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The earlier the better- preconception vitamin D - June 2018

The earlier the better: preconception vitamin D and protection against pregnancy loss.

Lancet Diabetes Endocrinol. 2018 Jun 5. pii: S2213-8587(18)30178-5. doi: 10.1016/S2213-8587(18)30178-5. [Epub ahead of print]
Hewison M, Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, Centre for Endocrinology, Diabetes and Metabolism, U. of Birmingham and Birmingham Health Partners, Birmingham, B15 2TT, UK m.hewison at bham.ac.uk.

PDF is available free at Sci-Hub
PMID: 29884467 DOI: 10.1016/S2213-8587(18)30178-5

This is an editorial comments on
Mumford SL, Garbose RA, Kim K, et al.
Association of preconception serum 25-hydroxyvitamin D concentrations with livebirth and pregnancy loss: a prospective cohort study. Lancet Diabetes Endocrinol 2018; online May 30. In VitaminDWiki Preconception vitamin D is great - every extra 10 ng associated with 10 percent more likely to have live birth – Aug 2018


Preconception supplementation appears to reduce problems with
Becoming pregnant
Miscarriage
First trimester supplementation reduces problems with
Infant teeth
Autism
Asthma
Healthy pregnancies need lots of vitamin D has the following summary

Problem
ReducesEvidence
0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRandomized Controlled Trial
3. Gestational Diabetes 3 times Randomized Controlled Trial
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times Randomized Controlled Trial
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times Randomized Controlled Trial
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
Randomized Controlled Trial
10. Childhood Wheezing 1.3 times Randomized Controlled Trial
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRandomized Controlled Trial
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times Randomized Controlled Trial
16. Childhood Respiratory Tract visits 2.5 times Randomized Controlled Trial


Fertility and Sperm category contains the following summary

91 items in Fertility or Sperm in VitaminDWiki

See also

Overview Women and Vitamin D
Overview Pregnancy and vitamin D    Fertility and Vitamin D – several articles
Endometriosis
Ensure a healthy pregnancy and baby - take Vitamin D before conception
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Conception and vitamin D snapshot as of 2012


Fertility

See also


Some related publications by M Hewison

Created by admin. Last Modification: Tuesday August 14, 2018 01:17:07 UTC by admin. (Version 11)
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