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Fertility and sperm

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116 items in Fertility or Sperm in VitaminDWiki

See also

Overview Women and Vitamin D
Overview Pregnancy and vitamin D    Fertility and Vitamin D – several articles
Endometriosis
Ensure a healthy pregnancy and baby - take Vitamin D before conception
Search VitaminDWiki for IVF OR "IN VITRO FERTILIZATION" 345 items as of Sept 2019
Search VitaminDWiki for "Assisted reproduction" 177 items as of Sept 2019
Search VitaminDWiki for "polycystic ovary syndrome" OR PCOS" Sept 2019
Search VitaminDWiki fore Testosterone 77 items just in webpages as of Sept 2020
Search VitaminDWiki for "erectile dysfunction" 120 items as of July 2018
Conception and vitamin D snapshot as of 2012

Vitamin D greatly improves Fertility

Increased male Vitamin D increases fertility

Items in both of the categories Intervention AND Fertility/Sperm



600,000 IU of vitamin D a few weeks before IVF did not help - RCT April 2021

Single oral dose of vitamin D3 supplementation prior to in vitro fertilization and embryo transfer in normal weight women: the SUNDRO randomized controlled trial
American Journal of Obstetrics and Gynecology, https://doi.org/10.1016/j.ajog.2021.04.234

Background
Improving in vitro fertilization (IVF) success is an unmet need. Observational studies suggested that women with deficient or insufficient vitamin D have lower chances of success, but whether supplementation improves clinical pregnancy rate is unclear.

Objective
To determine whether oral vitamin D3 supplementation may improve clinical pregnancy in women undergoing an IVF cycle

Study design
The SUNDRO trial is a two-centers randomized superiority double-blind placebo controlled trial. Subjects were recruited between October 2016 and January 2019. Participants were women aged 18-39 years with low vitamin D (peripheral 25-hydroxyvitamin D < 30 ng/ml), serum calcium ≥ 10.6 mg/dl, body-mass index (BMI) 18-25 Kg/m2, anti-mullerian hormone (AMH) levels > 0.5 ng/ml, starting their first, second, or third treatment cycle of conventional IVF or intracytoplasmic sperm injection (ICSI). The primary outcome was the cumulative clinical pregnancy rate per cycle. Pregnancies obtained with both fresh or frozen embryo transfers were included. Clinical pregnancy was defined as intrauterine gestational sac with viable fetus. The primary analysis was performed according to the intention to treat principle and could also include natural conceptions. Secondary outcomes included total dose of gonadotropins used, embryological variables (number of oocytes retrieved, number of suitable oocytes retrieved, fertilization rate and rate of top quality embryos) and clinical outcomes (miscarriage rate and live birth rate).

Results
630 women were randomized 2-12 weeks prior to initiate the IVF cycle to receive either a single dose of 600,000 IU of vitamin D3 (n=308) or placebo (n=322). One hundred thirteen (37%) and 130 (40%) women achieved a clinical pregnancy in the treatment and placebo groups, respectively (p=0.37). The risk ratio (RR) of clinical pregnancy in women receiving vitamin D3 was 0.91 (95% confidence interval-CI: 0.75 – 1.11). Compared to placebo, vitamin D3 supplementation did not significantly improve the secondary outcomes. Exploratory subgroup analyses for BMI, age, indication to IVF, ovarian reserve, interval between drug administration and initiation of the cycle and basal levels of 25-hydroxyvitamin D failed to highlight any clinical situation that could benefit from the supplementation.

Conclusions
In normal weight women with preserved ovarian reserve and low vitamin D levels undergoing IVF cycles, a single oral dose of 600,000 IU of vitamin D3 does not improve the chances of clinical pregnancy. Although the findings do not support the use of vitamin D3 supplementation to ameliorate IVF success, further studies are required to rule out milder but potentially still interesting benefits as well as exploring the effectiveness of alternative modalities of supplementation.


