Exposure to vitamin D fortified margarine in women with fertility problems and chance of live birth: results from a Danish population-based cohort study
Fertility and Sterility Nov 21, 2019
Allan Jensen, M.Sc., Ph.D., Michella L. Nielsen, M.D., Sonia Guleria, M.D., Susanne K. Kjaer, M.D., D.M.Sc., Berit L. Heitmann, Ph.D., D.M.Sc., Ulrik S. Kesmodel, M.D., Ph.D.
- Birth rates doubled with male Vitamin D intervention – RCT Nov 2017
- Assisted Reproduction – 5 studies concluded vitamin D repletion helps – Review March 2015
- IVF 4X more successful for white women with lots of vitamin D – Oct 2012
- Assisted Reproduction might be aided by Vitamin D – review Dec 2014
- In-vitro Fertilization costs at least 10,000 dollars, Vitamin D costs 5 dollars
- Conception within 6 months 3X more likely if high vitamin D – Oct 2019
- Pregnancy success increased 30 percent if sunny (or vitamin D) one month earlier – June 2015
- Preconception vitamin D is great - every extra 10 ng associated with 10 percent more likely to have live birth – Aug 2018
- Women with more than minimum vitamin D were 3.4 X more likely to achieve pregnancy and 1.6 X more likely to have live births – June 2017
- Vitamin D is needed for human fertility – goal is 50 ng – Sept 2018
Increased male Vitamin D also increases fertility
- Vitamin D somewhat assists reproduction – both the mother and the father – May 2014
- Male fertility 4 X higher if high Vitamin D – Nov 2015
Fortificatiion change in Denmark
- 60 percent more life births after infertility diagnosis if Vitamin D fortification (Denmark) - Nov 2019
- Vitamin D food fortification during pregnancy reduced gestational diabetes in daughters by 13 percent – Nov 2018
- Vitamin D added to margarine reduced inflammatory bowel disease by 13 percent 30 years later – Nov 2019
- Preeclampsia of offspring cut in half if mother who smoked had vitamin D fortified margarine – Dec 2017
- Danish study of childhood diseases vs vitamin D fortification – May 2013
- 9 studies by Denmak D-Tech group (fortifiy Margarine with Vitamin D) online as of Nov 2019
To study the association between extra vitamin D from a mandatory margarine fortification program and chance of live birth among infertile women.
Design: Nationwide cohort study.
Setting: Not applicable.
Patient(s): The study population consisted of 16,212 women diagnosed with infertility from June 1, 1980, to August 31, 1991.
We took advantage of the mandatory vitamin D fortification program of margarine in Denmark that was abruptly stopped on May 31, 1985. The termination of the vitamin D fortification served as a cutoff point to separate the study population into various exposure groups.
Main Outcome Measure(s)
Odds ratios and 95% confidence intervals for the association between vitamin D exposure status and chance of a live birth within 12, 15, and 18 months after first infertility diagnosis.
Women who were diagnosed with infertility during the vitamin D–exposed period had an increased chance of a live birth compared with women diagnosed with infertility during the nonexposed period. For women diagnosed with infertility during the wash-out period, the chance of a live birth was also increased, but somewhat lower. Similar estimates were obtained with longer follow-up, in women with anovulatory infertility, and little seasonal variation was observed when calendar period of conception was applied.
Our findings suggest that infertile women exposed to extra vitamin D from a margarine fortification program had an increased chance of live birth compared with women not exposed to extra vitamin D from fortification.