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Gestational diabetes treated by Vitamin D plus Omega-3 – RCT Feb 2017


The effects of vitamin D and omega-3 fatty acid co-supplementation on glycemic control and lipid concentrations in patients with gestational diabetes - Feb 2017

Journal of Clinical Lipidology, online 2 Feb 2017, http://dx.doi.org/10.1016/j.jacl.2017.01.011
Mehri Jamilian, MD1, Mansooreh Samimi, MD2, Faraneh Afshar Ebrahimi, MD2, Teibeh Hashemi, MD3, Mohsen Taghizadeh, PhD3, Maryamalsadat Razavi, MD4, , , Marzieh Sanami, BSc3, Zatollah Asemi, PhD3, ,

VitaminDWiki Summary

Trial was only 6 weeks – hardly enough time to get to a good level of vitamin D
Longer trial or starting with loading dose would have had much better results

No Vitamin D
2000mg Omega3
600mg EPA
480mg DHA
50,000 IU Vit D*50,000 IU Vit D*
2000 mg Omega3
No Vitamin D
No Omega-3
fasting plasma glucose-7 -7 -4 +1
serum insulin levels-1-10+3
HOMA-IR -0.7-0.-0.2+0.6
serum triglycerides-8 +8+4 +20
VLDL-cholesterol-2+20`+4

* every 2 weeks, otherwise daily


Objective
This study was performed to evaluate the effects of vitamin D and omega-3 fatty acids co- supplementation on glucose metabolism and lipid concentrations in gestational diabetes (GDM) patients.

Methods
This randomized double-blind placebo-controlled clinical trial was done among 140 GDM patients. Participants were randomly divided into four groups to receive:

  • 1) 1000 mg omega-3 fatty acids containing 360 mg eicosapentaenoic acid (EPA) and 240 mg docosahexaenoic acid (DHA) twice a day+ vitamin D placebo (n=35);
  • 2) 50,000 IU vitamin D every 2 weeks+ omega-3 fatty acids placebo (n=35);
  • 3) 50,000 IU vitamin D every 2 weeks+1000 mg omega-3 fatty acids twice a day (n=35) and
  • 4) vitamin D placebo+omega-3 fatty acids placebo (n=35) for 6 weeks.

Results
After 6 weeks of intervention, patients who received combined vitamin D and omega-3 fatty acids supplements compared with vitamin D, omega-3 fatty acids and placebo had significantly decreased

  • fasting plasma glucose (FPG) (-7.3±7.8, -6.9±6.6, -4.0±2.5 and +1.0±11.4 mg/dL, respectively, P<0.001),
  • serum insulin levels (-1.9±1.9, -1.3±6.3, -0.4±6.3 and +2.6±6.5 μIU/mL, respectively, P=0.005),
  • homeostatic model of assessment for insulin resistance (HOMA-IR) (-0.7±0.6, -0.5±1.4, -0.2±1.5 and +0.6±1.5, respectively, P<0.001)
  • increased quantitative insulin sensitivity check index (QUICKI) (+0.01±0.01, +0.008±0.02, +0.002±0.02 and -0.005±0.02, respectively, P=0.001). In addition, changes in
  • serum triglycerides (-8.2±41.0, +7.6±31.5, +3.6±29.9 and +20.1±29.6 mg/dL, respectively, P=0.006) and
  • VLDL-cholesterol (-1.6±8.2, +1.5±6.3, +0.8±6.0 and +4.0±5.9 mg/dL, respectively, P=0.006) in the vitamin D plus omega-3 fatty acids group were significantly different from the changes in these indicators in the vitamin D, omega-3 fatty acids and placebo groups.

Conclusion
Overall, vitamin D and omega-3 fatty acids co-supplementation for 6 weeks among GDM patients had beneficial effects on FPG, serum insulin levels, HOMA-IR, QUICKI, serum triglycerides and VLDL-cholesterol levels.

Publisher wants $36 for the PDF


The effects of vitamin D and omega-3 fatty acids co-supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in patients with gestational diabetes - Dec 2017

It appears the same RCT was re-published with free PDF later in 2017
Nutrition & Metabolism201714:80, https://doi.org/10.1186/s12986-017-0236-9. Dec 2017
Maryamalsadat Razavi, Mehri Jamilian, Mansooreh Samimi, Faraneh Afshar Ebrahimi, Mohsen Taghizadeh, Reza Bekhradi, Elahe Seyed Hosseini, Hamed Haddad Kashani, Maryam Karamali and Zatollah Asemi
 Download the PDF from VitaminDWiki
Grassroots Health Plot of Data
Image

Image
Nice outcome trends for this short small study
Anticipate that a long study with more mothers would get many statistically significant results

Image

Background
This study was carried out to determine the effects of vitamin D and omega-3 fatty acids co- supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes (GDM) patients.

