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Diabetes not prevented or treated if give only modest amount of vitamin D or for short period of time – meta-analysis July 2014

Effect of Vitamin D3 Supplementation on Improving Glucose Homeostasis and Preventing Diabetes: A Systematic Review and Meta-Analysis

The Journal of Clinical Endocrinology & Metabolism DOI: http://dx.doi.org/10.1210/jc.2014-2136
Jennifer C. Seida MPH1, Joanna Mitri MD2, Isabelle N. Colmers MSc1, Sumit R. Majumdar MD1,3, Mayer B. Davidson MD4, Alun L. Edwards MD5, David A. Hanley MD5, Anastassios G. Pittas MD2, Lisa Tjosvold MLIS1, and Jeffrey A. Johnson PhD1
1Alliance for Canadian Health Outcomes Research in Diabetes, University of Alberta, Edmonton;
2Tufts Medical Center, Boston;
3Division of General Internal Medicine, Department of Medicine, University of Alberta, Edmonton;
4Charles R Drew University, Los Angeles;
5University of Calgary, Calgary

Observational studies report consistent associations between low vitamin D concentration and increased glycemia and risk of type 2 diabetes, but results of randomized controlled trials (RCTs) are mixed.
To systematically review RCTs that report on the effects of vitamin D supplementation on glucose homeostasis or diabetes prevention.
Data Sources:
MEDLINE, EMBASE, SCOPUS, Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effects, Health Technology Assessment, and Science Citation Index from inception to June 2013.
Study Selection:
Trials that compared vitamin D3 supplementation with placebo or a non-vitamin D supplement in adults with normal glucose tolerance, prediabetes, or type 2 diabetes.
Data Extraction and Synthesis:
Two reviewers collected data and assessed trial quality using the Cochrane Risk of Bias tool. Random effects models were used to estimate mean differences (MD) and odds ratios (OR). The main outcomes of interest were HOMA–IR, HOMA–B, hemoglobin A1c levels, fasting blood glucose, incident diabetes, and adverse events.
Data Synthesis:
Thirty-five trials (43,407 patients) with variable risk of bias were included. Vitamin D had no significant effects on insulin resistance (HOMA–IR: MD, -0.04; 95%CI, -0.30 to 0.22, I2=45%), insulin secretion (HOMA–B: MD, 1.64; 95%CI, -25.94 to 29.22, I2=40%), or A1c (MD, -0.05%; 95%CI, -0.12 to 0.03, I2=55%) compared with controls. Four RCTs reported on progression to new diabetes and found no effect of vitamin D (OR, 1.02; 95%CI, 0.94 to 1.10, I2=0%). Adverse events were rare, and there was no evidence of publication bias.
Evidence from available trials shows no effect of vitamin D3 supplementation on glucose homeostasis or diabetes prevention. Definitive conclusions may be limited in the context of the moderate degree of heterogeneity, variable risk of bias, and short-term follow-up duration of the available evidence to date.

PDF is attached at the bottom of this page

Only noticed 3 studies which lasted long enough (> 4 months) which also used enough vitamin D (>4,000 IU) for the average adult
Unfortunately, they were for studies of OBESE adults - who need 8,000 - 12,000 IU

See also VitaminDWiki

Overview Diabetes and vitamin D contains the following summary

  • Diabetes is 5X more frequent far from the equator
  • Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
  • Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
  • Sedentary people get less sun / Vitamin D
  • Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
  • Elderly get 4X less vitamin D from the same amount of sun
        Elderly also spend less time outdoors and have more clothes on
  • All items in category Diabetes and Vitamin D 450 items: both Type 1 and Type 2

Vitamin D appears to both prevent and treat diabetes

  • Appears that >2,000 IU will Prevent
  • Appears that >4,000 IU will Treat , but not cure
  • Appears that Calcium and Magnesium are needed for both Prevention and Treatment
    • which are just some of the vitamin D cofactors

Number of articles in both categories of Diabetes and:

  • Dark Skin 22;   Intervention 49;   Meta-analysis 28;   Obesity 26;  Pregnancy 39;   T1 (child) 34;  Omega-3 10;  Vitamin D Receptor 18;  Genetics 10;  Magnesium 18    Click here to see details

Pages listed in BOTH the categories Diabetes and Meta-analysis

Attached files

ID Name Comment Uploaded Size Downloads
4193 Diabetes T1.jpg admin 26 Jul, 2014 19:28 314.02 Kb 626
4192 Diabetes meta-analysis July 2014.pdf PDF 2014 admin 26 Jul, 2014 19:27 984.45 Kb 1496
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