Scientific Journal of Gynecology and Obstetrics
E L Heyden 1 and S J Wimalawansa 2
Eugene L. Heyden, RN, Clinical Nursing (retired), Providence Sacred Heart Medical Center, Spokane, Washington, gene.heyden at gmail.com
Sunil J. WImalawansa, MD, PhD, MBA, DSc., Endocrinology & Nutrition, Cardio-Metabolic & Endocrine Institute, North Brunswick, NJ, : suniljw at hotmail.com
Study prefers 40 ng, but recommends a minimum of 30 ng
Does not appear to mention several important factors
- Get Vitamin D high as soon as possible - before conception is best
- Vitamin D helps the fertility of the man as well as the woman
- Obese need > 4,000 IU to get to the same blood level
- Various genes can restrict response of Vitamin D in the blood and the tissue
- Monthly Vitamin D may be better than daily (due to genes, less likely to forget)
- Vitamin D in oil carrier is not appropriate for ~10% of the population
- Vitamin D in powder or emulsion provides a better response, about the same price
- Omega-3 Magnesium, etc helps preganaices, infants
- and gets more Vitamin D into both the blood and tissues
Pregnancy category starts with
- see also
- Overview Pregnancy and vitamin D
- Number of articles in both categories of Pregnancy and:
25 ; Depression 19 ; Diabetes 40 ; Obesity 12 ; Hypertension 36 ; Breathing 30 ; Omega-3 33 ; Vitamin D Receptor 21
- All items in category Infant/Child
- breastfed OR breastfeeding 1920 items as of Dec 2020
- Preeclampsia in VitaminDWiki title (47 as of July 2021)
- Pre-term 368 items (not in PDF) as of Nov 2020
- "polycystic ovary syndrome" OR PCOS 303 items as of Jan 2018
- Gestational Diabetes
- c-section OR "caesarean section" (various spellings) 937 items as of Aug 2020
- postpartum depression 208 items as of Aug 2018
- Search VitaminDiiki for MISCARRIAGE OR "Spontaneous abortion" 794 as of Feb 2020
- Search VitaminDWiki for "Assisted reproduction" 33 items as of Feb 2017
- Fertility and Sperm category listing has
117 items along with related searches
- (Stunting OR “low birth weight” OR LBW) 1180 items as of June 2020
- Less labor pain if higher level of vitamin D – August 2021
- Healthy pregnancies need lots of vitamin D
- Ensure a healthy pregnancy and baby - take Vitamin D before conception
Healthy pregnancies need lots of vitamin D has the following summaryProblem
Reduces Evidence 0. Chance of not conceiving 3.4 times Observe 1. Miscarriage 2.5 times Observe 2. Pre-eclampsia 3.6 times RCT 3. Gestational Diabetes 3 times RCT 4. Good 2nd trimester sleep quality 3.5 times Observe 5. Premature birth 2 times RCT 6. C-section - unplanned 1.6 times Observe Stillbirth - OMEGA-3 4 times RCT - Omega-3 7. Depression AFTER pregnancy 1.4 times RCT 8. Small for Gestational Age 1.6 times meta-analysis 9. Infant height, weight, head size
within normal limits
RCT 10. Childhood Wheezing 1.3 times RCT 11. Additional child is Autistic 4 times Intervention 12.Young adult Multiple Sclerosis 1.9 times Observe 13. Preeclampsia in young adult 3.5 times RCT 14. Good motor skills @ age 3 1.4 times Observe 15. Childhood Mite allergy 5 times RCT 16. Childhood Respiratory Tract visits 2.5 times RCT
RCT = Randomized Controlled Trial
Table of contents
- Reproductive Consequences of Vitamin D Deficiency
Background: Vitamin D deficiency during pregnancy is common and threatens the woman and her developing fetus. As a pregnancy progresses, the requirements for vitamin D increase, thus, increasing the risk of hypovitaminosis D. Consequently, the majority of women become or remain vitamin D deficient and remain vitamin D deficient during pregnancy and the postnatal period.
