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Gestational diabetes – Vitamin D and Calcium provided huge benefits – RCT March 2015

Calcium plus vitamin D supplementation affects pregnancy outcomes in gestational diabetes: randomized, double-blind, placebo-controlled trial.

Public Health Nutr. 2015 Mar 20:1-8. [Epub ahead of print]
Karamali M 1, Asemi Z 2, Ahmadi-Dastjerdi M 1, Esmaillzadeh A 3.
1 Department of Gynecology and Obstetrics, School of Medicine, Arak University of Medical Sciences, Arak, Islamic Republic of Iran.
2 Department of Nutrition, Research Center for Biochemistry and Nutrition in Metabolic Diseases,Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran.
3 Food Security Research Center,Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran.

VitaminDWiki Summary and references

60 women with GDM in Iran – randomized half of them supplementing with
50,000 IU vitamin D twice – at day 1 and day 21
1 gram of Calcium daily for 6 weeks

Vitamin D No D
Caesarean section rate 23 % 63 %
Maternal hospitalization 0 %13 %
Infant Macrosomia
(Large for gestational age)
0 % 13 %
Infant hyperbilirubinaemia30 %57 % 

Notes by VitaminDWiki

  1. ~2400 IU daily for Iranian women (who are typically very vitamin D deficient)
  2. Some of the women will probably have had high BMI
  3. Vitamin D dose needed for high BMI is 2-3 more than for normal BMI ((dose did not vary with weight in this study)
  4. Unsure if the Calcium is needed

See also VitaminDWiki

See also web
Increasing Prevalence of Gestational Diabetes and Pregnancy-Related Hypertension in Los Angeles County, California, 1991–2003

Gestational diabetes (top of chart = 1%)

Racial/Ethnic Differences in the Percentage of Gestational Diabetes Mellitus Cases Attributable to Overweight and Obesity, Florida, 2004-2007

Gestational Diabetes Risk Factors Mayo Clinic
Age greater than 25, Family or personal health history,BMI> 30, Nonwhite race
WebMD adds the following factors
Previously giving birth to a baby over 9 pounds, given birth to a stillborn baby, previously had gestational diabetes

The present study was designed to assess the effects of Ca+vitamin D supplementation on pregnancy outcomes in women with gestational diabetes mellitus (GDM).

A randomized, double-blind, placebo-controlled trial was conducted among sixty women with GDM. Participants were divided into two groups to receive Ca+vitamin D supplements or placebo. Individuals in the Ca+vitamin D group (n 30) received 1000 mg Ca/d and two pearls containing 1250 µg (50 000 IU) of cholecalciferol (vitamin D3) during the intervention (one at study baseline and another at day 21 of the intervention); those in the placebo group (n 30) received two placebos of vitamin D at the mentioned times and placebos of Ca every day for 6 weeks. Pregnancy outcomes were determined.

A urban community setting in Arak, Iran.

Sixty women with GDM and their newborns, living in Arak, Iran were enrolled.

Women treated with Ca+vitamin D had a significant decrease in caesarean section rate (23·3 % v. 63·3 %, P=0·002) and maternal hospitalization (0 v. 13·3 %, P=0·03) compared with those receiving placebo. In addition, newborns of GDM women randomized to Ca+vitamin D had no case of macrosomia, while the prevalence of macrosomia among those randomized to placebo was 13·3 % (P=0·03). Lower rates of hyperbilirubinaemia (20·0 % v. 56·7 %, P=0·03) and hospitalization (20·0 % v. 56·7 %, P=0·03) were also seen in the supplemented group of newborns than in the placebo group.

Ca+vitamin D supplementation for 6 weeks among pregnant women with GDM led to decreased caesarean section rate and maternal hospitalization, and decreased macrosomia, hyperbilirubinaemia and hospitalization in newborns.

PMID: 25790761

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VitaminDWiki pages listed in BOTH the categories Diabetes and Pregnancy

Attached files

ID Name Comment Uploaded Size Downloads
5202 GDM vs BMI.jpg admin 21 Mar, 2015 29.01 Kb 2164
5201 GDM rate.jpg admin 21 Mar, 2015 32.73 Kb 3452