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Vitamin K can reduce aging - April 2021


The Role of Vitamin K in Humans: Implication in Aging and Age-Associated Diseases

Antioxidants 2021, 10(4), 566; https://doi.org/10.3390/antiox10040566
by Daniela-Saveta Popa 1,*ORCID,Galya Bigman 2ORCID and Marius Emil Rusu 3ORCID

As human life expectancy is rising, the incidence of age-associated diseases will also increase. Scientific evidence has revealed that healthy diets, including good fats, vitamins, minerals, or polyphenolics, could have antioxidant and anti-inflammatory activities, with antiaging effects. Recent studies demonstrated that vitamin K is a vital cofactor in activating several proteins, which act against age-related syndromes. Thus, vitamin K can carboxylate osteocalcin (a protein capable of transporting and fixing calcium in bone), activate matrix Gla protein (an inhibitor of vascular calcification and cardiovascular events) and carboxylate Gas6 protein (involved in brain physiology and a cognitive decline and neurodegenerative disease inhibitor). By improving insulin sensitivity, vitamin K lowers diabetes risk. It also exerts antiproliferative, proapoptotic, autophagic effects and has been associated with a reduced risk of cancer. Recent research shows that protein S, another vitamin K-dependent protein, can prevent the cytokine storm observed in COVID-19 cases. The reduced activation of protein S due to the pneumonia-induced vitamin K depletion was correlated with higher thrombogenicity and possibly fatal outcomes in COVID-19 patients. Our review aimed to present the latest scientific evidence about vitamin K and its role in preventing age-associated diseases and/or improving the effectiveness of medical treatments in mature adults ˃50 years old.
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148+ VitaminDWiki pages have AGING in the title

This list is automatically updated

Items found: 161
Title Modified
Death within 1 year if over age 80: low vitamin D was almost the strongest reason – Aug 2024 08 Aug, 2024
New anxiety after age 50 predicts 2.1 X increased risk of Parkinson’s – July 2024 06 Jul, 2024
Life extension by physical activity or more than 34 ng of Vitamin D – together they reduce aging by 1.3 years – July 2024 13 Jun, 2024
Blood-brain barrier decreases with age, how to restore it 19 May, 2024
Blood-brain barrier decreases with age, how to restore it 19 May, 2024
US has the most vaccinations before age 1 and the most deaths - March 2024 26 Mar, 2024
Vitamins etc, appear to slow down epigenetic aging and reduce inflammation – March 2024 26 Mar, 2024
Vitamin D deficiency predicted with 91% accuracy ( AI, age, paywall) - April 2024 22 Mar, 2024
Vitamin D and Aging: Central Role of Immunocompetence – Carlberg Jan 2024 21 Mar, 2024
The Science of Magnesium and Its Role in Aging and Disease - Patrick March 2024 20 Mar, 2024
Predictors of low vitamin D: race, age, and BMI (confirmed now by Machine Learning) – Feb 2024 07 Mar, 2024
Reduce ageing with Vitamin D, Omega-3, and Exercise (video) - Patrick March 2024 06 Mar, 2024
CDC recommends 100 vaccinations by age 18 – Feb 2024 15 Feb, 2024
Stroke 3 times more likely if dark skin woman has Hypertension before age 35 - Feb 2024 03 Feb, 2024
Vitamin K can reduce aging - April 2021 25 Dec, 2023
Asthma by age 7 if wheezing before preschools and poor vitamin D Receptor - May 2023 21 Dec, 2023
How Not To Age book (diet, exercise, supplements) Dr. Greger - Dec 2023 10 Dec, 2023
79% increase in cancer under age 50 in 3 decades - Sept 2023 24 Nov, 2023
50% increase in Cancer deaths (age 15-44) since before COVID - Nov 2023 21 Nov, 2023
Fatigue reduced by Vitamin D (Cancer, muscle, MS, age, etc) - many studies 12 Nov, 2023
