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Diabetic Retinopathy 27 percent more likely if low vitamin D – meta-analysis May 2016

Retinopathy Linked to Vitamin D Deficiency MedPageToday – with CME

  • “In a meta-analysis that included 11 publications and involved studies that included about 6,000 individuals, diabetic patients with vitamin D deficiency were 26.7% more likely to have diabetic retinopathy than patients who were not deficient in the so-called sunshine vitamin (OR 1.267 [95% CI 1.168-1.373, P<0.001]), said Anawin Sanguankeo, MD, a resident in medicine at Bassett Medical Center, Cooperstown, N.Y.”
  • . . “annual meeting of the American Association of Clinical Endocrinologists”
  • “. . .mean difference of -2.25 ng/mL (95% CI: -3.64 to -0.87, P=0.001),”
  • . . “vitamin D deficiency was defined as a serum level less than 20 ng/mL; optimal vitamin D level was defined as a serum level greater than 30 ng/mL.”

 Download the Abstract from VitaminDWiki Publisher wants $36 for the PDF http://dx.doi.org/10.1016/j.jcjo.2016.10.004

Meta-analysis published in 2017 - same 27%, probably the same meta-analysis

__Relationship between vitamin D deficiency and diabetic retinopathy: a meta-analysis
Jason Zhang, MD, Sikarin Upala, MD, MS'Correspondence information about the author MD, MS Sikarin UpalaEmail the author MD, MS Sikarin Upala, Anawin Sanguankeo, MD
DOI: http://dx.doi.org/10.1016/j.jcjo.2016.10.004 |

The purpose of this study was to evaluate the evidence for an association between diabetic retinopathy (DR) and vitamin D deficiency.

Design: Meta-analysis.

Methods: We included 14 observational studies with 10 007 participants who had undergone assessment for both DR and vitamin D deficiency. Pooled odds ratios (ORs) and 95% CIs were calculated using a random-effect, Mantel–Haenszel analysis.

Results: There was a statistically significant association between DR and vitamin D deficiency with an overall pooled OR of 1.27 (95% CI, 1.17–1.37; P = 0.001; I2 = 80%; Pheterogeneity = 0.01). There was also a statistically significant lower serum vitamin D level in patient subgroups with DR versus control groups, with an overall mean difference of –1.32 ng/mL (95% CI, –2.50 to –0.15; P = 0.001; I2 = 89%; Pheterogeneity = 0.01).

Conclusion: There is a statistically significant association between vitamin D deficiency and DR.

Publisher wants $36 for the PDF

See also VitaminDWiki

Diabetic Retinopathy associated with low Vitamin D - many studies
Overview Diabetes and vitamin D contains the following summary

  • Diabetes is 5X more frequent far from the equator
  • Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
  • Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
  • Sedentary people get less sun / Vitamin D
  • Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
  • Elderly get 4X less vitamin D from the same amount of sun
        Elderly also spend less time outdoors and have more clothes on
  • All items in category Diabetes and Vitamin D 543 items: both Type 1 and Type 2

Vitamin D appears to both prevent and treat diabetes

Number of articles in both categories of Diabetes and:
'This list is automatically updated''

  • Dark Skin 24;   Intervention 56;   Meta-analysis 38;   Obesity 35;  Pregnancy 44;   T1 (child) 39;  Omega-3 11;  Vitamin D Receptor 24;  Genetics 13;  Magnesium 29    Click here to see details

Some Diabetes studies

50 ng of Vitamin D fights Diabetes

T1 Diabetes


Diabetes, Metabolic Syndrome and Magnesium - many studies

The items in both Diabetes and Vision are listed here:

Attached files

ID Name Comment Uploaded Size Downloads
6709 Retinopathy meta-analysis.pdf admin 28 May, 2016 235.58 Kb 1150