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Insulin Resistance is associated with low Vitamin D (both diabetic and non-diabetic) – meta-analysis May 2021

Insulin Resistance Is Inversely Associated with the Status of Vitamin D in Both Diabetic and Non-Diabetic Populations

Nutrients 2021, 13(6), 1742; https://doi.org/10.3390/nu13061742
by Shamaila Rafiq *OrcID andPer Bendix JeppesenOrcID
Department of Clinical Medicine, Aarhus University, Aarhus N, 8200 Aarhus, Denmark

Non Diabetic
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Diabetic
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VitaminDWiki

Overview Diabetes and vitamin D contains the following

  • Diabetes is 5X more frequent far from the equator
  • Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
  • Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
  • Sedentary people get less sun / Vitamin D
  • Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
  • Elderly get 4X less vitamin D from the same amount of sun
        Elderly also spend less time outdoors and have more clothes on
  • All items in category Diabetes and Vitamin D 479 items: both Type 1 and Type 2

Vitamin D appears to both prevent and treat diabetes

  • Appears that >2,000 IU will Prevent
  • Appears that >4,000 IU will Treat , but not cure
  • Appears that Calcium and Magnesium are needed for both Prevention and Treatment
    • which are just some of the vitamin D cofactors

Number of articles in both categories of Diabetes and:

  • Dark Skin 23;   Intervention 52;   Meta-analysis 34;   Obesity 28;  Pregnancy 40;   T1 (child) 37;  Omega-3 11;  Vitamin D Receptor 21;  Genetics 11;  Magnesium 19    Click here to see details

VitaminDWili pages containing "insulin" in title

Items found: 32
Title Modified
Insulin Resistance is associated with low Vitamin D (both diabetic and non-diabetic) – meta-analysis May 2021 30 Jun, 2021
Low bone mineral density is inversely associated with both Vitamin D and Resistin (resistance to insulin) 15 Jan, 2021
Excessive insulin decreases vitamin D in 4 ways – problems for diabetic COVID-19 – Dec 2020 12 Dec, 2020
How Vitamin D prevents Insulin Resistance – Sept 2020 17 Sep, 2020
How Vitamin D both prevents and treats insulin resistance (Diabetes) – April 2019 29 Dec, 2019
Pregnancies helped by Vitamin D (insulin and birth weight in this case) – 28th meta-analysis Oct 2019 27 Nov, 2019
Insulin prices and usage are soaring 03 Apr, 2019
Insulin problems reduced by Curcumin if not also take Omega-3 – RCT Jan 2019 01 Feb, 2019
Omega-3 helps muscles and reduces inflammation, lipids, and insulin – Nov 2015 03 Mar, 2018
Off topic: Insulin spike cut in half if take 1 tablespoon of extra virgin olive oil with meal – RCT June 2017 31 May, 2017
CDC confirms association between more vitamin D and less insulin – Jan 2011 31 May, 2017
Insulin resistance 35 percent less likely when vitamin D levels raised by 30 ng – Oct 2015 10 Jun, 2016
Insulin resistance during pregnancy improved with 50,000 IU of vitamin D every 2 weeks – April 2013 23 May, 2016
Insulin resistance during pregnancy improved with 50,000 IU of vitamin D every 2 weeks – RCT April 2013 23 May, 2016
Less muscle and insulin resistance for children of vitamin D deficient mothers – Jan 2011 05 May, 2016
Small for gestational age and insulin at age 6 – Sept 2012 21 Apr, 2016
1 night without sleep affects insulin resistance as much as 6 months of high fat diet (vitamin D not mentioned) – Nov 2015 05 Nov, 2015
Insulin sensitivity in obese adolescents greatly improved with 4000 IU of vitamin D - RCT April 2013 20 Mar, 2013
Insulin improvement in obese teens with 4000 IU of vitamin D – RCT Feb 2013 11 Mar, 2013
Insulin resistance helped with 50000 IU of vitamin D weekly – Feb 2013 11 Mar, 2013
Role of vitamin D in insulin resistance – Sept 2012 17 Jan, 2013
Scientific explanation of vitamin D relationship to insulin resistance– Dec 2012 08 Dec, 2012
8 weeks of 7000 IU vitamin D was not enough for seniors to improve insulin resistance – July 2012 08 Aug, 2012
Vitamin D genes and insulin resistance – MS Aug 2010 02 Jun, 2011
Overview of Vitamin D and Insulin – 2010 04 Feb, 2011
Vitamin D deficiency and insulin insensitivity in African Americans - 2010 05 Nov, 2010
Weight loss improves both vitamin D and insulin resistance – Sept 2010 09 Sep, 2010
Vitamin D reduced insulin resistance – Feb 2010 30 Aug, 2010
4000 IU vitamin D3 improves insulin resistance – Feb 2010 01 Aug, 2010
Vitamin D Improves Insulin Sensitivity and Helps Prevent Diabetes – March 2010 20 Jun, 2010
Insulin resistance correlated with low vitamin D levels in Arab Americans – June 2010 09 Jun, 2010
Insulin sensitivity associated with Vit D in A-A April 2010 13 May, 2010

 Download the PDF from VitaminDWiki

Vitamin D has been implicated in the regulation of glucose metabolism and insulin resistance. We designed this study to provide evidence that insulin resistance is dependent on the concentration of vitamin D in the body. Forty observational studies of both type 2 diabetes mellitus patients and healthy subjects were included in this meta-analysis. Related articles were searched from Embase, PubMed, and Medline through January 2021. Filters for search were used to obtain more focused results. We used Comprehensive Meta-Analysis Version 3 for the construction of forest plots. RevMan software version 5.3 was used to build the risk of bias tables and summary plots. The observational studies included in this systematic review and meta-analysis showed an inverse relationship of insulin resistance with the status of vitamin D both in non-diabetic (r = −0.188; 95% CI = −0.141 to −0.234; p = 0.000) and diabetic (r = −0.255; 95% CI = −0.392 to −0.107, p = 0.001) populations.

From the meta-analysis we concluded that hypovitaminosis D is related to increased levels of insulin resistance in both type 2 diabetes patients and the healthy population all over the world


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Created by admin. Last Modification: Wednesday June 30, 2021 17:41:18 GMT-0000 by admin. (Version 8)

Attached files

ID Name Comment Uploaded Size Downloads
15857 IR Glucose.jpg admin 30 Jun, 2021 17:39 42.90 Kb 35
15850 Diabetic IR.jpg admin 30 Jun, 2021 00:36 32.76 Kb 80
15849 Non diabetic IR.jpg admin 30 Jun, 2021 00:35 69.96 Kb 87
15848 Insulin Resistance_compressed.pdf PDF 2021 admin 30 Jun, 2021 00:35 658.43 Kb 23
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