Rationale/Objectives: Despite some awareness of the problem, in a high percentage of pregnancies, vitamin D deficiency remains unidentified and unaddressed. Consequently, this review explores the risks and complications associated with vitamin D during pregnancy and highlights the importance of having physiological levels of serum 25-hydroxy vitamin D [25(OH)D] during pregnancy to minimize risks to mothers and fetuses.
Outcomes: Hypovitaminosis D during pregnancy leads to an increased incidence of a variety of pregnancy-related complications leading to adverse reproductive outcomes. These include higher incidences of pregnancy loss, preeclampsia, placental insufficiency, gestational diabetes, impaired immune tolerance, increased risk for cesarean delivery, bacterial vaginosis, impaired fetal growth and development, small-for-date neonates, and premature deliveries. In addition, the effects of maternal vitamin D deficiency on the fetus may continue beyond delivery.
Wider implications: There are clear medical as well as ethical reasons for clinicians to diagnose and treat vitamin D deficiency during pregnancy. Given that lives and otherwise uncomplicated pregnancies are at stake, identifying and effectively addressing vitamin D deficiency during pregnancy is not optional but essential.
The active form of vitamin D, 1,25(OH)2D, is a secosteroid hormone, intimately involved in a multitude of genomic and nongenomic effects. These effects expand from facilitating fertilization and implantation to issues related to fetal well-being . Vitamin D maintains the health of all reproductive tissues, including the endometrium , and encourages fertilization  as well as immune neutrality in the event of implantation .
Deficiency of vitamin D (hypovitaminosis D), increases the incidence and severity of many pregnancy-associated risks and complications, leading to negative outcomes. Therefore, early identification and correction of vitamin D deficiency is essential , ideally, before a women becomes pregnant. However, many pregnancies, if not most, are allowed to continue under the shadow of hypovitaminosis D; this is not uncommon in both industrialized and agricultural countries.
Vitamin D is created following exposure to ultraviolet B (UVB) radiation in the dermis and epidermis, effecting a conformational change in a 7-dehydro-cholesterol to become 9,10-secosterol, previtamin D3 . Previtamin D enters the circulation bound to vitamin D binding protein (DBP) and is transported to the liver, where it is hydroxylated to become 25(OH)D in the parenchymal cells. This precursor undergoes further modification in the renal tubular cells with 1a-hydroxylation to form active vitamin D, 1,25(OH)2D .
The transformation of vitamin D to 25(OH)D and 1,25(OH)2D customarily occurs through the actions of specific cytochrome P450 (CYP) enzymes located within renal mitochondria: CYP27A1, CYP27B1, and CYP24A1 . A number of tissues containing target cells also possess the intracellular enzymatic mechanisms to convert 25(OH)D to its hormonally active form 1,25(OH)2D, calcitriol [6, 8]. Apart from UVB exposure, small quantities of vitamin D are obtainable by diet and supplementation as D3 and D2. D3 is of animal origin, whereas D2 is derived from plant and fungi sources. Because of its longer half-life, vitamin D3 is considered more effective than D2 in maintaining physiologically healthy 25(OH)D levels [7, 9].
The terminology of “insufficiency” and “deficiency” is arbitrary. Neither vitamin D insufficiency nor deficiency is physiological, because with either condition, the biological needs of vitamin D in humans are not met. Various organs and tissues require different concentrations of 25(OH)D in serum to function optimally. Because negative reproductive outcomes occur when serum 25(OH)D levels fall within the insufficiency range, hypovitaminosis D should be identified and not allowed to persist in pregnant and pre-pregnant women .
For optimal pregnancy-related outcomes, it is recommended that serum 25(OH)D concentrations be maintained above 40 ng/mL [11, 12]. Vitamin D deficiency negatively affects the pregnant woman and the fetus in a variety of ways [13-15], including prevention of infections . Evidence supports having serum 25(OH)D concentrations between 40 and 60 ng/mL; this is achievable by daily supplementation of vitamin D on the order of 4,000 IU/day (range 3000 to 6000 IU/day) of vitamin D3 [17-19]. However, there are a handful of studies that disagree with the above findings .
Current recommendations for vitamin D supplementation during pregnancy are insufficient .
