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Lyme disease appears to massively deactivate the Vitamin D Receptor - 2019

Lyme disease reduced Vitamin D Receptor by 8X to 50X - June 2019

Vitamin D Receptor - activation and deactivation- self-hacked June 2019

  • Lyme/Borrelia – Live Borrelia reduces VDR by 50 times (in monocytes) and “dead” Borrelia reduces it by 8 times 63
    • This could explain why people develop autoimmune conditions after Lyme infection.

Chronic Lyme disease - Feb 2019

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Borrelia and the VDR
In the arms race of host–microbe co-evolution, successful microbial pathogens have evolved ingenious ways to evade host immune responses.9)

Studies have indicated that the dysregulation of VDR may lead to exaggerated inflammatory responses, raising the possibility that defects in Vitamin D and VDR signaling transduction may be linked to bacterial infection and chronic inflammation. Further characterization of Vitamin D/VDR will help elucidate the pathogenesis of various human diseases and in the design of new approaches for prevention and treatment. Jun Sun 10)

Since the VDR is at the heart of the innate immune system, bacteria can survive by discovering how to disable it through a variety of different actions. Actions accumulate and are more powerful than individual actions. In keeping with evolutionary theory, a growing number of substances and species have been shown to downregulate the activity of the VDR, one of which is Borrelia burgdorferi. Live Borrelia burgdorferi reduced VDR expression in monocytes (phagocytes) by 50 times, and lysates (“dead” Borrelia) reduced it by 8 times 11)

  • 8) Human Tick-Borne Diseases in Australia., Dehhaghi M, Kazemi Shariat Panahi H, Holmes EC, Hudson BJ, Schloeffel R, Guillemin GJ, Front Cell Infect Microbiol9p3(2019)
  • 9) Microbial manipulation of receptor crosstalk in innate immunity. Hajishengallis G, Lambris JD, Nat Rev Immunol11p187-200(2011 Mar)
  • 10) Vitamin D and mucosal immune function. Sun J, Curr Opin Gastroenterolp(2010 Jul 15)  Download the PDF from VitaminDWiki
  • 11) Activation of human monocytes by live Borrelia burgdorferi generates TLR2-dependent and -independent responses which include induction of IFN-beta. Salazar JC, Duhnam-Ems S, La Vake C, Cruz AR, Moore MW, Caimano MJ, Velez-Climent L, Shupe J, Krueger W, Radolf JD, PLoS Pathog5pe1000444 (2009 May)  Download the PDF from VitaminDWiki

Comment by the founder of VitaminDWiki

Various cancers have been documented to reduce the amount of vitamin D in the tissues (not in the blood) by deactivating the Vitamin D receptor. Lyme disease may be another disease which has learned the protection trick. A Vitamin D Receptor with poor activation is not detectable by any standard vitamin D test. Thus a person with Lyme disease could have a good blood level of vitamin D but a poor tissue level of vitamin D. There are many ways to restore the activation of the Vitamin D receptor - see below

Vitamin D Receptor category has the following

410 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population have a poor VDR (40% of the Obese )

A poor VDR increases the risk of 55 health problems  click here for details
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

Compensate for poor VDR by increasing one or more:

1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D in the cells
13) Sulfroaphane and perhaps sulfurVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR

Vitamin D Receptor and various Cancers

Items in both categories Vitamin D Receptor and Cancer - Breast:

Items in both categories Vitamin D Receptor and Cancer - Colon:

Items in both categories Vitamin D Receptor and Cancer

Items in both categories Vitamin D Receptor and Cancer - other:

Items in both categories Vitamin D Receptor and Cancer - Skin:

Items in both categories Vitamin D Receptor and Cancer - Prostate:

Items in both categories Vitamin D Receptor and Cancer - Ovarian:

See also: Lyme and Vitamin D on the web

Lyme Disease rate increased 4X in 28 years

Possible reasons for increase include:
- lower D in population,
- increasing rate of poor Vitamin D Receptor,
- warmer climate
- more ticks

Lyme Disease Is Baffling, Even to Experts

Atlantic Aug 2019
Took 16 years to get her problem correctly diagnosed

  • "Reported cases increased almost fivefold from 1992 to 2017, and the Centers for Disease Control and Prevention estimates that annual incidences have risen to more than 300,000, and may even range above 400,000"
  • "After 40 years in the public-health spotlight, Lyme disease still can’t be prevented by a vaccine; eludes reliable testing; and continues to pit patients against doctors, and researchers against one another."
  • "A significant percentage of people who had Lyme symptoms and later tested positive for the disease had never gotten the rash. Others had many characteristic symptoms but tested negative for the infection, and entered treatment anyway. Most startling, a portion of patients who had been promptly and conclusively diagnosed with Lyme disease and treated with the standard course of doxycycline didn’t really get better."

Lyme Disease Map 2015

It's Time to Get Serious about Tick-Borne Diseases - Scientific American Aug 2019

Scientific American Vitamin D NOT mentioned

  • "Today another epidemic rages unchecked: the number of Lyme disease cases has doubled since 2004, for a total of over 400,000."
  • "At least 10 to 20 percent stay sick for a year, with 5 percent still suffering 15 years later—this among patients receiving early treatment, who have the best outcomes"
  • 67 Lyme Disease Clinical trials as of 2019
  • "In 2017, mosquito-borne West Nile virus, which currently infects about 2,000 people annually in the U.S. received $42 million in support from the U.S. National Institutes of Health. Lyme disease, with 20 times the number of reported cases, got half as much, a figure that has changed little in a decade"

Created by admin. Last Modification: Tuesday August 20, 2019 14:57:50 GMT-0000 by admin. (Version 21)

Attached files

ID Name Comment Uploaded Size Downloads
12468 Lyme Disease 2015.jpg admin 14 Aug, 2019 13:14 34.18 Kb 5234
12331 Lyme reports.jpg admin 15 Jul, 2019 16:00 73.35 Kb 5712
12092 Activation of Human Monocytes by Live Borrelia burgdorferi .PDF admin 07 Jun, 2019 17:32 1.90 Mb 368
12091 nihms355251.pdf admin 07 Jun, 2019 17:22 763.22 Kb 339
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