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Vitamin D - Effects on Human Reproduction, Pregnancy, and Fetal Well-being – Dec 2017

The Journal of Steroid Biochemistry and Molecular Biology, online 17 Dec 2017, https://doi.org/10.1016/j.jsbmb.2017.12.011


Pregnancy category starts with

891 items in Pregnancy category

 - see also

Healthy pregnancies need lots of vitamin D has the following summary

Vit. D
0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT
3. Gestational Diabetes 3 times RCT
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times RCT
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times RCT
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
10. Childhood Wheezing 1.3 times RCT
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRCT
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times RCT
16. Childhood Respiratory Tract visits 2.5 times RCT

RCT = Randomized Controlled Trial
Others by Heyden include

Others by Wimalawansa include

 Download the PDF from Researchgate via VitaminDWiki

E.L. Heyden a, , S.J. Wimalawansa b, ,

  • Vitamin D deficiency may exceed 40% among pregnant women, subjecting both mother and fetus to adverse consequences and outcomes.
  • Maternal vitamin D deficiency increases the risk of preeclampsia, bacterial vaginosis, gestational diabetes, spontaneous abortions, and preterm labor and can harm the fetus by growth restriction, physical deformity, and increasing future health risks.
  • In humans, insufficient UVB exposure is the primary cause of vitamin D deficiency; lifestyle choices are the predominant cause of insufficient exposure to sunlight.
  • Diet typically supplies less than 10% of the human need of vitamin D, necessitating safe UVB exposure or supplementation.
  • Emerging data and evolving consensus place the need for vitamin D supplementation at 4,000 IU per day during pregnancy for optimal healthy pregnancy and its related outcomes.

Offspring Benefits
Maternal Benefits
Pregnancy places exceptional demands on vitamin D and calcium availability; thus, their deficiencies during pregnancy threaten the woman and her fetus. Globally, vitamin D and other micronutrient deficiencies are common during pregnancy, especially in developing countries where pregnant women have less access to supplements. Vitamin D deficiency has been reported to be as high as 40% among pregnant women. As a pregnancy progresses, the requirements for vitamin D increase and can worsen preexisting hypovitaminosis D.

Consequently, hypovitaminosis D is associated with a higher incidence of

  • fetal miscarriage,
  • preeclampsia,
  • gestational diabetes,
  • bacterial vaginosis, and
  • impaired fetal and childhood growth and development.

This review explores the recent advances in the understanding of vitamin D and the pivotal role it plays in human reproduction, with an emphasis on pregnancy. Given the seriousness of the issue, there is a pressing need for clinicians to become aware of the risks associated with not identifying and correcting vitamin D deficiency. Identifying and correcting vitamin D deficiency, including safe exposure to sunlight, is particularly relevant for those who seek assistance with fertility issues or prenatal counseling and those in the beginning of their pregnancy. The data point to a significant protective effects of vitamin D during pregnancy when the 25(OH)D serum level exceeds 30 ng/mL before pregnancy and during the first trimester and, sufficient levels are maintained throughout the pregnancy.

Created by admin. Last Modification: Friday October 12, 2018 17:16:57 GMT-0000 by admin. (Version 17)

Attached files

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10530 Maternal Benefits.jpg admin 12 Sep, 2018 73.25 Kb 1003
10529 Offspring benefits.jpg admin 12 Sep, 2018 99.63 Kb 1015
10528 VitDReproduction-SBMB-HeydenWimalawansa-2018s.pdf admin 12 Sep, 2018 458.66 Kb 646
9060 Vit D pregnancy Sunil.jpg admin 29 Dec, 2017 51.34 Kb 4855