A more favorable response was reported when pregnant women were supplemented with 4,000 IU/day of vitamin D, starting in the 12 th to 16th week and continuing to completion of pregnancy, compared with doses of less than 800 IU/day .
This study and others suggest studies of vitamin D during pregnancy strongly support that the minimal vitamin D level for optimal outcomes during pregnancy is 40 ng/mL. The goal of supplementation with 4,000 IU/day for pregnant women is to increase the serum 25(OH)D levels to near or above 40 ng/mL in most women during pregnancy .
However, in 2010, the Institute of Medicine (IOM) issued guidelines for vitamin D supplementation suggesting an intake of 600 IU/day is adequate for adults regardless of their circumstances; yet, this is substantially below the physiological needs of pregnancy that have been shown to prevent complications and protect the fetus . Such intake is far from adequate to maintain the serum 25(OH)D levels needed for a healthy pregnancy and favorable reproductive outcomes [13,22].
The IOM defined vitamin D insufficiency as a value between 10 and 19 ng/mL, and severe vitamin D deficiency is defined as a value below 10 ng/mL . It should be noted that the IOM cutoff value of below 20 ng/mL for vitamin D insufficiency was based on requirements for bone health only (Endocrine Society recommendations; ). Therefore, applying the IOM recommendations to the requirements of vitamin D during pregnancy (or other diseases or conditions) is inappropriate and is, in fact, harmful to women during pregnancy .
Following the publication of the IOM public health recommendations, the Endocrinology Society and other societies took the initiative to defined vitamin D deficiency as any value below 20 ng/mL, with vitamin D insufficiency defined as a value between 20 and 30 ng/mL [21, 24, 25]. The authors and others believe a value of at least 30 ng/mL, and perhaps closer to 40 ng/mL, addresses the needs of pregnant women and their fetuses [17, 22]. In the absence of laboratory testing, the vitamin D status of an expectant mother remains unknown, complications are not prevented or relieved, and appropriate intervention is less likely to occur .
Estimates suggest that the incidence of maternal vitamin D deficiency is on the order of 20% to 40% ); whilst others report a prevalence of more than 60% of pregnant women . A much higher incidence of vitamin D deficiency occurs among pregnant African American and Latina American women because of higher levels of melanin in darker-skinned individuals, which is an impediment to UVB penetration and thus places a limitation on the generation of vitamin D .
In general, vitamin D works in conjunction with calcium, particularly in nongenomic activities . Active vitamin D initiates genomic and nongenomic events via a vitamin D receptor (VDR) . Unlike many other receptors, VDRs populate both cell membranes and the nuclei and are distributed ubiquitously in a variety of cell types [7, 28]. Consequently, vitamin D has pleotropic effects .
Irrespective of the economic status, ethnicity, or proximity to the equator of populations, vitamin D deficiency is an epidemic affecting virtually all countries . Not only vitamin D deficiency but also VDR abnormalities can lead to signs and symptoms of vitamin D deficiency . With respect to pregnancy, alterations in gene expression, those normally mediated and modulated by active vitamin D , can place the pregnancy in jeopardy and lead to many negative pregnancy and fetal outcomes, such as miscarriage, preeclampsia, gestational diabetes, and preterm birth .
Vitamin D deficiency before and during pregnancy causes a variety of significant negative outcomes and threatens the lives of the woman and the fetus (e.g., preeclampsia) . There are a number of threats and complications posed by maternal vitamin D deficiency for both mother and the fetus;, effectively resolving such is essential. Some of the common negative reproductive consequences secondary to vitamin D deficiency are Summarized in Figure 1 and will be briefly discussed below.
Preterm birth and other complications
Intrauterine growth restrictions
Increase risk of metabolic disorders—in adulthood
Increased risks : rickets, multiple sclerosis, autism, schizophrenia, etc.
Fertilization is facilitated by 1,25(OH)2D/ VDR-mediated nongenomic activity . Accordingly, intracellular 1,25(OH)2D raises calcium levels and increases the likelihood of sperm-egg binding; it also increases the activity of acrosine, the enzyme responsible for digesting zona pellucida of the ovum, allowing sperm to penetrate and fertilize the egg [27, 33].
