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Several Diabetic pains reduced by injection of 300,000 IU of Vitamin D – RCT Feb 2020

Does Vitamin D Affect Diabetic Neuropathic Pain and Balance?

J Pain Res, 13, 171-179 2020 Jan 16 eCollection 2020. DOI: 10.2147/JPR.S203176
Aylin Sari 1, Zeynep Akdoğan Altun 1, Cigdem Arifoglu Karaman 1, Basak Bilir Kaya 1, Bekir Durmus 2

VitaminDWiki

Injection of 300,000 IU decreased several pain measures 12 weeks later

Poor guts need different forms of vitamin D - or injection

Guesses of Vitamin D response if poor gut

Bio FormSpeedDuration
10Injection ($$$)
or Calcidiol or Calcitriol
D - Slow
C -Fast
Long
10 Sun/UVBSlowLong
10Topical
(skin patch/cream, vagina)
Slow
Fast nano
Normal
9Nanoemulsion -mucosal
perhaps activates VDR
FastNormal
9?Inhaled (future)FastNormal
8Bio-D-Mulsion ForteNormalNormal
6Water soluble (Bio-Tech)NormalNormal
4Sublingual/spray
(some goes into gut)
FastNormal
3Coconut oil basedSlowNormal
2Food (salmon etc.)SlowNormal
2Olive oil based (majority)SlowNormal

10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 months


Injection contains the following

{SQL(db=>vitamind)}SELECT COUNT(*) FROM `tiki_category_objects` WHERE `categId`=165{SQL} items in Vitamin D Injection category

{BOX(title="Did you know?" class="border" bg=>#FF9,width= "700px")}

{img src="display2696" link="Getting Vitamin D into your body"}

  • Injections are currently made by medical professionals into muscle
  • Home injection of Vitamin D appears to be possible in the future
  • Injections are useful for people who might forget to take their periodic supplement (children, elderly, etc) and those who cannot swallow or have poor digestion
  • While Vitamin D2 is historically the common form, Vitamin D3 is far better
  • Should check (if there is time) for possible allergic reaction to Vitamin D or lack of Magnesium for both for loading dose and injection
  • Note 600,000 IU Vitamin D loading dose via capsules is 1/20th the cost($2.40) of an injection, and does not require a prescription
  • 100,000 IU single dose of vitamin D - 2010 has the following
    {img type="attId" attId="5984" width="400"}
  • Vitamin D injection lasts longer and has bigger response than weekly oral – Jan 2017 has the following
    {img type="attId" attId="7560" width="400"}

Pain - chronic category has the following

137 items in category Chronic pain

See also


Overview Diabetes and vitamin D contains the following

  • Diabetes is 5X more frequent far from the equator
  • Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
  • Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
  • Sedentary people get less sun / Vitamin D
  • Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
  • Elderly get 4X less vitamin D from the same amount of sun
        Elderly also spend less time outdoors and have more clothes on
  • All items in category Diabetes and Vitamin D 453 items: both Type 1 and Type 2

Vitamin D appears to both prevent and treat diabetes

  • Appears that >2,000 IU will Prevent
  • Appears that >4,000 IU will Treat , but not cure
  • Appears that Calcium and Magnesium are needed for both Prevention and Treatment
    • which are just some of the vitamin D cofactors

Number of articles in both categories of Diabetes and:

  • Dark Skin 22;   Intervention 49;   Meta-analysis 28;   Obesity 26;  Pregnancy 39;   T1 (child) 34;  Omega-3 10;  Vitamin D Receptor 18;  Genetics 10;  Magnesium 18    Click here to see details

Diabetic Epidemic

  • Step back to 1994. Suppose an epidemic struck the United States, causing blindness, kidney failure, and leg amputations in steadily increasing numbers.
    Suppose that in less than a decade's time, the epidemic had victimized one out of every eight people
    That epidemic is real, and its name is diabetes, now the nation's sixth leading cause of death.
    Chart from the web (2018?)
    Image

 Download the PDF from VitaminDWiki
Image

Purpose: This randomized, placebo-controlled study examined the effect of vitamin D replacement therapy on neuropathic symptoms and balance in patients with diabetic neuropathic pain and low vitamin D levels.

Patients and methods: Among the 258 patients, the results in a total of 57 volunteers (32 in the treatment and 25 in the control arm) meeting the inclusion criteria are reported. Symptoms of neuropathic pain were assessed using Douleur Neuropathique 4 (DN4) questionnaire, and presence of polyneuropathy (PNP) was determined by performing electromyography (EMG). Balance was assessed using Berg balance test (BBT). After undergoing these examinations, the patients in the treatment group were intramuscularly (IM) injected with 300,000 IU vitamin D in a liquid formulation and those in the placebo group were IM injected with physiological saline. The DN4 and BBT were repeated after 12 weeks, and the results were compared.

Results: The patients in the treatment group showed a significant decrease in total DN4 scores from baseline to the study endpoint compared with the patients in the placebo group (p=0.008). The patients in the treatment group also showed a significant increase in BBT scores from baseline to the study endpoint compared with the patients in the placebo group (p=0.001). Furthermore, in subgroup analysis, these patients showed a significant decrease in electric shock and burning sensation scores from baseline to the study endpoint compared with the patients in the placebo group (p=0.006, p=0.001, respectively).

Conclusion: In patients with diabetic neuropathic pain, vitamin D levels should be measured and vitamin D replacement therapy should be administered as required to resolve neuropathic symptoms and to improve balance.

Attached files

ID Name Comment Uploaded Size Downloads
13490 Pain 300,000.jpg admin 13 Feb, 2020 17:49 138.22 Kb 206
13489 300,000 IU injection Diabetic Neuropathic Pain.pdf PDF 2020 admin 13 Feb, 2020 17:49 2.53 Mb 122
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