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Gestational diabetes risk reduced 1.5X by Vitamin D – meta-analysis March 2021


Dietary supplementation for gestational diabetes prevention and management: a meta-analysis of randomized controlled trials - March 2021

Arch Gynecol Obstet. 2021 Mar 21. doi: 10.1007/s00404-021-06023-9
Kwan Yi Chan 1, Martin Ming Him Wong 2, Sally Shuk Han Pang 3, Kenneth Ka Hei Lo 4

Purpose: The use of supplement to prevent and ease gestational diabetes (GDM) progression has been examined in various studies, but the results were inconclusive, and studies evaluated dietary supplements separately. The present review aimed to evaluate the efficacy of various dietary supplementation on GDM risk and the surrogate markers for cardiometabolic risk of pregnant women with GDM.

Methods: A comprehensive search on multiple databases were performed to identify randomized controlled trials. Random-effects model was used to pool the results in relative risk (RR) or mean difference.

Results: Fifty-three randomized controlled studies with 9443 pregnant women were included. Vitamin D (5 studies, RR 0.64; 95% CI 0.44, 0.94) and myo-inositol (4 studies, RR 0.34, 95% CI 0.20, 0.58) supplementation significantly reduced the risk of GDM. Myo-inositol, probiotics, and vitamin D showed significant intervention effect on surrogate markers related to glycemic control, lipid profile, inflammatory, and oxidative stress. However, the majority of included studies were clustered to Iran and Italy, which might convey a generalizability bias.

Conclusion: Dietary supplementation including vitamin D and myoinositol supplementation has the potential in primary prevention and management of GDM, whereas probiotics demonstrated its ability in GDM management by improving the levels of surrogate markers for cardiometabolic risk. The potential for dietary supplement in preventing GDM or managing cardiometabolic risk of pregnant women should receive more attentions.


GDM 1.26X more likely if low vitamin D - Meta-analysis April 2021

Maternal vitamin D status and risk of gestational diabetes mellitus: a systematic review and meta-analysis of prospective cohort studies
Clinical Nutrition. https://doi.org/10.1016/j.clnu.2021.03.037

Background
No earlier systematic review and meta-analysis have been done on the association between maternal serum vitamin D status and risk of GDM among prospective studies. The current study was done to systematically review prospective cohort studies (with several years of follow-up) on the association between maternal serum vitamin D deficiency or insufficiency and risk of GDM.

Methods
Relevant papers published up to January 2020 were searched through PubMed, MEDLINE, SCOPUS, EMBASE, and Google Scholar using suitable keywords. All prospective cohort studies reporting Hazard Ratios (HRs) or Relative Risks (RRs) and 95% Confidence Intervals (CI) for GDM across categories of maternal serum vitamin D status were included.

Results
A total of 29 prospective and nested case-control studies were included in the current systematic review, of which 27 studies had sufficient data for the meta-analysis. Individuals with vitamin D deficiency had a 26% greater risk of developing GDM than those with normal serum vitamin D concentrations (OR: 1.26; 95% CI: 1.13, 1.41).
In addition, a significant positive association was seen between combined vitamin D insufficiency and deficiency and risk of developing GDM (OR: 1.23; 95% CI: 1.11, 1.35). Dose-response analysis showed a significant U-shaped non-linear association between serum vitamin D concentrations and risk of developing GDM (P<0.001), such that those with serum vitamin D concentrations between 40 and 90 nmol/L had significantly reduced risk of GDM.

Conclusions
We found a significant association between vitamin D deficiency and an increased risk of GDM. The lowest risk of GDM was found among those with a serum vitamin D levels of 40-90 nmol/L. Further studies, including randomized clinical trials, are needed to confirm our findings.


VitaminDWiki with GESTATIONAL DIABETES in title (36 as of July 2022)

