Loading...
 
Toggle Health Problems and D

T1 Diabetes increased by 27% by second year of COVID – meta-analysis June 2023


Incidence of Diabetes in Children and Adolescents During the COVID-19 Pandemic – A Systematic Review and Meta-Analysis

JAMA Netw Open. 2023;6(6):e2321281. doi:10.1001/jamanetworkopen.2023.21281
Daniel D’Souza, BHSc1; Jessica Empringham, MD2; Petros Pechlivanoglou, PhD1,3; et alElizabeth M. Uleryk, MLS4; Eyal Cohen, MD, MSc1,2,3,5; Rayzel Shulman, MD, PhD1,2,3,6

Image
Key Points

  • Question Was there a change in the incidence of diabetes in children and adolescents after the onset of the COVID-19 pandemic?
  • Findings In this systematic review and meta-analysis of 42 studies including 102 984 youths, the incidence of type 1 diabetes was higher during the COVID-19 pandemic compared with before the pandemic.
  • Meaning The findings suggest the need to elucidate possible underlying mechanisms to explain temporal changes and increased resources and support for the growing number of children and adolescents with diabetes.

Importance There are reports of increasing incidence of pediatric diabetes since the onset of the COVID-19 pandemic. Given the limitations of individual studies that examine this association, it is important to synthesize estimates of changes in incidence rates.

Objective To compare the incidence rates of pediatric diabetes during and before the COVID-19 pandemic.

Data Sources In this systematic review and meta-analysis, electronic databases, including Medline, Embase, the Cochrane database, Scopus, and Web of Science, and the gray literature were searched between January 1, 2020, and March 28, 2023, using subject headings and text word terms related to COVID-19, diabetes, and diabetic ketoacidosis (DKA).

Study Selection Studies were independently assessed by 2 reviewers and included if they reported differences in incident diabetes cases during vs before the pandemic in youths younger than 19 years, had a minimum observation period of 12 months during and 12 months before the pandemic, and were published in English.

Data Extraction and Synthesis From records that underwent full-text review, 2 reviewers independently abstracted data and assessed the risk of bias. The Meta-analysis of Observational Studies in Epidemiology (MOOSE) reporting guideline was followed. Eligible studies were included in the meta-analysis and analyzed with a common and random-effects analysis. Studies not included in the meta-analysis were summarized descriptively.

Main Outcomes and Measures The primary outcome was change in the incidence rate of pediatric diabetes during vs before the COVID-19 pandemic. The secondary outcome was change in the incidence rate of DKA among youths with new-onset diabetes during the pandemic.

Results Forty-two studies including 102 984 incident diabetes cases were included in the systematic review. The meta-analysis of type 1 diabetes incidence rates included 17 studies of 38 149 youths and showed a higher incidence rate during the first year of the pandemic compared with the prepandemic period (incidence rate ratio [IRR], 1.14; 95% CI, 1.08-1.21). There was an increased incidence of diabetes during months 13 to 24 of the pandemic compared with the prepandemic period (IRR, 1.27; 95% CI, 1.18-1.37). Ten studies (23.8%) reported incident type 2 diabetes cases in both periods. These studies did not report incidence rates, so results were not pooled. Fifteen studies (35.7%) reported DKA incidence and found a higher rate during the pandemic compared with before the pandemic (IRR, 1.26; 95% CI, 1.17-1.36).

Conclusions and Relevance This study found that incidence rates of type 1 diabetes and DKA at diabetes onset in children and adolescents were higher after the start of the COVID-19 pandemic than before the pandemic. Increased resources and support may be needed for the growing number of children and adolescents with diabetes. Future studies are needed to assess whether this trend persists and may help elucidate possible underlying mechanisms to explain temporal changes.
 Download the PDF from VitaminDWiki


Many might have to have daily insulin for life - Dr. Campbell Substack and YouTube

Substack -lots of text

YouTube July 4, 2023 20 minutes


VitaminDWiki - 12 studies in both categories Diabetes and Virus

This list is automatically updated


VitaminDWiki – Overview Diabetes and vitamin D contains

  • Diabetes is 5X more frequent far from the equator
  • Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
  • Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
  • Sedentary people get less sun / Vitamin D
  • Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
  • Elderly get 4X less vitamin D from the same amount of sun
        Elderly also spend less time outdoors and have more clothes on
  • All items in category Diabetes and Vitamin D 535 items: both Type 1 and Type 2

Vitamin D appears to both prevent and treat diabetes

Number of articles in both categories of Diabetes and:
'This list is automatically updated''

  • Dark Skin 24;   Intervention 56;   Meta-analysis 38;   Obesity 35;  Pregnancy 44;   T1 (child) 39;  Omega-3 11;  Vitamin D Receptor 24;  Genetics 12;  Magnesium 27    Click here to see details

