The association between serum vitamin D, fertility and semen quality: A systematic review and meta-analysis
International Journal of Surgery, Volume 71, November 2019, Pages 101-109, https://doi.org/10.1016/j.ijsu.2019.09.025
- In-vitro Fertilization costs at least 10,000 dollars, Vitamin D costs 5 dollars
- Vitamin D is needed for human fertility – goal is 50 ng – Sept 2018
- Male fertility 4 X higher if high Vitamin D – Nov 2015
- Infertility rate is 2X higher for blacks than whites (no mention of vitamin D, nor the man) – April 2014
- Each 1 ng increase in blood level of vitamin D increases clinical pregnancy by 6% PDF
- Fertility (sperm) associated with vitamin D – meta-analysis Sept 2019
- IVF 50 percent more likely to result in pregnancy if high vitamin D – meta-analysis Nov 2017
- Global sperm count dropped by 59 percent in 40 years – meta-analysis Aug 2017
- In vitro fertilization not helped by vitamin D if ignore high levels and male levels – meta Mar 2016
Fertility and Sperm category contains the following summary
Overview Women and Vitamin D
Overview Pregnancy and vitamin D Fertility and Vitamin D – several articles
Ensure a healthy pregnancy and baby - take Vitamin D before conception
Search VitaminDWiki for IVF OR "IN VITRO FERTILIZATION" 345 items as of Sept 2019
Search VitaminDWiki for "Assisted reproduction" 177 items as of Sept 2019
Search VitaminDWiki for "polycystic ovary syndrome" OR PCOS" Sept 2019
Search VitaminDWiki fore Testosterone 472 items as of Oct 2017
Search VitaminDWiki for "erectile dysfunction" 120 items as of July 2018
Conception and vitamin D snapshot as of 2012
Download the PDF from VitaminDWiki
Forest plot of the association between serum 25(OH)D level and fertility.
- Human infertility affects 10–15% of couples.
- Male fertility potential is clinically examined by semen analysis.
- Vitamin D (Vit D) has gained major attention in recent years.
- The findings will be used to inform public health programming and improve diet quality among men with infertility problems.
A number of studies have examined the association between vitamin D, fertility and semen quality, however, findings have been inconclusive. Herein, we systematically reviewed available observational studies to elucidate the overall relationship between vitamin D, fertility and semen quality in adult population.
PubMed, Cochrane's Library, Science Direct, Scopus, Google Scholar and ISI Web of Science databases were searched until December 2018 for all available studies evaluating the association between vitamin D, fertility and semen quality. The Newcastle-Ottawa Quality Assessment Scale was used to examine the quality of each study.
A total of 18 studies out of 1843 met our inclusion criteria and were included in our systematic review and meta-analysis. Serum 25(OH)D3 was significantly higher in fertile subjects compared to infertile ones (WMD -0.63; 95% CI, −1.06 to −0.21; P = 0.003). Furthermore, there was a significant association between serum 25(OH)D, sperm motility (WMD -5.84; 95% CI, −10.29 to −1.39; P = 0.01) and sperm progressive motility (WMD -5.24; 95% CI, −8.71 to −1.76; P = 0.003).
Our findings add to the existing literature supporting the concept that nutrition, especially vitamin D, plays an important role in men's sexual health. It should be noted that because of significant heterogeneity among the included studies, caution is warranted when interpreting the results. Further well-designed prospective cohort studies and clinical trials are needed for better understanding of the relationship between vitamin D and fertility and its components.