The effect of vitamin D supplementation on gestational diabetes in high-risk women: Results from a randomized placebo-controlled trial - 2016
J Res Med Sci. 2016 Jan 28;21:2. eCollection 2016.
Shahgheibi S1, Farhadifar F1, Pouya B1.
1Department of Obstetrics and Gynecology, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Pages listed in BOTH the categories Diabetes and Pregnancy
- Gestational Diabetes 2.4X more likely if poor Vitamin D Receptor (region in China) – June 2019
- Vitamin D food fortification during pregnancy reduced gestational diabetes in daughters by 13 percent – Nov 2018
- Gestational Diabetes 3 X more likely if poor Vitamin D receptor (Turkey) – May 2019
- Type 1 Diabetes risk increased if high postpartum Vitamin D binding protein – Jan 2019
- Vitamin D treats Gestational Diabetes, decreases hospitalization and newborn complications – meta-analysis March 2019
- Maternal Diabetes and Risk of Autism in Offspring – JAMA June 2018
- Gestational Diabetes 39 percent more likely if insufficient Vitamin D – Meta-analysis March 2018
- Gestational Diabetes 1.9 X more likely if low vitamin D – review Dec 2017
- Congenital Heart Disease is associated with gestational diabetes in first trimester (need Vitamin D and Omega-3 early) Dec 2017
- Gestational Diabetes Mellitus associated with 4 Vitamin D genes – Oct 2015
- Gestational diabetes 30 percent less likely if consumed more than 400 IU of vitamin D daily – Oct 2017
- Low vitamin D plus gestational diabetes resulted in increased ICU use, SGA – Oct 2016
- Gestational diabetes treated by Vitamin D plus Omega-3 – RCT Feb 2017
- Gestational Diabetes reduce 3 times by 5,000 IU of Vitamin D – RCT Jan 2016
- Gestational Diabetes treated with 50,000 IU every two weeks – RCT Sept 2016
- Low vitamin D in pregnancy – epigenetic pancreas problems in offspring (mice) – May 2016
- MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015
- Gestational Diabetes 3.7 X more likely if smoke and have low vitamin D (no surprise) – Feb 2016
- Gestational Diabetes helped by Vitamin D and Calcium (also less C-section and LGA) – RCT Jan 2016
- Diabetes in child not prevented by a tiny amount of vitamin D during pregnancy – Nov 2015
- Gestational Diabetes Mellitus 1.5X more likely if low vitamin D – meta-analysis Oct 2015
- Gestational Diabetes increasing, especially in dark skinned women (low vitamin D) - 2007
- Increased Gestational Diabetes and poorer infant health associated with low vitamin D – June 2015
- Gestational Diabetes in 10 percent of pregnancies, vitamin D probably helps – Jan 2014
- Gestational diabetes – Vitamin D and Calcium provided huge benefits – RCT March 2015
- Gestational diabetes reduced by just two 50,000 IU doses of vitamin D – RCT Nov 2014
- Gestational Diabetes reduced with 50,000 IU of vitamin D every 3 weeks and daily Calcium – RCT June 2014
- Gestational Diabetes reduced 40 percent by 5,000 IU of vitamin D – RCT April 2014
- Insulin resistance during pregnancy improved with 50,000 IU of vitamin D every 2 weeks – RCT April 2013
- During pregnancy even 400 IU helps metabolic status – RCT July 2013
- Will 1600 IU vitamin D prevent gestational diabetes – no, not enough, July 2013
- Vitamin D protects against many types of health problems – review May 2013
- Dr. Holick video on vitamin D - March 2013
- Gestational diabetes 2.2X more likely below 10 ng of vitamin D – June 2012
- Gestational diabetes 60 percent more likely below 20 ng of vitamin D – meta-analysis Feb 2012
- Type I diabetes 2X more likely if mother had low vitamin D – Jan 2012
- 300,000 IU injection loading dose of vitamin D3 stopped gestational diabetes in RCT – Oct 2011
- Less muscle and insulin resistance for children of vitamin D deficient mothers – Jan 2011
- Vitamin D Levels at Birth May Predict Obesity Risk at age 3 - Oct 2010
Vitamin D deficiency is common in pregnancy, leading to increase in the frequency of preeclampsia, cesarean delivery, neonatal bacterial vaginosis, and gestational diabetes. The current study was designed and implemented to investigate the effect of vitamin D during the first and second trimesters of pregnancy in reducing the risk of gestational diabetes mellitus (GDM) in women who are at high risk [history of GDM, birth macrosomia, family history, and high body mass index (BMI)].
