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In vitro fertilization not helped by vitamin D if ignore high levels and male levels – meta Mar 2016

Serum vitamin D status and in vitro fertilization outcomes: a systematic review and meta-analysis.

Arch Gynecol Obstet. 2016 Mar 29. [Epub ahead of print]
Lv SS1, Wang JY2, Wang XQ1, Wang Y1, Xu Y3.
1Department of Endocrinology, The People's Hospital of Deyang City, Deyang, 618000, Sichuan, China.
2Department of Endocrinology, Affiliated Hospital of Luzhou Medical College, Luzhou, 646000, Sichuan, China.
3Department of Endocrinology, Affiliated Hospital of Luzhou Medical College, Luzhou, 646000, Sichuan, China. Lss219219 at sina.cn.

VitaminDWiki Summary

VitaminDWiki bought the PDF (~$40) to find out how they disagreed with all previous studies

  1. The study decided ahead of time that 20 nanograms should be enough
    (China believes that 20 ng is enough for anything, but really need a minimum of 30 ng)
  2. The study ignored male vitamin D levels – which are similarly important
  3. 4 of the 5 studies chosen showed a significant benefit with higher vitamin D
    But: 1 study did not show a benefit
    it had 10 times fewer controls than the other studies (and is behind a paywall)

See also VitaminDWiki

Appears that conventional IVF has only 20% success rate for age 40+

  • NYT Oct 2016
    No idea of Vitamin D benefit to IVF vs age

To assess the correlation between serum 25-hydroxy vitamin D 25(OH)D status and outcomes of in vitro fertilization (IVF) in infertile women through review systematically.
We used Embase, Pubmed, and Cochrane database to identify all studies that assessed the correlation between serum vitamin D levels and IVF outcomes in infertile women up until 30 June 2015, with the restricted language of English. We included studies that compared IVF outcomes between infertile women vitamin D <20 ng/ml and vitamin D ≥20 ng/ml. The results were summarized using Stata 12.0 software. For studies reported dichotomous outcomes (clinical pregnancy rate and live birth rate), we pooled the relative risks ratios (RRs) and 95 % confidence intervals (CIs) in a random effects model.
Our search resulted in the retrieval and screening of 134 studies. Of those, five studies were included in our meta-analysis. The risk for lower clinical pregnancy rate was not significantly increased in the deficient group (RR 0.88, 95 % CI 0.69-1.11). Lower vitamin D status was associated with lower live birth rate (RR 0.76, 95 % CI 0.61-0.93).
There is no significant correlation between deficient serum vitamin D level and lower clinical pregnancy rate in infertile woman undergoing in vitro fertilization. On the other hand, deficient vitamin D level was related to lower live birth rate.

PMID: 27022933 Publisher wants $40 for the PDF

DOI: 10.1007/s00404-016-4058-1