There are two gestational diabetes mellitus meta-analyses on this page
Efficacy of vitamin D supplementation in gestational diabetes mellitus: Systematic review and meta-analysis of randomized trials.
PLoS One. 2019 Mar 22;14(3):e0213006. doi: 10.1371/journal.pone.0213006. eCollection 2019.
Rodrigues MRK1, Lima SAM2, Mazeto GMFDS3, Calderon IMP1, Magalhães CG1, Ferraz GAR1, Molina AC4, Costa RAA1, Nogueira VDSN3, Rudge MVC1.
Items in all 3 categories Diabetes AND Pregnancy AND Meta-analysis are listed here:
- Gestational diabetes risk reduced 1.5X by Vitamin D – meta-analysis March 2021
- Gestational Diabetes – increased risk if poor Vitamin D Receptor – 2 Meta-Analyses 2021
- Vitamin D treats Gestational Diabetes, decreases hospitalization and newborn complications – meta-analysis March 2019
- Gestational Diabetes 39 percent more likely if insufficient Vitamin D – Meta-analysis March 2018
- Gestational Diabetes Mellitus 1.5X more likely if low vitamin D – meta-analysis Oct 2015
- Gestational diabetes 60 percent more likely below 20 ng of vitamin D – meta-analysis Feb 2012
Items in both categories Diabetes and Pregnancy are listed here:
- Gestational Diabetes Risk is increased 4.2 X if low Vitamin K2 MK-7 - Jan 2025
- Gestational Diabetes best fought by Vitamin D plus probiotics – RCT review Dec 2023
- Diabetes 30% more likely in those with low birth weight - June 2023
- Gestational Diabetes Mellitus 10X more-likely if low vitamin D in first trimester – July 2022
- Gestational Diabetes 2.1 X more likely if less than 30 ng of Vitamin D - July 2022
- Gestational diabetes risk reduced 1.5X by Vitamin D – meta-analysis March 2021
- Gestational Diabetes – increased risk if poor Vitamin D Receptor – 2 Meta-Analyses 2021
- Gestational Diabetes 2.4X more likely if poor Vitamin D Receptor (region in China) – June 2019
- Vitamin D food fortification during pregnancy reduced gestational diabetes in daughters by 13 percent – Nov 2018
- Gestational Diabetes 3 X more likely if poor Vitamin D receptor (Turkey) – May 2019
- Type 1 Diabetes risk increased if high postpartum Vitamin D binding protein – Jan 2019
- Vitamin D treats Gestational Diabetes, decreases hospitalization and newborn complications – meta-analysis March 2019
- Maternal Diabetes and Risk of Autism in Offspring – JAMA June 2018
- Gestational Diabetes 39 percent more likely if insufficient Vitamin D – Meta-analysis March 2018
- Gestational Diabetes 1.9 X more likely if low vitamin D – review Dec 2017
- Congenital Heart Disease is associated with gestational diabetes in first trimester (need Vitamin D and Omega-3 early) Dec 2017
- Gestational Diabetes Mellitus associated with 4 Vitamin D genes – Oct 2015
- Gestational diabetes 30 percent less likely if consumed more than 400 IU of vitamin D daily – Oct 2017
- Low vitamin D plus gestational diabetes resulted in increased ICU use, SGA – Oct 2016
- Gestational diabetes treated by Vitamin D plus Omega-3 – RCT Feb 2017
- Gestational Diabetes reduce 3 times by 5,000 IU of Vitamin D – RCT Jan 2016
- Gestational Diabetes treated with 50,000 IU every two weeks – RCT Sept 2016
- Low vitamin D in pregnancy – epigenetic pancreas problems in offspring (mice) – May 2016
- MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015
- Gestational Diabetes 3.7 X more likely if smoke and have low vitamin D (no surprise) – Feb 2016
- Gestational Diabetes helped by Vitamin D and Calcium (also less C-section and LGA) – RCT Jan 2016
- T1 Diabetes in child not prevented by a tiny amount of vitamin D during pregnancy – Nov 2015
- Gestational Diabetes Mellitus 1.5X more likely if low vitamin D – meta-analysis Oct 2015
- Gestational Diabetes increasing, especially in dark skinned women (low vitamin D) - 2007
- Increased Gestational Diabetes and poorer infant health associated with low vitamin D – June 2015
- Gestational Diabetes in 10 percent of pregnancies, vitamin D probably helps – Jan 2014
- Gestational diabetes – Vitamin D and Calcium provided huge benefits – RCT March 2015
- Gestational diabetes reduced by just two 50,000 IU doses of vitamin D – RCT Nov 2014
- Gestational Diabetes reduced with 50,000 IU of vitamin D every 3 weeks and daily Calcium – RCT June 2014
- Gestational Diabetes reduced 40 percent by 5,000 IU of vitamin D – RCT April 2014
- Insulin resistance during pregnancy improved with 50,000 IU of vitamin D every 2 weeks – RCT April 2013
- Will 1600 IU vitamin D prevent gestational diabetes – no, not enough, July 2013
- Vitamin D protects against many types of health problems – review May 2013
- Dr. Holick video on vitamin D - March 2013
- Gestational diabetes 2.2X more likely below 10 ng of vitamin D – June 2012
- Gestational diabetes 60 percent more likely below 20 ng of vitamin D – meta-analysis Feb 2012
- Type I diabetes 2X more likely if mother had low vitamin D – Jan 2012
- 300,000 IU injection loading dose of vitamin D3 stopped gestational diabetes in RCT – Oct 2011
- Less muscle and insulin resistance for children of vitamin D deficient mothers – Jan 2011
- Vitamin D Levels at Birth May Predict Obesity Risk at age 3 - Oct 2010
Download the PDF from VitaminDWiki
BACKGROUND: Trials have examined on the benefits of vitamin D supplementation in pregnant women.