METHODS:
This randomized, double-blind, placebo-controlled trial was conducted among 120 GDM women.
Participants were randomly divided into four groups to receive:

  • 1) 1000 mg omega-3 fatty acids containing 180 mg eicosapentaenoic acid (EPA) and 120 mg docosahexaenoic acid (DHA) twice a day + vitamin D placebo (n = 30);
  • 2) 50,000 IU vitamin D every 2 weeks + omega-3 fatty acids placebo (n = 30);
  • 3) 50,000 IU vitamin D every 2 weeks + 1000 mg omega-3 fatty acids twice a day (n = 30) and
  • 4) vitamin D placebo + omega-3 fatty acids placebo (n = 30) for 6 weeks.

Results
Subjects who received vitamin D plus omega-3 fatty acids supplements compared with vitamin D, omega-3 fatty acids and placebo had significantly decreased high-sensitivity C-reactive protein (−2.0 ± 3.3 vs. -0.8 ± 4.4, −1.3 ± 2.4 and +0.9 ± 2.7 mg/L, respectively, P = 0.008), malondialdehyde (−0.5 ± 0.5 vs. −0.2 ± 0.5, −0.3 ± 0.9 and +0.5 ± 1.4 μmol/L, respectively, P < 0.001), and increased total antioxidant capacity (+92.1 ± 70.1 vs. +55.1 ± 123.6, +88.4 ± 95.2 and +1.0 ± 90.8 mmol/L, respectively, P = 0.001) and glutathione (+95.7 ± 86.7 vs. +23.0 ± 62.3, +30.0 ± 66.5 and −7.8 ± 126.5 μmol/L, respectively, P = 0.001). In addition, vitamin D and omega-3 fatty acids co-supplementation, compared with vitamin D, omega-3 fatty acids and placebo, resulted in lower incidences of newborns’ hyperbilirubinemiain (P = 0.037) and newborns’ hospitalization (P = 0.037).

Conclusion
Overall, vitamin D and omega-3 fatty acids co-supplementation for 6 weeks among GDM women had beneficial effects on some biomarkers of inflammation, oxidative stress and pregnancy outcomes.


See also VitaminDWiki

Overview: Omega-3 many benefits include helping vitamin D
Overview Loading of vitamin D contains the following

Loading dose: 190 studies at VitaminDWiki

Vitamin D loading dose (stoss therapy) proven to improve health overview
If a person is or is suspected to be, very vitamin D deficient a loading dose should be given

  • Loading = restore = quick replacement by 1 or more doses
  • Loading doses range in total size from 100,000 IU to 1,000,000 IU of Vitamin D3
    • = 2.5 to 25 milligrams
  • The size of the loading dose is a function of body weight - see below
    • Unfortunately, some doctors persist in using Vitamin D2 instead of D3
  • Loading may be done as quickly as a single day (Stoss), to as slowly as 3 months.
    • It appears that spreading the loading dose over 4+ days is slightly better if speed is not essential
  • Loading is typically oral, but can be Injection (I.M,) and Topical
  • Loading dose is ~3X faster if done topically or swished inside of the mouth
    • Skips the slow process of stomach and intestine, and might even skip liver and Kidney as well
  • The loading dose persists in the body for 1 - 3 months
    • The loading dose should be followed up with on-going maintenance dosing
    • Unfortunately, many doctors fail to follow-up with the maintenance dosing.
  • About 1 in 300 people have some form of a mild allergic reaction to vitamin D supplements, including loading doses
    • it appears prudent to test with a small amount of vitamin D before giving a loading dose
    • The causes of a mild allergic reaction appear to be: (in order of occurrence)
    • 1) lack of magnesium - which can be easily added
    • 2) allergy to capsule contents - oil, additives (powder does not appear to cause any reaction)
    • 3) allergy to the tiny amount of D3 itself (allergy to wool) ( alternate: D3 made from plants )
    • 4) allergy of the gut to Vitamin D - alternative = topical

VitaminDWiki - 39 studies listed in BOTH of the categories Omega-3 and Pregnancy


VitaminDWiki with GESTATIONAL DIABETES in title (36 as of July 2022)