Vitamin D Receptors in muscles decrease with age in those with Osteoporosis - 2018 20 Aug, 2023
1 % weight loss delays brain aging by nearly nine months - RCT April 2023 28 Jul, 2023
Age-Related Macular Degeneration and Vitamin D - many studies 27 Jun, 2023
Infants getting an additional 800 IU of vitamin D for 2 years had 60% fewer psychiatric symptoms at age 7 – RCT May 2023 19 May, 2023
Better neurodevelpment at age 2 if high Vitamin D during all phases of pregnancy – March 2023 27 Mar, 2023
Shingles risk increase 15% with COVID and if COVID vaccine in those under age 50 – Jan 2023 04 Jan, 2023
Vitamin D reduces aging and prevents disease (less oxidative stress) - Dec 2022 07 Dec, 2022
Male brains age faster if low vitamin D (perhaps male-pattern baldness fights this) - Oct 2022 31 Oct, 2022
1,000 X lower COVID mortality rate in 2020 for age 10 vs 65 – Oct 2022 18 Oct, 2022
Aging of the Immune system (Immunosenescence): micronutrients and gut microbiota – Oct 2022 03 Oct, 2022
Number needed to vaccinate to prevent 1 Omicron death: 30,000 for age 60-70 - Sept 2022 29 Sep, 2022
Age-related loss of strength (Dynapenia) 1.7X more likely if low Vitamin D – Sept 2022 16 Sep, 2022
Vaccinations banned in UK if under age 12, US planning on annual vaccinations - Sept 2022 07 Sep, 2022
Vaccine holdouts aren't Republicans, but those under age 60 where perceived risk is worse than COVID – Dec 2021 21 Aug, 2022
28,859 deaths and 238,412 serious injuries due to vaccines, how many more when add ages 0.5 - 5 – June 2022 21 Jun, 2022
Vitamin D supplementation is associated with slower epigenetic aging - May 2022 21 Jun, 2022
Ageing faster and more knee pain are associated with low vitamin D – March 2022 08 Mar, 2022
Skin Aging and Vitamin D - many studies 08 Feb, 2022
Immune system degrades with age (perhaps Vitamin D can help) - Jan 2022 30 Jan, 2022
Increase in non-COVID deaths (ages 18-64) in Indiana, India, etc. - Jan 5, 2022 06 Jan, 2022
COVID Hospitalization vs age and variant - Dec 10, 2021 11 Dec, 2021
Vaccinated have HIGHER infection rates than unvaxxed (UK age 30-70) - Dec 9, 2021 10 Dec, 2021
LLLT reverses Age-related Macular Degeneration for a while - multiple studies 28 Nov, 2021
Severe fatigue and headache in 4 pct of vaccinated, age 16-25 - Oct 2021 27 Oct, 2021
Fecal transplant from young reduced age-associated defects in old (mice so far) – Aug 2021 27 Aug, 2021
Many Vitamin D metabolites: some help skin aging, reduce Cytokine storms, but are not tested – Aug 2021 27 Aug, 2021
Age of menopause increases if add vitamin D or UVB 25 Aug, 2021
Several advanced-maternal-age problems reduced if given Vitamin D during pregnancy (mice in this case) – July 2021 11 Aug, 2021
Parathyroid Hormone levels increase 63 percent with age (33,000 people) – Sept 2017 17 May, 2021
Parathyroid hormone level is inversely associated with both Vitamin D and age – April 2021 17 May, 2021
Poorer sleep as Vitamin D levels drop with age – March 2021 20 Feb, 2021
Low muscle mass at least 2X more likely if low Vitamin D (Korea, all ages) – Dec 2020 04 Jan, 2021
Increasing Vitamin D in aged care facilities to more than 800 IUs did not reduce falls – Oct 2020 07 Oct, 2020
Parathyroid increase with age associated with worsening Vitamin D genes – April 2020 01 May, 2020
My balance significantly improved at age 73 (perhaps Vitamin D, B12, or Omega-3) – Jan 2020 24 Jan, 2020
Boys who were born Small for Gestational age are 1.9X more likely to be infertile – Dec 2019 20 Dec, 2019
Preemies still have low vitamin D at age 6 – Oct 2019 30 Oct, 2019
Preterm birth increases risk of heart disease by 1.5 X by age 40 – June 2019 06 Aug, 2019
Ability to walk at age 1 is 3.9 X more likely if sufficient vitamin D – July 2019 23 Jul, 2019
Off topic: Skin aging reversed with by oral collagen – trials and reviews 03 Jul, 2019
