Vitamin D improves Infertility in 9 ways (50 references, PDF behind paywall) – May 2023

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Vitamin D and infertility

Curr Opin Obstet Gynecol . 2023 May 22. doi: 10.1097/GCO.0000000000000887
Samantha Simpson 1, Lubna Pal 2

Purpose of review: Vitamin D deficiency has been implicated as a contributing factor to a spectrum of reproductive health burden, including

• difficulty conceiving,
• pathogenesis of gynaecological disorders such as
  • uterine fibroids and endometriosis, to
• metabolic and endocrine burden of polycystic ovarian syndrome (PCOS).

Recent findings: There have been recent publications showing that in infertile women who are supplemented with vitamin D,

• there are higher pregnancy rates;
• there are improved ovarian reserve parameters in women with diminished ovarian reserve;
• curtailed fibroid growth in those with uterine myomas;
• lessened dysmenorrhea in endometriosis patients; and
• improved menstrual regularity,
• lowered testosterone, AMH and insulin levels in women with PCOS.

In infertile men, sperm parameters, especially motility, are positively correlated with vitamin D serum levels.

Summary: Vitamin D status appears to be relevant to reproductive physiology, and to physiological processes underlying common gynaecological disorders as well as for reproductive success.

References

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VitaminDwiki – Fertility and Sperm category contains

136 items in Fertility or Sperm in VitaminDWiki

See also:
Overview Women and Vitamin D
Overview Pregnancy and vitamin D    Fertility and Vitamin D – several articles
Endometriosis
Ensure a healthy pregnancy and baby - take Vitamin D before conception
IVF OR "IN VITRO FERTILIZATION" etc. in 18 VitaminDWiki titles
- - - - - - - - -

• Vitamin D is needed for human fertility – goal is 50 ng – Sept 2018
• In-vitro Fertilization costs at least 10,000 dollars, Vitamin D costs 5 dollars
• Infertile patients 1.7X more-likely to become pregnant if take Vitamin D – meta-analysis Feb 2023
• Live birth 1.7 X more likely after IVF if good level of vitamin D – meta-analysis Aug 2020
• If diagnosed infertile, more likely to have live birth if Vitamin D fortification – Feb 2020
• Preconception vitamin D is great - every extra 10 ng associated with 10 percent more likely to have live birth – Aug 2018
• Women with more than minimum vitamin D were 3.4 X more likely to achieve pregnancy and 1.6 X more likely to have live births – June 2017
• Assisted Reproduction – 5 studies concluded vitamin D repletion helps – Review March 2015
• Pregnancy success increased 30 percent if sunny (or vitamin D) one month earlier – June 2015
• IVF 4X more successful for white women with lots of vitamin D – many studies

Increased male Vitamin D increases fertility

• Birth rates doubled with Vitamin D - 300,000 for infertile men – RCT Nov 2017
• Higher vitamin D results in 22% fewer abnormal sperm (Mendelian analysis) – May 2024
• Conception was 3.7X more likely if the male had a good level of Vitamin D – July 2022
• Far better sperm in fertility clinic if more than 30 ng of Vitamin D - June 2022
• Fertility (sperm) associated with vitamin D – meta-analysis Sept 2019
• Infertility - 71 percent of the time of BOTH partners had less than 20 ng of Vitamin D – Aug 2017
• Male fertility 4 X higher if high Vitamin D – Nov 2015
• Vitamin D somewhat assists reproduction – both the mother and the father – May 2014

Decreased Fertility if decreased Vitamin D Receptor

• Unexplained infertility 4X more likely if poor vitamin D receptor – Dec 2020
• Male Infertility is associated with poor Vitamin D Receptor – July 2021