OBJECTIVE:
This review aimed to evaluate whether oral vitamin D supplements, when given to pregnant women with gestational diabetes mellitus (GDM), would improve maternal and neonatal outcomes, compared with no treatment or placebo.
METHOD:
We performed a systematic review following Cochrane methodology, and randomized trials were included where pregnant women with GDM received vitamin D supplementation versus placebo/no treatment or vitamin D and calcium versus placebo/no treatment. Primary outcomes were preeclampsia, preterm birth, cesarean delivery, gestational hypertension, and adverse events related to vitamin D supplementation. The search strategies were applied to the following databases: MEDLINE, Embase, LILACS, and CENTRAL. Similar outcomes in at least two trials were plotted using Review Manager 5.3 software. The quality of evidence was generated according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE).
RESULTS:
The total of 1224 references were identified, eleven trials were potentially eligible, and six were included in this review (totaling 456 women). The meta-analysis of frequency of cesarean deliveries did not show significant differences between groups, none of the trials evaluated the remaining primary outcomes. For secondary outcomes, our results suggest that vitamin D supplementation in pregnant women with GDM
may reduce newborn complications such as
- Hyperbilirubinemia, RR: 0.40, 95% CI: 0.23 to 0.68;
- Polyhydramnios RR: 0.17, 95% CI: 0.03 to 0.89;
- maternal hospitalization (RR: 0.13; 95% CI: 0.02 to 0.98;
- infant hospitalization RR: 0.40, 95% CI: 0.23 to 0.69.
However, the evidence was of low or very low quality.
CONCLUSION:
We did not find moderate or high quality evidence indicating that vitamin D supplementation, when compared with placebo, improves glucose metabolism, adverse maternal and neonatal outcomes related to GDM in pregnant women.
[Effect of vitamin D supplementation on gestational diabetes mellitus:a Meta-analysis] - Sept 2019
Wei Sheng Yan Jiu. 2019 Sep;48(5):811-821. [ Article in Chinese]
Yin W1, Jin D1, Yao M1, Yu W1, Zhu P1.
Department of Maternal, Child & Adolescent Health, School of Public Health, Xiangcheng District, Suzhou 230032, China.
OBJECTIVE:
This Meta-analysis of randomized controlled trial( RCT) was conducted to summarize the preventive and therapeutic effects of vitamin D supplementation on gestational diabetes mellitus( GDM).
METHODS:
The electronic database( CNKI, CBM, VIP, PubMed, Cochrane library, Web of Science) were systematically searched from inception to February 2018, using the keywords vitamin D and gestational diabetes to identify Meta-analysis.
RESULTS:
A total of 16 RCTs were included. A total of 6 RCTs were included for the prevention of GDM by vitamin D supplementation. Meta-analysis indicated that vitamin D supplementation significantly reduced the level of fasting plasma glucose( FPG)( SMD =-1. 87, 95% CI-3. 39- 0. 35) and the incidence of GDM( OR = 0. 42, 95% CI 0. 30-0. 60) in pregnant women. Ten RCTs were included for the treatment of GDM by vitamin D supplementation. Meta-analysis indicated that vitamin D supplementation significantly reduced the level of fasting plasma glucose( FPG)( SMD =-0. 29, 95% CI-0. 56- 0. 02) and Fasting Insulin( FINS)( SMD =-0. 42, 95% CI-0. 69- 0. 15), also improved the homeostasis model of assessment-estimated insulin resistance( HOMA-IR)( SMD =-0. 53, 95% CI-0. 890. 17) and the homeostasis model of assessment-estimated B cell function( HOMA-β)( SMD =-0. 39, 95% CI-0. 610. 18), and increased the quantitative insulin sensitivity check index( QUICKI)( SMD = 0. 87, 95% CI 0. 41-1. 32) in GDM patients.
CONCLUSION:
supplementation may prevent and treat GDM by an improvement in HOMA-IR, HOMA-IR and QUICKI.