This list is automatically updated

Items found: 38
Title Modified
Gestational Diabetes Mellitus 10X more-likely if low vitamin D in first trimester – July 2022 07 Aug, 2022
Gestational Diabetes 2.1 X more likely if less than 30 ng of Vitamin D - July 2022 14 Jul, 2022
Gestational diabetes risk reduced 1.5X by Vitamin D – meta-analysis March 2021 14 Jul, 2022
Vitamin D reduces preeclampsia, gestational diabetes and hypertension - 38th meta-analysis Dec 2021 31 May, 2022
Gestational Diabetes – increased risk if poor Vitamin D Receptor – 2 Meta-Analyses 2021 14 Dec, 2021
Vitamin D reduces pre-eclampsia, gestational diabetes and hypertension - 38th meta-analysis Dec 2021 05 Dec, 2021
50,000 IU of Vitamin D every 2 weeks reduced gestational diabetes – RCT Feb 2015 15 Aug, 2020
300,000 IU injection loading dose of vitamin D3 stopped gestational diabetes in RCT – Oct 2011 25 Jul, 2020
Vitamin D cuts pregnancy risks in half – low birth weight, preeclampsia, gestational diabetes – Cochrane July 2019 12 Sep, 2019
Gestational Diabetes 2.4X more likely if poor Vitamin D Receptor (region in China) – June 2019 24 Jun, 2019
Vitamin D food fortification during pregnancy reduced gestational diabetes in daughters by 13 percent – Nov 2018 14 Jun, 2019
Gestational Diabetes 3 X more likely if poor Vitamin D receptor (Turkey) – May 2019 18 May, 2019
Gestational diabetes 60 percent more likely below 20 ng of vitamin D – meta-analysis Feb 2012 23 Mar, 2019
Vitamin D treats Gestational Diabetes, decreases hospitalization and newborn complications – meta-analysis March 2019 23 Mar, 2019
Gestational Diabetes 39 percent more likely if insufficient Vitamin D – Meta-analysis March 2018 17 Mar, 2018
Gestational Diabetes Mellitus 1.5X more likely if low vitamin D – meta-analysis Oct 2015 07 Feb, 2018
Gestational diabetes treated by Vitamin D plus Omega-3 – RCT Feb 2017 02 Jan, 2018
Gestational Diabetes increasing, especially in dark skinned women (low vitamin D) - 2007 30 Dec, 2017
Gestational Diabetes 1.9 X more likely if low vitamin D – review Dec 2017 15 Dec, 2017
Congenital Heart Disease is associated with gestational diabetes in first trimester (need Vitamin D and Omega-3 early) Dec 2017 15 Dec, 2017
Vitamin D Receptor is associated with preeclampsia, gestational diabetes and preterm birth – Nov 2017 10 Nov, 2017
Gestational Diabetes Mellitus associated with 4 Vitamin D genes – Oct 2015 09 Nov, 2017
Gestational diabetes 30 percent less likely if consumed more than 400 IU of vitamin D daily – Oct 2017 04 Oct, 2017
Low vitamin D plus gestational diabetes resulted in increased ICU use, SGA – Oct 2016 07 Jun, 2017
Gestational Diabetes 3.7 X more likely if smoke and have low vitamin D (no surprise) – Feb 2016 04 Jan, 2017
Gestational Diabetes reduce 3 times by 5,000 IU of Vitamin D – RCT Jan 2016 10 Dec, 2016
Gestational Diabetes reduced with 50,000 IU of vitamin D every 3 weeks and daily Calcium – RCT June 2014 03 Sep, 2016
Gestational Diabetes treated with 50,000 IU every two weeks – RCT Sept 2016 03 Sep, 2016
Infant much healthier if Gestational Diabetic mother got 2 doses of vitamin D – RCT Nov 2014 09 Apr, 2016
Gestational Diabetes helped by Vitamin D and Calcium (also less C-section and LGA) – RCT Jan 2016 16 Jan, 2016
Gestational diabetes – Vitamin D and Calcium provided huge benefits – RCT March 2015 13 Jan, 2016
Gestational diabetes reduced by just two 50,000 IU doses of vitamin D – RCT Nov 2014 02 Oct, 2015
Increased Gestational Diabetes and poorer infant health associated with low vitamin D – June 2015 01 Jul, 2015
Gestational Diabetes in 10 percent of pregnancies, vitamin D probably helps – Jan 2014 14 Apr, 2015
Gestational Diabetes reduced 40 percent by 5,000 IU of vitamin D – RCT April 2014 02 Mar, 2015
Gestational Diabetes mostly treated with just 2 doses of 50,000 IU of vitamin D – RCT Dec 2013 26 Jun, 2014
Will 1600 IU vitamin D prevent gestational diabetes – no, not enough, July 2013 31 Aug, 2013
Gestational diabetes 2.2X more likely below 10 ng of vitamin D – June 2012 15 Nov, 2012

Attached files

ID Name Comment Uploaded Size Downloads
12289 GRH O3 and D3.jpg admin 09 Jul, 2019 19:53 75.54 Kb 664
9099 Vit D O-3 outcomes.jpg admin 02 Jan, 2018 12:04 69.31 Kb 722
9098 GD with Vit D and O-3.jpg admin 02 Jan, 2018 12:04 37.66 Kb 766
9097 D3 + Omega-3 during pregnancy.pdf admin 02 Jan, 2018 11:48 1.09 Mb 620
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