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Reproduction function in males improved by vitamin D – review Aug 2012

Vitamin D metabolism, sex hormones, and male reproductive function

Reproduction August 1, 2012 144 135-152
Martin Blomberg Jensen blombergjensen at gmail.com
University Department of Growth and Reproduction,
Rigshospitalet, Section 5064, Blegdamsvej 9, 2100 Copenhagen, Denmark

The spectrum of vitamin D (VD)-mediated effects has expanded in recent years, and VD is now recognized as a versatile signaling molecule rather than being solely a regulator of bone health and calcium homeostasis. One of the recently identified target areas of VD is male reproductive function. The VD receptor (VDR) and the VD metabolizing enzyme expression studies documented the presence of this system in the testes, mature spermatozoa, and ejaculatory tract, suggesting that both systemic and local VD metabolism may influence male reproductive function. However, it is still debated which cell is the main VD target in the testis and to what extent VD is important for sex hormone production and function of spermatozoa.

This review summarizes descriptive studies on testicular VD metabolism and spatial distribution of VDR and the VD metabolizing enzymes in the mammalian testes and discusses mechanistic and association studies conducted in animals and humans. The reviewed evidence suggests some effects of VD on estrogen and testosterone biosynthesis and implicates involvement of both systemic and local VD metabolism in the regulation of male fertility potential.

Received 27 February 2012, 2012 Society for Reproduction and Fertility

PDF is attached at the bottom of this page
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A portion of Table: 2 Rats from 1992 data

Variablelots of Dlittle D
Positive sperm smear/day0.200.11
Females giving birth to normal litters3220
Pregnancies per day0.150.04
Mean litter size 12.610.4

See also VitaminDWiki

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1482 Vitamin D in male reproduction - 2012.pdf PDF admin 24 Jul, 2012 21:36 533.16 Kb 751
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