Some Diabetes studies

50 ng of Vitamin D fights Diabetes

T1 Diabetes

Pre-Diabetes

Diabetes, Metabolic Syndrome and Magnesium - many studies


65+ VitaminDWiki Diabetes pages with T1 or TYPE 1 in title

This list is automatically updated

Items found: 69
Title Modified
Many T1 Diabetics in Finland are self-treating with more than 1200 IU of vitamin D daily – Feb 2024 15 Feb, 2024
Many T1 Diabetics in Finland are self-treating with more than 1200 IU of vitamin D daily – Feb 2024 15 Feb, 2024
Men with 20 years of type 1 Diabetes have the same vitamin D levels as controls - Dec 2023 18 Dec, 2023
FDA drug to TREAT child Type 2 diabetes (based on 1 trial of only 50) – June 2023 10 Nov, 2023
T1 Diabetes increased by 27% by second year of COVID – meta-analysis June 2023 01 Jul, 2023
T1 Diabetic adults 5X more likely to get COVID (hint low vitamin D)– Nov 2022 24 Nov, 2022
Milk Consumption Is strongly linked to Type 1 Diabetes – Dr. Greger Nov 2019 14 Nov, 2022
T1 Diabetes in child not prevented by a tiny amount of vitamin D during pregnancy – Nov 2015 15 Oct, 2022
Increased Phosphorus increases Vitamin D getting to cells (CYP24A1, pigs) - Aug 2022 25 Aug, 2022
T1 Diabetes 6.5 X more likely in South African Blacks if poor Vitamin D Binding Protein – July 2022 18 Jul, 2022
Diabetes: 1 in 10 people have it, but half do not know it – Nov 2019 14 Mar, 2022
Prevent half of T1 Diabetes with vitamin D levels of 50 ng – Dec 2012 04 Jan, 2022
Vitamin D2 not help – again ( T1 diabetes– which has been helped by D3) – Jan 2022 17 Dec, 2021
Diabetes - 1 in 10 adults, 966 billion dollar cost in 2021 12 Dec, 2021
Somewhat less Type 1 Diabetes in Wales recently – perhaps more sun or more vitamin D – March 2021 13 Mar, 2021
Little Vitamin D benefit if not achieve a good level (T1D in this cases) – Jan 2021 26 Feb, 2021
Endocrine Disrupting Chemicals and Vitamin D (T1 Diabetes in this case) - April 2020 12 Feb, 2021
Type 1 Diabetes (Autoimmune) and Vitamin D, Vitamin D Receptor and Cathelicidin - Dec 2020 03 Dec, 2020
T1 Diabetes 3X lower risk if high vitamin D (over 40 ng) – Meta-analysis Nov 2020 30 Nov, 2020
Poor CYP2R1 gene results in lower vitamin D and 2X increase in T1 Diabetes – Sept 2019 16 May, 2020
Fasting and Diabetes both reduce Vitamin D activation (CYP2R1 in rodents) – May 2019 19 Nov, 2019
T1 Diabetes treated by Vitamin D and Omega-3 (many other studies agree) Jan 2018 23 Oct, 2019
Children in India – 1 in 7 extremely low Vitamin D, 1 in 10 prediabetic – Sept 2019 10 Oct, 2019
Type II diabetes 2 X more likely if poor Vitamin D Gene (CYP27B1) – Oct 2019 07 Oct, 2019
Type 1 diabetes trial having problems getting participants – too many taking Vitamin D or Omega-3 – Aug 2019 03 Oct, 2019
Type 1 Diabetes is prevented and treated by Vitamin D – review of 16 studies – Sept 2019 14 Sep, 2019
T1 Diabetes reduction by high Omega-3 and Vitamin D – GRH ongoing observation 12 Sep, 2019
Type 1 Diabetes prevention with Vitamin D and Omega-3 – Symposium April 2019 25 Apr, 2019
Type 1 Diabetes risk increased if high postpartum Vitamin D binding protein – Jan 2019 24 Mar, 2019
T1 Diabetes – how it may be prevented and treated by Vitamin D – Dec 2018 29 Dec, 2018
Vitamin D and Omega-3 may treat Type 1 Diabetes – RCT 2024 24 Nov, 2018
Type 1 Diabetes is increasing – decreased vitamin D is one of the many possible reasons – Sept 2018 02 Nov, 2018
Type 1 diabetes 1.6 times more likely if a Vitamin D Receptor problem – Feb 2017 21 Aug, 2018
Early Type 1 Diabetes May Shorten Women’s Lives by 18 Years - Aug 2018 17 Aug, 2018
HbA1c levels (Diabetes) reduced by monthly 50,000 IU of vitamin D – Dec 2017 01 Mar, 2018
Prediabetes corrected in 3 months by 1,000 IU of vitamin D as pill or in yogurt – RCT Jan 2018 29 Jan, 2018
5 Antibiotic courses raised risk of diabetes by 37 percent (200,000 diabetics, more than 1 year after antibiotic) - 2015, 2016 24 Jan, 2018
Type 1 Diabetes (T1DM) 1.6 X more likely if low vitamin D – meta-analysis Jan 2018 20 Jan, 2018
Type 1 Diabetes 14 percent more likely with 2 Vitamin D Receptor mutations – Oct 2017 12 Nov, 2017
Type 1 diabetes helped with 50,000 IU of vitamin D every two weeks – Nov 2014 20 Jul, 2017
T1 Diabetes associated with many other autoimmune diseases (all related to low vitamin D) – May 2017 03 Jun, 2017
Off topic: Insulin spike cut in half if take 1 tablespoon of extra virgin olive oil with meal – RCT June 2017 31 May, 2017
Type 1 Diabetes association with poor Vitamin D Receptor: 39 studies – April 2017 20 Apr, 2017
Type 1 diabetes associated with faulty Vitamin D receptor genes – May 2013 20 Apr, 2017
Type 1 diabetes, genes and vitamin D 20 Apr, 2017
Type 1 diabetes risk not decreased if add 400 IU vitamin D while pregnant (no surprise) – Dec 2016 13 Dec, 2016
Diabetes (Type 1) increasing 4 percent per year, now 30,000 in the UK - May 2015 05 May, 2016
T1 diabetes in children helped with two doses of 150,000 IU of vitamin D and Calcium – March 2015 16 Nov, 2015
T1 Diabetes 35 percent more likely if 10 degrees further from equator (less vitamin D) – June 2014 16 Nov, 2015
Type 1 diabetes 3.5X more frequent if low vitamin D - Medscape CME Dec 2012 16 Nov, 2015
Type 1 Diabetes probability reduced by 2X if have more than 40 ng of vitamin D – Feb 2013 16 Nov, 2015
T1 Diabetes associated with low vitamin D - Nov 2014 16 Nov, 2015
1 night without sleep affects insulin resistance as much as 6 months of high fat diet (vitamin D not mentioned) – Nov 2015 05 Nov, 2015
Diabetes (Type 1) 14X more likely in dark skin children with low levels of vitamin D – May 2015 28 May, 2015
1 in 10 Chinese adults are diabetics and 15 percent prediabetic - Mar 2010 06 Mar, 2015
Type 1 diabetes strongly associated with low vitamin D – March 2013 06 Dec, 2014
Type 1 Diabetes associated with low vitamin D, especially in dark skinned youths – Dec 2012 06 Dec, 2014
Diabetes: Type 1 and 2 known for since 500 AD, Type 1.5 (LADA) known since 1993 22 Aug, 2014
Type 1 diabetes starting to decrease in Finland, they started Vitamin D fortification in 2003 – July 2013 26 Jul, 2014
T1 Diabetes increased about 15 percent per decade in Eastern Canada – Oct 2012 14 Jun, 2014
Type 1 diabetes is increasing, vitamin D deficiency may be one of the reasons – Aug 2013 14 Jun, 2014
T1DM, toll-like receptors and vitamin D in rats – May 2014 21 May, 2014
Type 1 diabetes patients may be pissing away vitamin D – Jan 2011 14 May, 2014
T1 Diabetes independent of vitamin D for levels (disagrees with other studies) – Sept 2013 14 Sep, 2013
44 percent less Type 1 diabetes if high level of vitamin D – white skinned military – March 2013 13 Apr, 2013
Type 1 diabetes epidemic not correlated with vitamin D in womb – Aug 2011 15 Feb, 2012
Vitamin D deficient Type 1 diabetics 3X more likely to have calcification problems – Feb 2011 28 Oct, 2011
4000 IU vitamin D improved glycemic control for type 1 diabetes – Nov 2010 11 Nov, 2010
US Diabetics currently 1 in 10 may increase to 1 in 5 or 1 in 3 by 2050 – Oct 2010 23 Oct, 2010