After successful fertilization, immune tolerance of the fertilized ovum is essential to reproductive success [34, 35]. Active vitamin D orchestrates immune tolerance by stimulating Treg activity and shifting the Th1 cytokine profile from a pro-rejection profile to a tolerance-promoting Th2 profile [35, 36].
Placental VDR expression and its interaction with 1,25(OH)2D is a critical regulator of the growth of the placenta and fetus . Placental VDR/1,25(OH)2D interaction allows vitamin D to play key roles in regulating genes involved in early placental development , local immune suppression, and the production of vascular endothelial growth factor . In addition, pregnant women with 25(OH)D concentrations less than 20 ng/mL are reported to have suboptimal levels of placental growth factor, which may contribute to the development of preeclampsia and fetal growth restriction [34, 35, 40].
Compromised placental growth and development leads to vascular insufficiency and placental inflammation; the combination predisposes women to preeclampsia and associated negative consequences . Whereas, vitamin D adequacy is reported to play a decisive role in preventing and suppressing placental inflammation .
Multiple studies have reported that vitamin D deficiency is associated with an increased risk of preeclampsia [42-44]. A five-fold increase in preeclampsia was reported in pregnant women with a 25(OH)D level of 15.2 ng/mL compared with those with substantially higher 25(OH)D levels .
Underscoring the value of vitamin D in the prevention of preeclampsia, one study found a 27% reduction in preeclampsia risk in women who supplemented with vitamin D compared with those who did not supplement . Not to lose sight of the individual most at risk, a neonate born to a preeclamptic woman is five times more likely die during the first birth month , which underscores the extreme seriousness of maternal vitamin D deficiency and preeclampsia.
Vitamin D deficiency is associated with an increased risk of bacterial vaginosis [32, 36, 47]. One study reported a threefold increase in bacterial vaginosis in pregnant women who had a vitamin D level of less than 30 ng/mL . Bacterial vaginosis is clearly a threat to a pregnancy and to the life of the fetus, and is strongly associated with reproductive failure, fetal loss, premature rupture of membranes, and premature birth [48, 49]. Given the roles vitamin D plays in shaping the immune response to bacteria in the placenta, vitamin D sufficiency is one answer to this common reproductive threat .
Gestational diabetes is more common than reported and may occur in more than 14% of pregnancies in the United States; it can increase the need for cesarean section delivery . Vitamin D deficiency is positively associated with an increased risk of gestational diabetes  and risks of fetal abnormalities (e.g., macrosomia), birth trauma, neonatal respiratory distress syndrome, and other negative outcomes .
Levels of serum 25(OH)D below 20 ng/mL have been linked to a 2.7-fold increase in gestational diabetes . In patients with gestational diabetes, doses of 4,000 IU of vitamin D per day have been shown to decrease insulin resistance and fasting insulin levels, whereas a daily dose of 2,000 IU was ineffective . These data also suggest the need for vitamin D supplementation of 4,000 IU/day and maintaining serum 25(OH)D levels above 30 ng/mL.
Intrauterine growth restriction affects as many as 1 in 12 pregnancies, is associated with placental insufficiency, and can lead to fetal loss, perinatal asphyxia, and impaired cognition and cerebral palsy . Affected infants are predisposed to disease in their later life, including type 2 diabetes, hypertension, stroke, and coronary artery disease . In addition, maternal vitamin D deficiency has been associated with an increased risk of type 1 diabetes, multiple sclerosis, schizophrenia, autism, and asthma in offspring [32, 52].
In one study, the risk for small-for-gestational-age neonates was 2.4 times higher when the mother has a serum 25(OH)D level below 12 ng/ mL compared with mothers with levels of 20 ng/ mL [39, 55, 56]. According to one source, women who supplemented with vitamin D during pregnancy have a greater than 50% reduction in low-birthweight infants compared with women who did not supplement with vitamin D during pregnancy .
