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Gestational diabetes reduced by just two 50,000 IU doses of vitamin D – RCT Nov 2014

Favorable Effects of Vitamin D Supplementation on Pregnancy Outcomes in Gestational

Horm Metab Res. 2014 Nov 5. [Epub ahead of print]
Diabetes: A Double Blind Randomized Controlled Clinical Trial.
Asemi Z1, Karamali M2, Esmaillzadeh A3.

VitaminDWiki Summary

50,000 IU capsules: first about week 26 and second about week 29

Vitamin DPlacebo
(excessive amniotic fluid)
0% 17%
27 % 61%

Gestational diabetes mellitus (GDM) has been recognized as a significant risk factor for unfavorable pregnancy outcomes. Prevalence of vitamin D deficiency is highly prevalent among women with GDM. This study was designed to assess the effect of vitamin D supplementation on pregnancy outcomes of pregnant women with GDM who were not on oral hypoglycemic agents. This randomized controlled clinical trial was performed among 45 pregnant women diagnosed with GDM at 24-28 weeks' gestation.

Subjects were randomly assigned to consume either vitamin D supplements (cholecalciferol) or placebo. Individuals in the vitamin D group (n=22) received 50 000 IU vitamin D3 pearl 2 times during the study: at study baseline and day 21 of intervention and those in placebo group (n=23) received 2 placebos at the mentioned times. Fasting blood samples were taken at baseline to measure fasting plasma glucose. Participants underwent a 3-h oral glucose tolerance tests (OGTT) and the blood samples were collected at time 60, 120, and 180 min to measure plasma glucose levels. Newborn's weight, height, head circumference, Apgar score, and hyperbilirubinemia were determined. Taking vitamin D supplements, compared with placebo, resulted in improved pregnancy outcomes; such that those in the vitamin D group had no case of polyhydramnios, while 17.4% of subjects in placebo group had this condition (p=0.04). In addition, newborn's hyperbilirubinemia was significantly lower in vitamin D group than that in placebo group (27.3% vs. 60.9%, p=0.02).

In conclusion, vitamin D supplementation for 6 weeks among pregnant women with GDM resulted in decreased maternal polyhydramnios and infant hyperbilirubinemia compared with placebo. Clinical trial registration number www.irct.ir:IRCT201305115623N7.

© Georg Thieme Verlag KG Stuttgart · New York.
Publisher sells PDF for $36

PMID: 25372774

See also VitaminDWiki

Vitamin D No D
Caesarean section rate (23 % 63 %
Maternal hospitalization 0 %13 %
Infant Macrosomia
Large for gestational age
0 % 13 %
Infant hyperbilirubinaemia30 %57 %

Pages listed in BOTH the categories Diabetes and Pregnancy

See also web

  • Vitamin D status and gestational diabetes mellitus Sept 2015
    8 doses of 50,000 IU did not help GDM (which had been 25 ng vs 46 ng for controls) to those who were < 20 ng
    Did not indicate the vitamin D levels after intervention
    Did not indicate how many no-respoders or non-responders