Reproductive Biology and Endocrinology 2014,12:47 doi:10.1186/1477-7827-12-47
Valeria S Vanni (email@example.com) Paola Vigano (firstname.lastname@example.org) Edgardo Somigliana (email@example.com) Enrico Papaleo (firstname.lastname@example.org) Alessio Paffoni (email@example.com) Luca Pagliardini (firstname.lastname@example.org) Massimo Candiani (email@example.com)
Article type Review; Submission date 14 January 2014; Acceptance date 10 May 2014; Publication date 31 May 2014
Article URL http://www.rbej.com/content/12/1/47
Accumulating evidence from animal and human studies suggests that vitamin D is involved in many functions of the human reproductive system in both genders, but no comprehensive analysis of the potential relationship between vitamin D status and Assisted Reproduction Technologies (ART) outcomes is currently available. On this basis, the purpose of this systematic review and meta-analysis was to perform an in-depth evaluation of clinical studies assessing whether vitamin D status of patients undergoing ART could be related to cycle outcome variables. This issue is of interest considering that vitamin D deficiency is easily amenable to correction and oral vitamin D supplementation is cheap and without significant side effects. Surprisingly, no studies are currently available assessing vitamin D status among male partners of couples undergoing ART, while seven studies on vitamin D status of women undergoing controlled ovarian hyperstimulation (COH) for ART were found and included in the review. Results show that vitamin D deficiency is highly prevalent among women undergoing COH, ranging from 21% to 31% across studies conducted in Western countries and reaching 75-99% in Iranian studies. Data on vitamin D deficiency (25-hydroxyvitamin D serum levels <20 ng/ml) in relation to ART outcomes could be extracted from three studies and included in the meta-analysis, yielding a common risk ratio (RR) of 0.89 (95% CI 0.531.49) and showing a lower but not statistically significant likelihood of clinical pregnancy for vitamin-D-deficient women compared with vitamin-D-sufficient patients.
In conclusion, there is insufficient evidence to support the routine assessment of vitamin D status to predict the clinical pregnancy rate in couples undergoing ART. The partly conflicting results of the available studies, potentially explaining the lack of statistical significance for a negative influence of vitamin D deficiency on clinical pregnancy rate, are likely secondary to confounders and insufficient sample size, and further larger cohort and randomised controlled studies are required.
PDF is attached at the bottom of this page
Most likely would have found much more benefit if they had considered levels >, < 40 ng instead of 20 ng
- Male infertility associated with low vitamin D levels – Dec 2012
- IVF 4X more successful for white women with lots of vitamin D – Oct 2012
- Reproduction function in males improved by vitamin D – review Aug 2012
- All items in category Fertility and Sperm - Vitamin D
117 itemsVitamin D somewhat assists reproduction – both the mother and the father – May 2014 3347 visitors, last modified 10 Jun, 2014,This page is in the following categories (# of items in each category)