Vitamin D for skin anti-aging – liposomal base is probably 1.6X better than oil base (in rats) – July 2019 03 Jul, 2019
Low back pain over age 30 – about 1 in 10 – Review Oct 2015 30 Jun, 2019
Double digit increases in many health problems for those aged 21-36 in just 4 years - April 2019 08 Jun, 2019
Deaths due to falls doubled in just a decade (age-adjusted, perhaps decreased vitamin D) – June 2019 04 Jun, 2019
Low Vitamin D is one of the causes of oxidative stress and aging – March 2019 15 May, 2019
Medicaid pays for 70 percent of US pregnancies for women under age 25 – April 2019 25 Apr, 2019
Aging leads to a decrease of vitamin D getting to cells – Sept 2017 26 Mar, 2019
Response to UV varies more with pigment genes and age than skin color – Jan 2019 24 Mar, 2019
Response to UV varies more with pigment genes and age than skin color – Feb 2019 24 Mar, 2019
Age-Related Macular Degeneration - Diet, bionome, Vitamin D, CBD, Avastin, etc 19 Mar, 2019
Vitamin D and Age-Related Macular Degeneration (and 2 AMD meta-analyses) – Oct 2017 15 Mar, 2019
All preteen aged girls in India taking 2,000 IU of vitamin D got levels above 20 ng – RCT Nov 2018 08 Mar, 2019
Vitamin D and Ageing (29 page chapter, VDR decreases with age) – Feb 2019 23 Feb, 2019
Far healthier and stronger at age 72 due to supplements 27 Jan, 2019
Vitamin D receptors get worse with age with osteoporosis – Dec 2018 30 Dec, 2018
Off Topic: Premature birth results in less schooling and income (age 28, 228,000 Danes) – Dec 2018 15 Dec, 2018
Healthy aging associated with higher levels of both Vitamin D and Omega-3 – Dec 2018 12 Dec, 2018
Vitamin D consensus for Italian children, 30 ng needed, up to 4,000 IU if over age 10 – May 2018 16 Nov, 2018
Attention-Deficit-Hyperactivity Disorder increasing (2.7X in US Blacks under age 18 in 20 years) – Sept 2018 11 Sep, 2018
Small for gestational age birth was 6.5X more likely if mother was vitamin D deficient – March 2015 27 Jun, 2018
Half as many Small for Gestational Age infants when take 600 IU of vitamin D while pregnant – June 2018 27 Jun, 2018
Less than half of health providers recommend 600 to 1000 IU of vitamin D (age 1-18) – May 2018 25 May, 2018
Suicides are now the 2nd largest cause of death for age 10-35 (perhaps low Vitamin D) – May 2018 16 May, 2018
Vitamin D reduced so low that Victorian age diseases are returning 05 Apr, 2018
Vitamin D gene expression varies with Epileptic age – March 2018 20 Mar, 2018
Prematurely aging kids (Hutchinson-Gilford Progeria Syndrome) might be helped by Vitamin D– March 2018 20 Mar, 2018
Hypothesis – neuromuscular aging can be reduced by nutrient supplementation (Vitamin D, Omega-3, etc) – Feb 2018 22 Feb, 2018
Vitamin D 1000 IU or more: 1 in 3 of those over age 60 as of 2013– JAMA June 2017 20 Feb, 2018
Vitamin D levels in juveniles in UAE decrease with age – Jan 2017 12 Dec, 2017
Hypothesis – less vitamin D results in faster aging – Nov 2017 17 Nov, 2017
The Convergence of Two Epidemics: Vitamin D Deficiency in Obese School-aged Children – Jan 2018 21 Oct, 2017
Small for gestational age is 1.6 X more likely if mother was vitamin D deficient – meta-analysis Aug 2017 28 Aug, 2017
Less vitamin D gets to cells as you age - fewer Vitamin D Receptors - 2004 25 Aug, 2017
Aging leads to a decrease in vitamin D receptor number in several organs (behind paywall) – Sept 2017 25 Jul, 2017
Multiple Sclerosis risk of relapse reduced by 13 percent for every 2.5 ng higher level of vitamin D (under age 37) – June 2017 18 Jul, 2017
Many diseases of aging are associated with low vitamin D – Dec 2014 14 Apr, 2017
Symptoms of vitamin D deficiency vary with the age of the child – Feb 2013 09 Apr, 2017
Genes which regulate active vitamin D worsen with age – Oct 2016 31 Oct, 2016
