure. This study demonstrated that vitamin D improved SBP in type 2 diabetic patients. Therefore, this vitamin can be considered as an adjuvant therapy in these patients.

Created by admin. Last Modification: Wednesday May 15, 2019 11:58:24 GMT-0000 by admin. (Version 4)