Pregnancy loss may terminate as many as 31% of all pregnancies . Studies involving in vitro fertilization have revealed the importance of vitamin D to the maintenance of pregnancy. Remarkably, one such study found the vitamin D levels in patients who achieved clinical pregnancy were substantially higher than were those who experienced pregnancy loss via spontaneous abortion, with those with a high vitamin D level achieving a fourfold greater pregnancy success rate than those with low vitamin D levels .
To underscore the value of adequate vitamin D supplementation in the prevention of premature birth, one study found a 50% reduction in preterm birth in pregnant women who received 4,000 IU vitamin D per day, as opposed to those who received lesser amounts (e.g., 400 or 2,000 IU) of daily supplementation [17,22,26].
Vitamin D deficiency is a major threat to maternal and fetal well-being, yet the epidemic of vitamin D deficiency continues. Clinicians are uniquely responsible for safe care and delivering appropriate instruction but overall are receiving a failing grade because of a lack of knowledge or attention to this matter. There are consequences, born out in the lives of mothers and their offspring, including the loss of life. Given the weight of the evidence, there is a pressing need for clinicians to recognize the dangers of maternal vitamin D deficiency and effectively identify and address this threat in the women under their care.
Levels of 25(OH)D should be measured before or during early pregnancy, with monitoring and retesting during pregnancy. Based on the findings, prescribing adequate oral supplementation of vitain D3 to maintain serum vitamin D concentration of more than 30 ng/mL (or preferably keep above 40 ng/mL) is recommended to mitigate risks. Awareness of such should be expanded to minimize the harm caused by what has been recognized as a global epidemic of maternal vitamin D deficiency.
Disclosure: The authors have no conflicts of interest. This work did not receive any grant from funding agencies in the public, commercial, or not-for-profit sectors.
Vitamin D Deficiency-Related Reproductive Consequences – April 2019
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- Heyden, E.L. and S.J. Wimalawansa, Vitamin D: Effects on Human Reproduction, Pregnancy, and Fetal Well-being. J Steroid Biochem Mol Biol, 2017.
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- Wimalawansa, S.J., D.M.S. Razzaque, and N.M. Al-Daghri, Calcium and Vitamin D in Human Health: Hype or Real? J Steroid Biochem Mol Biol, 2017. (online).
- Mir, S.A., et al., Efficacy and safety of Vitamin D supplementation during pregnancy: A randomized trial of two different levels of dosing on maternal and neonatal Vitamin D outcome. Indian J Endocrinol Metab, 2016. 20(3): p. 337-42.
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- Urrutia-Pereira, M. and D. Sole, Vitamin D deficiency in pregnancy and its impact on the fetus, the newborn and in childhood. Rev Paul Pediatr, 2015. 33(1): p. 104-13.
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- Holick, M.F., et al., Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab, 2011. 96(7): p. 1911-30.
- Grant, W.B., et al., Emphasizing the health benefits of vitamin D for those with neurodevelopmental disorders and intellectual disabilities. Nutrients, 2015. 7(3): p. 1538-64.
- Pludowski, P., et al., Vitamin D supplementation guidelines. J Steroid Biochem Mol Biol, 2018. 175: p. 125-135.
- Lerchbaum, E. and B. Obermayer-Pietsch, Vitamin D and fertility: a systematic review. Eur J Endocrinol, 2012. 166(5): p. 765-78.
- Blomberg Jensen, M., Vitamin D and male reproduction. Nat Rev Endocrinol, 2014. 10(3): p. 175-86.
- Anagnostis, P., S. Karras, and D.G. Goulis, Vitamin D in human reproduction: a narrative review. Int J Clin Pract, 2013. 67(3): p. 225-35.
- Sikgenc, M.M., et al., Bone disease in renal transplantation and pleotropic effects of vitamin D therapy. Transplant Proc, 2010. 42(7): p. 2518-26.
- Cashman, K.D., et al., Vitamin D deficiency in Europe: pandemic? Am J Clin Nutr, 2016. 103(4): p. 1033-44.
- Schulz, E.V., et al., Maternal vitamin D sufficiency and reduced placental gene expression in angiogenic biomarkers related to comorbidities of pregnancy. J Steroid Biochem Mol Biol, 2017. 173: p. 273-279.
