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Poor fertility in both women and men associated with low vitamin D – review Feb 2018

Vitamin D, PCOS and androgens in men: a systematic review.

Endocr Connect. 2018 Feb 15. pii: EC-18-0009. doi: 10.1530/EC-18-0009. [Epub ahead of print]
Trummer C1, Pilz S2, Schwetz V3, Obermayer-Pietsch BR4, Lerchbaum E5.

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BACKGROUND: Accumulating evidence from animal and human studies suggests that vitamin D is involved in many functions of the reproductive system in both genders.

AIM: The aim of this review was to provide an overview on the effects of vitamin D on polycystic ovary syndrome (PCOS) in women and androgen metabolism in men.

We performed a systematic literature search in Pubmed for relevant English language publications published from January 2012 until July 2017.

The vitamin D receptor and vitamin D metabolizing enzymes are found in reproductive tissues of women and men. In women, vitamin D status has been associated with several features of PCOS. In detail, cross-sectional data suggest a regulatory role of vitamin D in PCOS-related aspects such as ovulatory dysfunction, insulin resistance as well as hyperandrogenism. Moreover, results from randomized controlled trials (RCTs) suggest that vitamin D supplementation may be beneficial for metabolic, endocrine and fertility aspects in PCOS. In men, vitamin D status has been associated with androgen levels and hypogonadism. Further, there is some evidence for a favourable effect of vitamin D supplementation on testosterone concentrations, although others failed to show a significant effect on testosterone levels.

In summary, vitamin D deficiency is associated with adverse fertility outcomes including PCOS and hypogonadism, but the evidence is insufficient to establish causality. High quality RCTs are needed to further evaluate the effects of vitamin D supplementation in PCOS women as well as on androgen levels in men.

PMID: 29449314 DOI: 10.1530/EC-18-0009

Created by admin. Last Modification: Saturday February 17, 2018 13:53:46 GMT-0000 by admin. (Version 2)

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