Clinical trial of 50,000 IU vitamin D weekly to improve IVF success - Phase 4 trial announced July 2017

Vitamin D Supplementation in Vitamin Deficient Women Undergoing IVF Cycles: Does it Affect the Fertility Outcome?
Unfortunately trial is only giving vitamin D to the women, and for only 2 months
They will be measuring results over the next 12 months
Doubt that this clinical trial will be successful
50,000 IU bi-weekly to both man and woman during an entire year would have had far better success.


50% reduction in sperm count around the world in just 40 years - Aug 2017

Skyrocketing Male Infertility May Threaten Mankind’s Survival - Mercola

  • "According to the largest meta-analysis of its kind, sperm counts around the world declined by more than 50 percent, to 47 million sperm per mL, between 1973 and 2013, and continue to dwindle"
  • "The most significant declines were found in samples from men in North America, Europe, Australia and New Zealand, where many had sperm concentrations below 40 million/mL — a level at which a man will have trouble fertilizing an egg"
    Vitamin D was barely mentioned

Eating more fish (probably Omega-3 and Vitamin D) resulted in a 16% increase in babies - May 2018

Survey of 501 couples, New York Times
Reportingo n study in Journal of Clinical Endocrinology and Metabolism https://doi.org/10.1210/jc.2018-00385

  • "By 12 months, 92 percent of couples who ate fish twice a week or more were pregnant, compared with 79 percent among those who ate less."

IVF 2X more successful in summer (when vitamin D levels are higher) - July 2018

IVF treatment success rate doubles in summers


Men Are Freaking Out About Their Sperm NYT July 2018

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Vitamin D: Study Finds Impaired Fertility May 2016

RCT of Vitamin D and Fertility - daily for a year - to 16 weeks after birth
This data disagrees with a majority of studies on this page

Became pregnantComplications
Placebo 38%52%
1400 IU33%23% for 1400 and 2800 IU
2800 IU39%

Statistical certainty of the percentages was not given in the abstract

  • "Complications during labor, including preeclampsia and postpartum bleeding, were significantly more frequent in the placebo group compared with the combined treatment groups (52% versus 23%, P=0.005)."
  • "The study found no difference in other complications including pre-term birth, miscarriage, gestational diabetes, and infections"
  • No comment on any differences in Still Births, Death during first year, etc.
  • Wonder if mothers getting lots of vitamin D had more alive and healthy children at the one year mark compared to placebo

Abstract


Why Are Young People Having So Little Sex? Nov 2018

The Atlantic Vitamin D is not mentioned

  • "...Americans are in the midst of a sex recession"
  • "...crushing economic pressures, of surging anxiety rates, of psychological frailty, of widespread antidepressant use, of streaming television, of environmental estrogens leaked by plastics, of dropping testosterone levels, of digital porn, of the vibrator’s golden age, of dating apps, of option paralysis, of helicopter parents, of careerism, of smartphones, of the news cycle, of information overload generally, of sleep deprivation, of obesity. Name a modern blight, and someone, somewhere, is ready to blame it for messing with the modern libido?

The Disappearing Y Chromosome Atlantic Mag Dec 2019

It’s surprisingly common for men to start losing entire chromosomes from blood cells as they age

  • "Now a new study—the largest yet of this phenomenon—estimates that 20 percent of 205,011 men in a large genetic database called the UK Biobank have lost Y chromosomes from some detectable proportion of their blood. By age 70, 43.6 percent of men had the same issue."

No mention of Vitamin D


Vitamin D in human reproduction: some answers and many more questions - Jan 2021

 Download the PDF from VitaminDWiki


Less fertile mice if low Vitamin D (fully-activated Vitamin D) - Feb 2021

  • 1,25-Dihydroxyvitamin D deficiency accelerates male reproductive senescence in aging mice
    • doi: 10.1152/ajpendo.00531.2020, free abstract, study is behind $25 paywall
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10243 Fertile meta.jpg admin 25 Jul, 2018 16:54 19.10 Kb 3573
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