Less able to understand language at age 2 if low vitamin D during second trimester – Dec 2015 16 Sep, 2016
‘Cracking the Aging Code' with vitamin D, Metformin, etc. Book June 2016 14 Jul, 2016
Grassroots Health participants Vitamin D vs age, intake, and resulting level – Sept 2013 29 Jun, 2016
Prenatal soft drink resulted in 2 times more overweight babies at age 12 months (vitamin D not mentioned) – May 2016 11 May, 2016
Infants getting 1600 IU vitamin D during first year were more active and leaner at age 3 – RCT Feb 2016 06 May, 2016
Prenatal Vitamin D (35,000 weekly) resulted in 1 cm taller infants at age 1 year – RCT Aug 2013 30 Apr, 2016
Prenatal Vitamin D (35,000 weekly, 3rd trimester) resulted in 1 cm taller infants at age 1 year – RCT Aug 2013 30 Apr, 2016
Small for gestational age and insulin at age 6 – Sept 2012 21 Apr, 2016
Small for gestational age with low vitamin D – 3.6X higher for blacks than whites – April 2016 21 Apr, 2016
Anti-aging Effect of Magnesium on Telomeres (in rats) - Mar 2014 15 Apr, 2016
Intestines do not process active vitamin D as well as you age – June 2012 09 Apr, 2016
Intestines do not process vitamin D as well as you age – June 2012 09 Apr, 2016
Male late stage Age-Related Macular Degeneration is strongly associated with low vitamin D – July 2014 04 Apr, 2016
Coronary Heart Disease 3 times more likely if endometriosis before age 40 (vitamin D not mentioned) – March 2016 31 Mar, 2016
PTH does not plateau with increasing vitamin D, but does decrease with patient age – Aug 2012 29 Mar, 2016
Hypothesis: Age-related diseases due to lack of nutrients like vitamin K – Ames Triage Theory 18 Mar, 2016
Causes of death vs age - Jan 2016 05 Jan, 2016
Asthma at age 20 increased if vitamin D during pregnancy was higher than 50 ng – Oct 2015 04 Nov, 2015
Leading cause of death age 0-5 – vitamin D deficiency 08 Sep, 2015
Vitamin D and Omega-3 may reduce cortical atrophy with age – Nov 2013 14 Jul, 2015
79 percent of middle aged Americans had less than 32 ng of vitamin D – July 2010 31 May, 2015
Obese of all ages have lower levels of vitamin D – meta-analysis May 2015 10 May, 2015
Age-related cognitive decline in rats mitigated by Vitamin D intervention – RCT Oct 2012 01 May, 2015
Diabetes decreased in aged mice supplemented with vitamin D – April 2015 15 Apr, 2015
How many minutes of sun do I need – age, skin color, UV index – Nov 2014 26 Nov, 2014
Smoking associated with 9 ng less vitamin D age 40-50 – Nov 2014 24 Nov, 2014
More aged are falling - even age-adjusted - Nov 2014 04 Nov, 2014
Vitamin D improved brains in aging rats – Sept 2014 03 Oct, 2014
Vitamin D aids the aging skin – Sept 2012 21 Sep, 2014
Vitamin D levels vs age: compares references by IOM and Endocine Society – MENA study 2014 16 Aug, 2014
Understanding vitamin D deficiency - Editorial in Age and Ageing July 2014 02 Aug, 2014
Death rate 2X higher at age 60 if low vitamin D - 180,000 in Israel May 2012 13 Jun, 2014
Diabetes onset at age 76 was weakly associated with low vitamin D - June 2014 03 Jun, 2014
5X more likely to have facial skin aging if vitamin D insufficient – Dec 2010 26 Mar, 2014
5X less likely to have facial skin aging if vitamin D insufficient – Dec 2010 26 Mar, 2014
Higher vitamin D during pregnancy associated with stronger hand grip at age 4 – Oct 2013 03 Jan, 2014
Age-adjusted dementia may be declining – NEJM Dec 2013 01 Jan, 2014
Less bone mass at age 9 if low vitamin D during pregnancy and childhood – Lancet 2006 11 Nov, 2013
Low vitamin D during pregnancy resulted in 2.7 percent less bone content at age 20 – Nov 2013 11 Nov, 2013
Vitamin D test statistics: recent increase, esp. middle age, most under 30ng – Nov 2013 06 Nov, 2013
Just 700 IU of vitamin D during pregnancy reduced rate of asthma at age 7 by 26 percent – Oct 2013 05 Nov, 2013
