Dietary vitamin D3 improves postprandial hyperglycemia in aged mice.
Biochem Biophys Res Commun. 2015 Apr 10. pii: S0006-291X(15)00674-9. doi: 10.1016/j.bbrc.2015.04.008. [Epub ahead of print]
Enciso PL1, Wang L2, Kawahara Y2, Sakamoto S2, Shimada S2, Takeichi Y2, Takayanagi R2, Nomura M3.
1Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Maidashi 3-1-1, Higashi ward, Fukuoka 812-8582, Japan; Universidad Catolica Nuestra Señora de la Asunciòn, Independencia Nacional 176 y Comuneros C.C 1718, Asunción, Paraguay.
2Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Maidashi 3-1-1, Higashi ward, Fukuoka 812-8582, Japan.
3Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Maidashi 3-1-1, Higashi ward, Fukuoka 812-8582, Japan. Electronic address: nomura at med.kyushu-u.ac.jp.
Type 2 Diabetes is closely associated with our daily diets and has become a global health problem with an increasing number of patients. Recent observational and randomized studies on vitamin D3 suggested that higher plasma 25-hydroxyvitamin D3 [25(OH)D3] concentrations and more vitamin D3 intake are associated with lower risk of type 2 diabetes, which is characterized by postprandial hyperglycemia due to inappropriate glucose stimulated insulin secretion (GSIS) and its age-dependent increase of onset. However, rapid action of dietary vitamin D3 on the postprandial glucose profile has not been analyzed. When vitamin D3 is orally ingested in mice aged 12-14 weeks during an oral glucose tolerance test (OGTT), the serum glucose profile was not changed. In contrast, when OGTT was performed with old mice aged 30-34 weeks, the glucose profile was dramatically improved with increased insulin secretion, suggesting that orally ingested vitamin D3 potentiated GSIS in aged mice. Interestingly, there was also a significant increase in plasma GLP-1 in these aged mice. Our results suggest that orally ingested dietary vitamin D3 in aged mice improves glucose metabolism as a GLP-1 enhancer.
Copyright © 2015. Published by Elsevier Inc.
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PMID: 25869067
See also VitaminDWiki
- Overview Diabetes and vitamin D contains the following summary
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- Appears that >2,000 IU will Prevent
- Appears that >4,000 IU will Treat , but not cure
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- Dark Skin
24 ; Intervention 56 ; Meta-analysis 39 ; Obesity 36 ; Pregnancy 44 ; T1 (child) 39 ; Omega-3 11 ; Vitamin D Receptor 24 ; Genetics 13 ; Magnesium 29 Click here to see details Some Diabetes studies
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- T1 Diabetes 3X lower risk if high vitamin D (over 40 ng) – Meta-analysis Nov 2020
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Pre-Diabetes
- 4X reduction in prediabetes progressing to T2D if more than 50 ng of vitamin D – RCT March 2023
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Pages listed in BOTH the categories Diabetes and SeniorsSee also web
- GLP-1 Wikipedia
Diabetes decreased in aged mice supplemented with vitamin D – April 20156049 visitors, last modified 06 May, 2015, This page is in the following categories (# of items in each category)