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Diabetic inflammation reduced by Calcium and 50,000 IU of vitamin D in 8 weeks – RCT 2014

Calcium-vitamin D co-supplementation influences circulating inflammatory biomarkers and adipocytokines in vitamin D insufficient diabetics: a randomized controlled clinical trial

Marjan Tabesh 1,2, Leila Azadbakht 1,2, Elham Faghihimani 3, Maryam Tabesh 1, and Ahmad Esmaillzadeh 1,2
1Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran;
2Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran;
3Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Received: April 07, 2014; Accepted: August 05, 2014; Published Online: September 12, 2014

Context:
To the best of our knowledge, no study has examined the effects of vitamin D-calcium co-supplementation on inflammatory biomarkers and adipocytokines in vitamin D insufficient type 2 diabetics.
Objective:
This study was performed to assess the effects of vitamin D and calcium supplementation on inflammatory biomarkers and adipocytokines in vitamin D insufficient people with type 2 diabetes.
Methods:
Totally, 118 diabetic patients were enrolled in this randomized placebo controlled clinical trial. After matching for age, sex, body mass index, type and dose of hypoglycemic agents and duration of diabetes, subjects were randomly assigned into four groups receiving:

  • 1) 50000 IU/wk vitamin D + calcium placebo;
  • (2) 1000 mg/d calcium+vitamin D placebo;
  • 3) 50000 IU/wk vitamin D + 1000 mg/d calcium;
  • 4) vitamin D placebo+calcium placebo for 8 weeks.

Blood sampling was done for quantification of inflammatory biomarkers and adipocytokines at study baseline and after 8 weeks of intervention.
Results:
Calcium (changes from baseline: -75±19 ng/ml, P=0.01) and vitamin D alone (-56±19 ng/ml, P=0.01) and joint calcium-vitamin D supplementation (-92±19 ng/ml, P=0.01) resulted in a significant reduction in serum leptin levels compared with placebo (-9±18 ng/ml). This was also the case for serum IL-6; such that calcium (-2±1 pg/ml, P<0.001) and vitamin D alone (-4±1 pg/ml, P<0.001) and their combination (-4±1 pg/ml, P<0.001) led to significant reductions compared with placebo (3±1 pg/ml). After adjustment for potential confounders, individuals in calcium (-3.1±1.3, P<0.05), vitamin D (-3.1±1.3, P<0.05) and joint Ca-D groups (-3.4±1.3, P<0.05) had greater reductions in serum TNF-α concentrations compared with placebo (0.1±1.2). Individuals who received joint calcium-D supplements tended to have a decrease in serum hs-CRP levels compared with placebo after controlling for baseline levels (-1.14±0.25 vs. 0.02±0.24 ng/ml, P=0.09).
Conclusion:
Joint calcium-vitamin D supplementation might improve systemic inflammation through decreasing IL-6 and TNF-α concentrations in vitamin D insufficient people with type 2 diabetes.
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Comment by VitaminDWiki:

Would have been even more successful if they had :

  • used a loading dose of vitamin D - say 200,000 to 400,000 IU in the first week
  • extended the trial longer
  • Had also used Magnesium

See also VitaminDWiki

Pages listed in BOTH the categories Diabetes and Magnesium

Pages listed in BOTH the categories Omega-3 and Inflammation

See blog post of the study at Vitamin D Council

Vitamin D and calcium supplementation administered together and separately improve inflammatory markers Sept 2014

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Created by admin. Last Modification: Monday July 1, 2019 17:10:16 GMT-0000 by admin. (Version 8)

Attached files

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4361 Diabetes inflammation reduced.jpg admin 14 Sep, 2014 16:00 95.05 Kb 1348
4360 Diabetes inflammation reduced.pdf PDF 2014 admin 14 Sep, 2014 15:59 225.42 Kb 949
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