Vitamin D deficiency in Rheumatology clinics in Iran (D increases with age)– May 2013 02 Nov, 2013
Huge variation in taking vitamin D supplements with age of female, less than 1000 IU not help much – July 2013 29 Aug, 2013
RXRA gene activity at birth weakly associated with bone density at age 4 – Aug 2013 15 Aug, 2013
Fastest bone growth occurs before age 2 24 Jun, 2013
How vitamin D protects the skin from the sun and from aging – Dec 2012 08 Mar, 2013
Vitamin D: Oxidative Stress, Immunity, and Aging – book Oct 2012 08 Dec, 2012
Vitamin D Omega 3 and Exercise are being used in controlled trial to support healthy ageing – Feb 2012 24 Nov, 2012
Knee osteoarthritis associated with low vitamin D for those under age 55 – Dec 2010 10 Nov, 2012
Low vitamin D in womb linked to more weight at age 6 – May 2012 24 May, 2012
Unspecified differences in vitamin D at age 10 failed to predict intelligence at age 15 – April 2012 13 Apr, 2012
Appears that some CNS ageing problems can be avoided with vitamin D – July 2010 06 Oct, 2011
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22+ VitaminDWiki pages have LONGEVITY etc in the title

This list is automatically updated

Items found: 26
Title Modified
Longevity and healthspan increased by Vitamin D, Omega-3, Magnesium - many studies 21 Jul, 2024
Yet another Longevity book includes a Vitamin D section (Longevity Leap) – Sept 2024 21 Jul, 2024
5% of the world consumes 55% of the prescription medications while lifespan is decreasing (US) – March 2024 19 Mar, 2024
Low Vitamin D is one reason for shorter lifespan amoung the poor - Dec 2023 22 Jan, 2024
High Omega-3 index increases longevity, even among smokers - Patrick Jan 2024 17 Jan, 2024
Extending Health Span is a better goal than extending Lifespan -July 2021 01 Jan, 2024
16 Longevity books compared in a video - Dec 2023 20 Dec, 2023
Possible large Vitamin D intervention trial to increase longevity in Saudi Arabia etc. 10 Dec, 2023
Life-extension, improved healthspan: Diet, Exercise, Omega-3, Vitamin D - many studies 09 Dec, 2023
The Longevity and Brain Benefits of Vigorous Exercise - Patrick video Dec 2023 05 Dec, 2023
The ONE Supplement All Longevity Experts Are Taking (Magnesium) - video and transcript Dec 2023 03 Dec, 2023
Longevity experts take Vitamin D, Omega-3, and Magnesium - Patrick video Sept 2023 10 Nov, 2023
How Vitamin D, Omega-3s, and Exercise May Increase Longevity - Patrick Nov 2023 10 Nov, 2023
Magnesium Role in Health and Longevity - many studies 18 Oct, 2022
Vitamin D might increase lifespan – clinical trial with 5,000 mice - June 2021 06 Jun, 2021
Longevity expert (Sinclair) supplements include Vitamin D, Vitamin K, and Resveratrol – Sept 2019 30 Sep, 2019
Lifespan and healthspan extension by resveratrol - Jan 2015 28 Apr, 2019
Healthspan is more important than Lifespan – JAMA Oct 2018 02 Oct, 2018
Centenarians have good Vitamin D Receptors (longevity is also increased by higher Vit D levels) – Aug 2016 24 Jul, 2017
Avoiding the sun reduces lifespan by 2 years (smoking reduces lifespan by 10 years) – March 2016 09 Jun, 2017
Sunbathing (vitamin D) increases lifespan in Sweden by about 1 year – March 2016 09 Jun, 2017
Vitamin D extends lifespan about 60 percent (for worms in a lab) – Oct 2016 26 Oct, 2016
Micronutrients, methylation, epigenetics, longevity podcast by Rhonda Patrick and Tim Ferriss - June 2015 22 Jun, 2015
Off topic: Special issue on Longevity in the Journal Nature - free text Dec 2012 07 Dec, 2012
If you have inherited longevity genes you can take 200 IU less vitamin D - Nov 2012 09 Nov, 2012
Every hour of TV watched reduces your lifespan by 22 minutes – Aug 2011 26 Aug, 2011
Vitamin K can reduce aging - April 2021        
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