MATERIALS AND METHODS:
In a randomized, double-blind, and placebo-controlled trial, 90 pregnant women who had at least one risk factor for GDM were randomized into intervention (46 participants) and control (44 participants) groups. Participants in the intervention group took 5000 units of vitamin D daily and the control group took placebo until the 26th week of pregnancy. Then the glucose challenge test (GCT) and the glucose tolerance test (GTT) were performed to evaluate GDM.
Mean ± standard deviation (SD) age was 31.28 ± 6.38 years and 29 ± 6.24 years for the intervention group and the placebo group, respectively, (P > 0.05). In addition, there were no significant differences between two groups in terms of vitamin D levels and GCT (P > 0.05), and the difference was not significant. The incidence of diabetes in the intervention groups was statistically lower than in control group (11.4% vs 34.8; P < 0.01). The results showed that abnormal GCT in the placebo group was statistically higher than in intervention group (35.9% vs 10.9 P < 0.005).
The results of the current study showed that the prescription of vitamin D supplementation in the first and second trimesters of pregnancy was effective in reducing GDM and controlling GTT and GTC.
The effects of vitamin D and probiotic co-supplementation on glucose homeostasis, inflammation, oxidative stress and pregnancy outcomes in gestational diabetes: A randomized, double-blind, placebo-controlled trial
Clinical Nutrition, https://doi.org/10.1016/j.clnu.2018.10.028
Background and aims This study was designed to assess the effects of combined vitamin D and probiotic supplementation on metabolic status and pregnancy outcomes in women with gestational diabetes (GDM).
Methods: This randomized, double-blind, placebo-controlled clinical trial was performed in 87 women with GDM. Patients were randomly assigned three groups to receive either vitamin D (50,000 IU/every 2 weeks) plus probiotic (8×109 CFU/day) (n=30), probiotic (8×109 CFU/day) (n=29) or placebo (n=28) for 6 weeks.
Results: Vitamin D and probiotic co-supplementation significantly reduced
- fasting plasma glucose (β -10.99 mg/dL; 95% CI, -14.26, -7.73; P<0.001),
- serum insulin levels (β -1.95 μIU/mL; 95% CI, -3.05, -0.84; P=0.001) and
- homeostasis model of assessment-insulin resistance (β -0.76; 95% CI, -1.06, -0.45; P<0.001), and
- the quantitative insulin sensitivity check index (β 0.01; 95% CI, 0.008, 0.03; P=0.001) compared with the placebo.
In addition, vitamin D and probiotic co-supplementation resulted in a
- significant reduction in triglycerides (β -37.56 mg/dL; 95% CI, -51.55, -23.56; P<0.001),
- VLDL- (β -7.51 mg/dL; 95% CI, -10.31, -4.71; P<0.001),
- HDL-/total cholesterol ratio (β -0.52; 95% CI, -0.79, -0.24; P<0.001),
- high sensitivity C-reactive protein (β -1.80 mg/L; 95% CI, -2.53, -1.08; P<0.001) and
- malondialdehyde (β -0.43 μmol/L; 95% CI, -0.77, -0.09; P=0.01);
also, a significant rise in
- HDL-cholesterol (β 4.09 mg/dL; 95% CI, 1.11, 7.08; P=0.008) and
- total antioxidant capacity (TAC) levels (β 97.77 mmol/L; 95% CI, 52.34, 143.19; P<0.001) were observed compared with the placebo.
Vitamin D and probiotic co-supplementation did not change other metabolic parameters.
Vitamin D and probiotic co-supplementation significantly decreased triglycerides (P=0.02), VLDL-cholesterol (P=0.02) and hs-CRP (P=0.01), and significantly increased TAC (P=0.006) and total glutathione levels (P=0.04) compared with only probiotic group.
Conclusions: In conclusion, vitamin D and probiotic co-supplementation in women with GDM had beneficial effects on metabolic status.