- Grayson, R., Hawison, M, Vitamin D and human pregnancy. Fetal and Maternal Medicine Review, 2011. 22(1): p. 67-90.
- Dabrowski, F.A., B. Grzechocinska, and M. Wielgos, The role of vitamin D in reproductive health--a Trojan Horse or the Golden Fleece? Nutrients, 2015. 7(6): p. 4139-53.
- Baker, A.M., et al., A nested case-control study of midgestation vitamin D deficiency and risk of severe preeclampsia. J Clin Endocrinol Metab, 2010. 95(11): p. 5105-9.
- Baker, A.M., et al., First trimester maternal vitamin D status and risk for gestational diabetes mellitus: a nested case-control study. Diabetes Metab Res Rev, 2011.
- Shin, J.S., et al., Vitamin D effects on pregnancy and the placenta. Placenta, 2010. 31(12): p. 1027-34.
- Murthi, P., et al., Role of the Placental Vitamin D Receptor in Modulating Feto-Placental Growth in Fetal Growth Restriction and Preeclampsia-Affected Pregnancies. Front Physiol, 2016. 7: p. 43.
- Bakacak, M., et al., Comparison of Vitamin D levels in cases with preeclampsia, eclampsia and healthy pregnant women. Int J Clin Exp Med, 2015. 8(9): p. 16280-6.
- Gernand, A.D., et al., Maternal serum 25-hydroxyvitamin D and placental vascular pathology in a multicenter US cohort. The American Journal of Clinical Nutrition, 2013. 98(2): p. 383-388.
- Fanos, M., Vierucci, F., Saggese, G, Vitamin D in the perinatal period: an update. J. Ped. Neonatal Individualized Med, 2013. 2(2): p. 1-9.
- Liu, N.Q., et al., Vitamin D and the regulation of placental inflammation. J Immunol, 2011. 186(10): p. 5968-74.
- Senterre, J., Vitamin D metabolism in the perinatal period. Rev Med Liege, 1981. 36(24): p. 881-7.
- Shand, A.W., et al., Maternal vitamin D status in pregnancy and adverse pregnancy outcomes in a group at high risk for pre-eclampsia. BJOG, 2010. 117(13): p. 1593-8.
- Tabesh, M., et al., Maternal vitamin D status and risk of pre-eclampsia: a systematic review and meta-analysis. J Clin Endocrinol Metab, 2013. 98(8): p. 3165-73.
- Bodnar, L.M., et al., Maternal vitamin D deficiency increases the risk of preeclampsia. J Clin Endocrinol Metab, 2007. 92(9): p. 3517-22.
- Lain, K.Y. and J.M. Roberts, Contemporary concepts of the pathogenesis and management of preeclampsia. JAMA, 2002. 287(24): p. 3183-6.
- Christesen, H.T., et al., The impact of vitamin D on pregnancy: a systematic review. Acta Obstet Gynecol Scand, 2012. 91(12): p. 1357-67.
- Romero, R., et al., Bacterial vaginosis, the in flammatory response and the risk of preterm birth: a role for genetic epidemiology in the prevention of preterm birth. Am J Obstet Gynecol, 2004. 190(6): p. 1509-19.
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- Burris, H.H. and C.A. Camargo, Jr., Vitamin D and gestational diabetes mellitus. Curr Diab Rep, 2014. 14(1): p. 451.
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- Soheilykhah, S., et al., The effect of different doses of vitamin D supplementation on insulin resistance during pregnancy. Gynecol Endocrinol, 2013 29(4): p. 396-9.
- Regnault, T.R., et al., Placental development in normal and compromised pregnancies-- a review. Placenta, 2002. 23 Suppl A: p. S119-29.
- Gernand, A.D., et al., Maternal vitamin D status and small-for-gestational-age offspring in women at high risk for preeclampsia. Obstet Gynecol, 2014 123(1): p. 40-8.
- Leffelaar, E.R., T.G. Vrijkotte, and M. van Eijsden, Maternal early pregnancy vitamin D status in relation to fetal and neonatal growth: results of the multi-ethnic Amsterdam Born Children and their Development cohort. Br J Nutr, 2010. 104(1): p. 108-17.
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