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Testosterone 14% higher in those with high vitamin D – Aug 2016

Association between serum 25-hydroxyvitamin D and serum sex steroid hormones among men in NHANES.

Clin Endocrinol (Oxf). 2016 Aug;85(2):258-66. doi: 10.1111/cen.13062. Epub 2016 Apr 6.
Anic GM1,2, Albanes D2, Rohrmann S3, Kanarek N4,5, Nelson WG4,5,6, Bradwin G7, Rifai N7, McGlynn KA2, Platz EA4,6,8, Mondul AM9.

Recent literature suggests that high circulating vitamin D may increase prostate cancer risk. Although the mechanism through which vitamin D may increase risk is unknown, vitamin D concentration could influence circulating sex steroid hormones that may be associated with prostate cancer; an alternate explanation is that it could be associated with prostate-specific antigen (PSA) concentration causing detection bias.

We examined whether serum vitamin D concentration was associated with sex steroid hormone and PSA concentrations in a cross-sectional analysis of men in the National Health and Nutrition Examination Surveys (NHANES).

Testosterone, oestradiol, sex hormone-binding globulin (SHBG), androstanediol glucuronide, and 25-hydroxyvitamin D (25(OH)D) were measured in serum from men aged 20 and older participating in NHANES III (n = 1315) and NHANES 2001-2004 (n = 318). Hormone concentrations were compared across 25(OH)D quintiles, adjusting for age, race/ethnicity, body fat percentage, and smoking. PSA concentration was estimated by 25(OH)D quintile in 4013 men from NHANES 2001-2006.

In NHANES III, higher testosterone (quintile

  • (Q) 1 = 17·2, 95% confidence interval (CI) = 16·1-18·6;
  • Q5 = 19·6, 95% CI = 18·7-20·6 nmol/l, P-trend = 0·0002)

and SHBG (Q1 = 33·8, 95% CI = 30·8-37·0; Q5 = 38·4, 95% CI = 35·8-41·2 nmol/l, P-trend = 0·0005) were observed with increasing 25(OH)D. Similar results were observed in NHANES 2001-2004. PSA concentration was not associated with serum 25(OH)D (P-trend = 0·34).

Results from these nationally representative studies support a positive association between serum 25(OH)D and testosterone and SHBG. The findings support an indirect mechanism through which vitamin D may increase prostate cancer risk, and suggest the link to prostate cancer is not due to PSA-detection bias.

PMID: 26991691 PMCID: PMC4946966 [-Available on 2017-08-01] DOI: 10.1111/cen.13062

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