This increase in T1 may be due to COVID's deactivation of Vitamin D Receptor

COVID protects itself by deactivation of the VDR.
COVID probably fails to re-activate the VDR when it leave the body


VitaminDwiki COVID infections and vaccinations decrease Vitamin D – many studies

Vaccination

Vaccination and/or Infection

Hypothesis: The body consumes Vitamin D each time the immune system is activated
Image
The "GREEN" person started with a high level of Vitamin D
This assumes no vitamin D supplementation by supplements, sun, etc.


See also web

  • Could the development of COVID-19 vaccine-induced type 1 diabetes be explained by a simple mechanism? - july 2022 -doi: 10.1016/j.diabet.2022.101338 FREE PDF
  • Vaccine-induced autoimmunity: the role of molecular mimicry and immune crossreaction - June 2018 https://doi.org/10.1038/cmi.2017.151 FREE PDF
  • Vaccines and the risk of insulin-dependent diabetes (IDDM): potential mechanism of action - Nov 2001 DOI: 10.1054/mehy.2001.1352 FREE PDF

Attached files

ID Name Comment Uploaded Size Downloads
19724 T1D COVID.jpg admin 01 Jul, 2023 35.41 Kb 122
19723 T1D COVID_CompressPdf.pdf admin 01 Jul, 2023 163.27 Kb 56