This list is automatically updated

Items found: 38
Title Modified
Gestational Diabetes Mellitus 10X more-likely if low vitamin D in first trimester – July 2022 07 Aug, 2022
Gestational Diabetes 2.1 X more likely if less than 30 ng of Vitamin D - July 2022 14 Jul, 2022
Gestational diabetes risk reduced 1.5X by Vitamin D – meta-analysis March 2021 14 Jul, 2022
Vitamin D reduces preeclampsia, gestational diabetes and hypertension - 38th meta-analysis Dec 2021 31 May, 2022
Gestational Diabetes – increased risk if poor Vitamin D Receptor – 2 Meta-Analyses 2021 14 Dec, 2021
Vitamin D reduces pre-eclampsia, gestational diabetes and hypertension - 38th meta-analysis Dec 2021 05 Dec, 2021
50,000 IU of Vitamin D every 2 weeks reduced gestational diabetes – RCT Feb 2015 15 Aug, 2020
300,000 IU injection loading dose of vitamin D3 stopped gestational diabetes in RCT – Oct 2011 25 Jul, 2020
Vitamin D cuts pregnancy risks in half – low birth weight, preeclampsia, gestational diabetes – Cochrane July 2019 12 Sep, 2019
Gestational Diabetes 2.4X more likely if poor Vitamin D Receptor (region in China) – June 2019 24 Jun, 2019
Vitamin D food fortification during pregnancy reduced gestational diabetes in daughters by 13 percent – Nov 2018 14 Jun, 2019
Gestational Diabetes 3 X more likely if poor Vitamin D receptor (Turkey) – May 2019 18 May, 2019
Gestational diabetes 60 percent more likely below 20 ng of vitamin D – meta-analysis Feb 2012 23 Mar, 2019
Vitamin D treats Gestational Diabetes, decreases hospitalization and newborn complications – meta-analysis March 2019 23 Mar, 2019
Gestational Diabetes 39 percent more likely if insufficient Vitamin D – Meta-analysis March 2018 17 Mar, 2018
Gestational Diabetes Mellitus 1.5X more likely if low vitamin D – meta-analysis Oct 2015 07 Feb, 2018
Gestational diabetes treated by Vitamin D plus Omega-3 – RCT Feb 2017 02 Jan, 2018
Gestational Diabetes increasing, especially in dark skinned women (low vitamin D) - 2007 30 Dec, 2017
Gestational Diabetes 1.9 X more likely if low vitamin D – review Dec 2017 15 Dec, 2017
Congenital Heart Disease is associated with gestational diabetes in first trimester (need Vitamin D and Omega-3 early) Dec 2017 15 Dec, 2017
Vitamin D Receptor is associated with preeclampsia, gestational diabetes and preterm birth – Nov 2017 10 Nov, 2017
Gestational Diabetes Mellitus associated with 4 Vitamin D genes – Oct 2015 09 Nov, 2017
Gestational diabetes 30 percent less likely if consumed more than 400 IU of vitamin D daily – Oct 2017 04 Oct, 2017
Low vitamin D plus gestational diabetes resulted in increased ICU use, SGA – Oct 2016 07 Jun, 2017
Gestational Diabetes 3.7 X more likely if smoke and have low vitamin D (no surprise) – Feb 2016 04 Jan, 2017
Gestational Diabetes reduce 3 times by 5,000 IU of Vitamin D – RCT Jan 2016 10 Dec, 2016
Gestational Diabetes reduced with 50,000 IU of vitamin D every 3 weeks and daily Calcium – RCT June 2014 03 Sep, 2016
Gestational Diabetes treated with 50,000 IU every two weeks – RCT Sept 2016 03 Sep, 2016
Infant much healthier if Gestational Diabetic mother got 2 doses of vitamin D – RCT Nov 2014 09 Apr, 2016
Gestational Diabetes helped by Vitamin D and Calcium (also less C-section and LGA) – RCT Jan 2016 16 Jan, 2016
Gestational diabetes – Vitamin D and Calcium provided huge benefits – RCT March 2015 13 Jan, 2016
Gestational diabetes reduced by just two 50,000 IU doses of vitamin D – RCT Nov 2014 02 Oct, 2015
Increased Gestational Diabetes and poorer infant health associated with low vitamin D – June 2015 01 Jul, 2015
Gestational Diabetes in 10 percent of pregnancies, vitamin D probably helps – Jan 2014 14 Apr, 2015
Gestational Diabetes reduced 40 percent by 5,000 IU of vitamin D – RCT April 2014 02 Mar, 2015
Gestational Diabetes mostly treated with just 2 doses of 50,000 IU of vitamin D – RCT Dec 2013 26 Jun, 2014
Will 1600 IU vitamin D prevent gestational diabetes – no, not enough, July 2013 31 Aug, 2013
Gestational diabetes 2.2X more likely below 10 ng of vitamin D – June 2012 15 Nov, 2012


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