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Diabetic hypertension reduced with Vitamin D and Calcium – RCT March 2015

Effects of Calcium Plus Vitamin D Supplementation on Anthropometric Measurements and Blood Pressure in Vitamin D Insufficient People with Type 2 Diabetes: A Randomized Controlled Clinical Trial.

J Am Coll Nutr. 2015 Mar 4:1-9. [Epub ahead of print]
Tabesh M1, Azadbakht L, Faghihimani E, Tabesh M, Esmaillzadeh A.

VitaminDWiki Summary

50,000 IU vitamin D weekly + 1000 mg/d Calcium vs placebos
Systolic blood pressure reduced by 8 mmHg in 8 weeks
Suspect weight loss would have been measured if any of the following

  1. Trial had lasted longer than 8 weeks (takes >12 weeks for that dose to be effective)
  2. More vitamin D was used (obese need 2-3X more vitamin D)
  3. Magnesium was also used

Background: Up to 75% of the risk of type 2 diabetes is attributable to obesity. Therefore, finding a way to control obesity can be useful for management of diabetes. Objective: This study was performed to assess the effects of vitamin D3 and calcium supplementation on anthropometric measurements and blood pressure in vitamin D insufficient people with type 2 diabetes.

Methods: One hundred eighteen patients with diabetes were enrolled in this randomized placebo-controlled clinical trial. All subjects were randomly assigned into 4 groups receiving

  • (1) 50,000 IU/wk vitamin D3 plus (equal to 7143 IU/d) calcium placebo;
  • (2) 1000 mg/d calcium plus vitamin D3 placebo;
  • (3) 50,000 IU/wk vitamin D3 (equal to 7143 IU/d) plus 1000 mg/d calcium; or
  • 4) vitamin D3 placebo plus calcium placebo for 8 weeks.

Anthropometric measurements and blood pressure were assessed at study baseline and after 8 weeks of intervention.

Results: A greater reduction in body mass index was observed in calcium plus vitamin D group than other groups (p = 0.03). Comparison of changes in waist circumference among 4 groups revealed no significant difference in crude model (p = 0.21) and when the effect of confounders was taken into account (p = 0.08). Calcium supplementation resulted in a significant reduction in hip circumference compared to other groups (p <0.001). Systolic blood pressure significantly decreased in the calcium plus vitamin D group compared to placebo (-7.3 ± 8.7 mmHg vs 0.5 ± 8.2 mmHg; p = 0.001). However, calcium and vitamin D supplementation had no significant effects on diastolic blood pressure.

Conclusion: Calcium-vitamin D3 cosupplementation can have beneficial effect on body mass index (BMI), hip circumference, and systolic blood pressure in vitamin D-insufficient type 2 diabetics.

PMID: 25738212


See also VitaminDWiki

Pages listed in BOTH the categories Diabetes and Obesity

Pages listed in BOTH the categories Magnesium and Obesity

Pages listed in BOTH the categories Magnesium and Diabetes

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