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Diabetics helped by vitamin D in 5 ways – meta-analysis June 2018

The Effects of Vitamin D Supplementation on Biomarkers of Inflammation and Oxidative Stress in Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Horm Metab Res. 2018 Jun;50(6):429-440. doi: 10.1055/a-0630-1303. Epub 2018 Jun 8.
Mansournia MA1, Ostadmohammadi V2, Doosti-Irani A3,4, Ghayour-Mobarhan M5, Ferns G6, Akbari H7, Ghaderi A8, Talari HR9, Asemi Z2.

VitaminDWiki

Overview Diabetes and vitamin D contains the following summary

  • Diabetes is 5X more frequent far from the equator
  • Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
  • Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
  • Sedentary people get less sun / Vitamin D
  • Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
  • Elderly get 4X less vitamin D from the same amount of sun
        Elderly also spend less time outdoors and have more clothes on
  • All items in category Diabetes and Vitamin D 379 items: both Type 1 and Type 2

Vitamin D appears to both prevent and treat diabetes

  • Appears that >2,000 IU will Prevent
  • Appears that >4,000 IU will Treat , but not cure
  • Appears that Calcium and Magnesium are needed for both Prevention and Treatment
        which are just some of the vitamin D cofactors

Diabetes category starts with the following

379 items In Diabetes category

see also Overview Diabetes and vitamin D  Overview Metabolic Syndrome and vitamin D

Autoimmune category listing has 115 items along with related searches

T1 diabetes OR type1 diabetes in title 107 as of April 2018
prediabetes OR prediabetic 336 items as of Jan 2018
Search VitaminDWiki for Peripheral Neuropathy 238 items April 2018


Pages listed in BOTH of the categories Diabetes and Meta-analysis


Many studies have found that vitamin D treats diabetes, especially when it can get past poor guts

Pages listed in BOTH of the categories Diabetes and Intervention

PDF is available free at Sci-Hub

In this systematic review and meta-analysis of randomized controlled trials (RCTs), the effects of vitamin D supplementation on biomarkers of inflammation and oxidative stress in diabetic patients are summarized. The following databases were searched up to December 2017: MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials. The quality of the relevant extracted data was assessed according to the Cochrane risk of bias tool. Data were pooled using the inverse variance method and expressed as mean difference with 95% Confidence Intervals (95% CI). Heterogeneity between studies was assessed by the Cochran Q statistic and I-squared tests (I2).

Overall, 33 studies were included in the meta-analyses. Vitamin D supplementation were found to significantly reduce

  • serum high-sensitivity C-reactive protein (hs-CRP) (WMD 0.27; 95% CI, - 0.35, - 0.20; p<0.001) and
  • malondialdehyde (MDA) levels (WMD - 0.43, 95% CI - 0.62, - 0.25, p<0.001)

in diabetic patients. In addition, vitamin D supplementation were found to increase

  • markers of nitric oxide (NO) release (WMD 4.33, 95% CI 0.96, 7.70),
  • total serum antioxidant capacity (TAC) (WMD 57.34, 95% CI 33.48, 81.20, p<0.001) and
  • total glutathione (GSH) levels (WMD 82.59, 95% CI 44.37, 120.81, p<0.001).

Overall, this meta-analysis shows that in diabetic patients, taking vitamin D had significant effects on hs-CRP and MDA levels, and significantly increased NO, TAC and GSH levels.
T2DM
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NO increased in diabetics ( a good thing)
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Created by admin. Last Modification: Saturday June 23, 2018 18:22:28 UTC by admin. (Version 6)

Attached files

ID Name Comment Uploaded Size Downloads
9950 NO.jpg admin 14 Jun, 2018 12:17 38.43 Kb 44
9949 T2DM.jpg admin 14 Jun, 2018 12:17 56.40 Kb 46
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